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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-3591067-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=3591067&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 3591067,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000572705.2",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "NM_080704.4",
"protein_id": "NP_542435.2",
"transcript_support_level": null,
"aa_start": 167,
"aa_end": null,
"aa_length": 839,
"cds_start": 501,
"cds_end": null,
"cds_length": 2520,
"cdna_start": 776,
"cdna_end": null,
"cdna_length": 4164,
"mane_select": "ENST00000572705.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "ENST00000572705.2",
"protein_id": "ENSP00000459962.1",
"transcript_support_level": 1,
"aa_start": 167,
"aa_end": null,
"aa_length": 839,
"cds_start": 501,
"cds_end": null,
"cds_length": 2520,
"cdna_start": 776,
"cdna_end": null,
"cdna_length": 4164,
"mane_select": "NM_080704.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "ENST00000425167.6",
"protein_id": "ENSP00000409627.2",
"transcript_support_level": 1,
"aa_start": 167,
"aa_end": null,
"aa_length": 850,
"cds_start": 501,
"cds_end": null,
"cds_length": 2553,
"cdna_start": 518,
"cdna_end": null,
"cdna_length": 2607,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "ENST00000399756.8",
"protein_id": "ENSP00000382659.4",
"transcript_support_level": 1,
"aa_start": 167,
"aa_end": null,
"aa_length": 839,
"cds_start": 501,
"cds_end": null,
"cds_length": 2520,
"cdna_start": 1028,
"cdna_end": null,
"cdna_length": 4068,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "ENST00000399759.7",
"protein_id": "ENSP00000382661.3",
"transcript_support_level": 1,
"aa_start": 167,
"aa_end": null,
"aa_length": 839,
"cds_start": 501,
"cds_end": null,
"cds_length": 2520,
"cdna_start": 702,
"cdna_end": null,
"cdna_length": 4092,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "ENST00000571088.5",
"protein_id": "ENSP00000461007.1",
"transcript_support_level": 1,
"aa_start": 167,
"aa_end": null,
"aa_length": 839,
"cds_start": 501,
"cds_end": null,
"cds_length": 2520,
"cdna_start": 715,
"cdna_end": null,
"cdna_length": 4105,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "ENST00000310522.5",
"protein_id": "ENSP00000311692.5",
"transcript_support_level": 1,
"aa_start": 167,
"aa_end": null,
"aa_length": 779,
"cds_start": 501,
"cds_end": null,
"cds_length": 2340,
"cdna_start": 501,
"cdna_end": null,
"cdna_length": 2340,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000262304",
"gene_hgnc_id": null,
"hgvs_c": "n.*1785C>A",
"hgvs_p": null,
"transcript": "ENST00000572919.1",
"protein_id": "ENSP00000461416.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4753,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000262304",
"gene_hgnc_id": null,
"hgvs_c": "n.*1785C>A",
"hgvs_p": null,
"transcript": "ENST00000572919.1",
"protein_id": "ENSP00000461416.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4753,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "NM_018727.5",
"protein_id": "NP_061197.4",
"transcript_support_level": null,
"aa_start": 167,
"aa_end": null,
"aa_length": 839,
"cds_start": 501,
"cds_end": null,
"cds_length": 2520,
"cdna_start": 659,
"cdna_end": null,
"cdna_length": 4047,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "NM_080705.4",
"protein_id": "NP_542436.2",
"transcript_support_level": null,
"aa_start": 167,
"aa_end": null,
"aa_length": 839,
"cds_start": 501,
"cds_end": null,
"cds_length": 2520,
"cdna_start": 702,
"cdna_end": null,
"cdna_length": 4090,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "NM_080706.3",
"protein_id": "NP_542437.2",
"transcript_support_level": null,
"aa_start": 167,
"aa_end": null,
"aa_length": 839,
"cds_start": 501,
"cds_end": null,
"cds_length": 2520,
"cdna_start": 1028,
"cdna_end": null,
"cdna_length": 4416,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln",
"transcript": "ENST00000576351.5",
"protein_id": "ENSP00000459042.1",
"transcript_support_level": 5,
"aa_start": 167,
"aa_end": null,
"aa_length": 829,
"cds_start": 501,
"cds_end": null,
"cds_length": 2490,
"cdna_start": 534,
"cdna_end": null,
"cdna_length": 2525,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "n.588C>A",
"hgvs_p": null,
"transcript": "ENST00000574085.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2644,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"hgvs_c": "n.501C>A",
"hgvs_p": null,
"transcript": "ENST00000650505.1",
"protein_id": "ENSP00000497337.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4732,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
}
],
"gene_symbol": "TRPV1",
"gene_hgnc_id": 12716,
"dbsnp": "rs222748",
"frequency_reference_population": 0.000010540674,
"hom_count_reference_population": 0,
"allele_count_reference_population": 17,
"gnomad_exomes_af": 0.000004108,
"gnomad_genomes_af": 0.0000722562,
"gnomad_exomes_ac": 6,
"gnomad_genomes_ac": 11,
"gnomad_exomes_homalt": 0,
"gnomad_genomes_homalt": 0,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": 0.03066962957382202,
"computational_prediction_selected": "Benign",
"computational_source_selected": "MetaRNN",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": 0.326,
"revel_prediction": "Uncertain_significance",
"alphamissense_score": 0.1393,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.35,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": -0.727,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": -8,
"acmg_classification": "Benign",
"acmg_criteria": "BP4_Strong,BS2",
"acmg_by_gene": [
{
"score": -8,
"benign_score": 8,
"pathogenic_score": 0,
"criteria": [
"BP4_Strong",
"BS2"
],
"verdict": "Benign",
"transcript": "ENST00000572705.2",
"gene_symbol": "TRPV1",
"hgnc_id": 12716,
"effects": [
"missense_variant"
],
"inheritance_mode": "AD",
"hgvs_c": "c.501C>A",
"hgvs_p": "p.His167Gln"
},
{
"score": -4,
"benign_score": 4,
"pathogenic_score": 0,
"criteria": [
"BP4_Strong"
],
"verdict": "Likely_benign",
"transcript": "ENST00000572919.1",
"gene_symbol": "ENSG00000262304",
"hgnc_id": null,
"effects": [
"non_coding_transcript_exon_variant"
],
"inheritance_mode": "",
"hgvs_c": "n.*1785C>A",
"hgvs_p": null
}
],
"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}