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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-2379485-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=2379485&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "17",
      "pos": 2379485,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "ENST00000268989.8",
      "consequences": [
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3121G>A",
          "hgvs_p": "p.Val1041Ile",
          "transcript": "NM_014853.3",
          "protein_id": "NP_055668.2",
          "transcript_support_level": null,
          "aa_start": 1041,
          "aa_end": null,
          "aa_length": 1051,
          "cds_start": 3121,
          "cds_end": null,
          "cds_length": 3156,
          "cdna_start": 3309,
          "cdna_end": null,
          "cdna_length": 4878,
          "mane_select": "ENST00000268989.8",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3121G>A",
          "hgvs_p": "p.Val1041Ile",
          "transcript": "ENST00000268989.8",
          "protein_id": "ENSP00000268989.3",
          "transcript_support_level": 1,
          "aa_start": 1041,
          "aa_end": null,
          "aa_length": 1051,
          "cds_start": 3121,
          "cds_end": null,
          "cds_length": 3156,
          "cdna_start": 3309,
          "cdna_end": null,
          "cdna_length": 4878,
          "mane_select": "NM_014853.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.2986G>A",
          "hgvs_p": "p.Val996Ile",
          "transcript": "ENST00000426855.6",
          "protein_id": "ENSP00000415107.2",
          "transcript_support_level": 1,
          "aa_start": 996,
          "aa_end": null,
          "aa_length": 1006,
          "cds_start": 2986,
          "cds_end": null,
          "cds_length": 3021,
          "cdna_start": 3161,
          "cdna_end": null,
          "cdna_length": 4734,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.2986G>A",
          "hgvs_p": "p.Val996Ile",
          "transcript": "NM_001098509.2",
          "protein_id": "NP_001091979.1",
          "transcript_support_level": null,
          "aa_start": 996,
          "aa_end": null,
          "aa_length": 1006,
          "cds_start": 2986,
          "cds_end": null,
          "cds_length": 3021,
          "cdna_start": 3174,
          "cdna_end": null,
          "cdna_length": 4743,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.88G>A",
          "hgvs_p": "p.Val30Ile",
          "transcript": "ENST00000572925.1",
          "protein_id": "ENSP00000461820.2",
          "transcript_support_level": 3,
          "aa_start": 30,
          "aa_end": null,
          "aa_length": 35,
          "cds_start": 88,
          "cds_end": null,
          "cds_length": 108,
          "cdna_start": 90,
          "cdna_end": null,
          "cdna_length": 644,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 25,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3259G>A",
          "hgvs_p": "p.Val1087Ile",
          "transcript": "XM_011524102.4",
          "protein_id": "XP_011522404.1",
          "transcript_support_level": null,
          "aa_start": 1087,
          "aa_end": null,
          "aa_length": 1097,
          "cds_start": 3259,
          "cds_end": null,
          "cds_length": 3294,
          "cdna_start": 3447,
          "cdna_end": null,
          "cdna_length": 5016,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 25,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3259G>A",
          "hgvs_p": "p.Val1087Ile",
          "transcript": "XM_011524103.4",
          "protein_id": "XP_011522405.1",
          "transcript_support_level": null,
          "aa_start": 1087,
          "aa_end": null,
          "aa_length": 1092,
          "cds_start": 3259,
          "cds_end": null,
          "cds_length": 3279,
          "cdna_start": 3447,
          "cdna_end": null,
          "cdna_length": 4245,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3124G>A",
          "hgvs_p": "p.Val1042Ile",
          "transcript": "XM_017025474.3",
          "protein_id": "XP_016880963.1",
          "transcript_support_level": null,
          "aa_start": 1042,
          "aa_end": null,
          "aa_length": 1052,
          "cds_start": 3124,
          "cds_end": null,
          "cds_length": 3159,
          "cdna_start": 3312,
          "cdna_end": null,
          "cdna_length": 4881,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3124G>A",
          "hgvs_p": "p.Val1042Ile",
          "transcript": "XM_017025475.3",
          "protein_id": "XP_016880964.1",
          "transcript_support_level": null,
          "aa_start": 1042,
          "aa_end": null,
          "aa_length": 1047,
          "cds_start": 3124,
          "cds_end": null,
          "cds_length": 3144,
          "cdna_start": 3312,
          "cdna_end": null,
          "cdna_length": 4110,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3076G>A",
          "hgvs_p": "p.Val1026Ile",
          "transcript": "XM_047437209.1",
          "protein_id": "XP_047293165.1",
          "transcript_support_level": null,
          "aa_start": 1026,
          "aa_end": null,
          "aa_length": 1036,
          "cds_start": 3076,
          "cds_end": null,
          "cds_length": 3111,
          "cdna_start": 3264,
          "cdna_end": null,
          "cdna_length": 4833,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.2986G>A",
          "hgvs_p": "p.Val996Ile",
          "transcript": "XM_047437210.1",
          "protein_id": "XP_047293166.1",
          "transcript_support_level": null,
          "aa_start": 996,
          "aa_end": null,
          "aa_length": 1001,
          "cds_start": 2986,
          "cds_end": null,
          "cds_length": 3006,
          "cdna_start": 3174,
          "cdna_end": null,
          "cdna_length": 3972,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.2941G>A",
          "hgvs_p": "p.Val981Ile",
          "transcript": "XM_047437212.1",
          "protein_id": "XP_047293168.1",
          "transcript_support_level": null,
          "aa_start": 981,
          "aa_end": null,
          "aa_length": 991,
          "cds_start": 2941,
          "cds_end": null,
          "cds_length": 2976,
          "cdna_start": 3129,
          "cdna_end": null,
          "cdna_length": 4698,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.2938G>A",
          "hgvs_p": "p.Val980Ile",
          "transcript": "XM_047437213.1",
          "protein_id": "XP_047293169.1",
          "transcript_support_level": null,
          "aa_start": 980,
          "aa_end": null,
          "aa_length": 990,
          "cds_start": 2938,
          "cds_end": null,
          "cds_length": 2973,
          "cdna_start": 3126,
          "cdna_end": null,
          "cdna_length": 4695,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 25,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3279G>A",
          "hgvs_p": "p.Ser1093Ser",
          "transcript": "XM_011524101.4",
          "protein_id": "XP_011522403.1",
          "transcript_support_level": null,
          "aa_start": 1093,
          "aa_end": null,
          "aa_length": 1103,
          "cds_start": 3279,
          "cds_end": null,
          "cds_length": 3312,
          "cdna_start": 3467,
          "cdna_end": null,
          "cdna_length": 4265,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 25,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3231G>A",
          "hgvs_p": "p.Ser1077Ser",
          "transcript": "XM_011524104.3",
          "protein_id": "XP_011522406.1",
          "transcript_support_level": null,
          "aa_start": 1077,
          "aa_end": null,
          "aa_length": 1087,
          "cds_start": 3231,
          "cds_end": null,
          "cds_length": 3264,
          "cdna_start": 4907,
          "cdna_end": null,
          "cdna_length": 5705,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3144G>A",
          "hgvs_p": "p.Ser1048Ser",
          "transcript": "XM_011524105.4",
          "protein_id": "XP_011522407.1",
          "transcript_support_level": null,
          "aa_start": 1048,
          "aa_end": null,
          "aa_length": 1058,
          "cds_start": 3144,
          "cds_end": null,
          "cds_length": 3177,
          "cdna_start": 3332,
          "cdna_end": null,
          "cdna_length": 4130,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3141G>A",
          "hgvs_p": "p.Ser1047Ser",
          "transcript": "XM_011524106.2",
          "protein_id": "XP_011522408.1",
          "transcript_support_level": null,
          "aa_start": 1047,
          "aa_end": null,
          "aa_length": 1057,
          "cds_start": 3141,
          "cds_end": null,
          "cds_length": 3174,
          "cdna_start": 3329,
          "cdna_end": null,
          "cdna_length": 4127,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 24,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3096G>A",
          "hgvs_p": "p.Ser1032Ser",
          "transcript": "XM_011524107.4",
          "protein_id": "XP_011522409.1",
          "transcript_support_level": null,
          "aa_start": 1032,
          "aa_end": null,
          "aa_length": 1042,
          "cds_start": 3096,
          "cds_end": null,
          "cds_length": 3129,
          "cdna_start": 3284,
          "cdna_end": null,
          "cdna_length": 4082,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.3006G>A",
          "hgvs_p": "p.Ser1002Ser",
          "transcript": "XM_011524108.2",
          "protein_id": "XP_011522410.1",
          "transcript_support_level": null,
          "aa_start": 1002,
          "aa_end": null,
          "aa_length": 1012,
          "cds_start": 3006,
          "cds_end": null,
          "cds_length": 3039,
          "cdna_start": 3194,
          "cdna_end": null,
          "cdna_length": 3992,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SGSM2",
          "gene_hgnc_id": 29026,
          "hgvs_c": "c.2961G>A",
          "hgvs_p": "p.Ser987Ser",
          "transcript": "XM_047437211.1",
          "protein_id": "XP_047293167.1",
          "transcript_support_level": null,
          "aa_start": 987,
          "aa_end": null,
          "aa_length": 997,
          "cds_start": 2961,
          "cds_end": null,
          "cds_length": 2994,
          "cdna_start": 3149,
          "cdna_end": null,
          "cdna_length": 3947,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
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        {
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      ],
      "gene_symbol": "SGSM2",
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      "dbsnp": "rs61741902",
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      "allele_count_reference_population": 19170,
      "gnomad_exomes_af": 0.0121798,
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      "gnomad_exomes_homalt": 118,
      "gnomad_genomes_homalt": 9,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.007389634847640991,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.05000000074505806,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.276,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.1243,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.5,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 8.117,
      "phylop100way_prediction": "Pathogenic",
      "spliceai_max_score": 0.05,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
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      "acmg_score": -8,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BS2",
      "acmg_by_gene": [
        {
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          "benign_score": 8,
          "pathogenic_score": 0,
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            "BS2"
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          "verdict": "Benign",
          "transcript": "ENST00000268989.8",
          "gene_symbol": "SGSM2",
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          "effects": [
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        {
          "score": -8,
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            "BS2"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000574290.1",
          "gene_symbol": "SGSM2-AS1",
          "hgnc_id": 56091,
          "effects": [
            "upstream_gene_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.-179C>T",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}