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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-37536006-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=37536006&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 37536006,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_001405103.1",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3639C>T",
"hgvs_p": "p.Ile1213Ile",
"transcript": "NM_007247.6",
"protein_id": "NP_009178.3",
"transcript_support_level": null,
"aa_start": 1213,
"aa_end": null,
"aa_length": 1314,
"cds_start": 3639,
"cds_end": null,
"cds_length": 3945,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000612223.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007247.6"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3639C>T",
"hgvs_p": "p.Ile1213Ile",
"transcript": "ENST00000612223.5",
"protein_id": "ENSP00000483453.1",
"transcript_support_level": 1,
"aa_start": 1213,
"aa_end": null,
"aa_length": 1314,
"cds_start": 3639,
"cds_end": null,
"cds_length": 3945,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_007247.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000612223.5"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3405C>T",
"hgvs_p": "p.Ile1135Ile",
"transcript": "ENST00000622045.4",
"protein_id": "ENSP00000483063.1",
"transcript_support_level": 1,
"aa_start": 1135,
"aa_end": null,
"aa_length": 1259,
"cds_start": 3405,
"cds_end": null,
"cds_length": 3780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000622045.4"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3402C>T",
"hgvs_p": "p.Ile1134Ile",
"transcript": "ENST00000619541.4",
"protein_id": "ENSP00000477885.1",
"transcript_support_level": 1,
"aa_start": 1134,
"aa_end": null,
"aa_length": 1235,
"cds_start": 3402,
"cds_end": null,
"cds_length": 3708,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000619541.4"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3405C>T",
"hgvs_p": "p.Ile1135Ile",
"transcript": "ENST00000621136.4",
"protein_id": "ENSP00000484529.1",
"transcript_support_level": 1,
"aa_start": 1135,
"aa_end": null,
"aa_length": 1224,
"cds_start": 3405,
"cds_end": null,
"cds_length": 3675,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000621136.4"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3021C>T",
"hgvs_p": "p.Ile1007Ile",
"transcript": "ENST00000614941.4",
"protein_id": "ENSP00000481151.1",
"transcript_support_level": 1,
"aa_start": 1007,
"aa_end": null,
"aa_length": 1108,
"cds_start": 3021,
"cds_end": null,
"cds_length": 3327,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000614941.4"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3942C>T",
"hgvs_p": "p.Ile1314Ile",
"transcript": "NM_001405103.1",
"protein_id": "NP_001392032.1",
"transcript_support_level": null,
"aa_start": 1314,
"aa_end": null,
"aa_length": 1438,
"cds_start": 3942,
"cds_end": null,
"cds_length": 4317,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001405103.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3942C>T",
"hgvs_p": "p.Ile1314Ile",
"transcript": "ENST00000864300.1",
"protein_id": "ENSP00000534359.1",
"transcript_support_level": null,
"aa_start": 1314,
"aa_end": null,
"aa_length": 1415,
"cds_start": 3942,
"cds_end": null,
"cds_length": 4248,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864300.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3939C>T",
"hgvs_p": "p.Ile1313Ile",
"transcript": "ENST00000864302.1",
"protein_id": "ENSP00000534361.1",
"transcript_support_level": null,
"aa_start": 1313,
"aa_end": null,
"aa_length": 1414,
"cds_start": 3939,
"cds_end": null,
"cds_length": 4245,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864302.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3942C>T",
"hgvs_p": "p.Ile1314Ile",
"transcript": "ENST00000936287.1",
"protein_id": "ENSP00000606346.1",
"transcript_support_level": null,
"aa_start": 1314,
"aa_end": null,
"aa_length": 1403,
"cds_start": 3942,
"cds_end": null,
"cds_length": 4212,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936287.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3939C>T",
"hgvs_p": "p.Ile1313Ile",
"transcript": "ENST00000936288.1",
"protein_id": "ENSP00000606347.1",
"transcript_support_level": null,
"aa_start": 1313,
"aa_end": null,
"aa_length": 1402,
"cds_start": 3939,
"cds_end": null,
"cds_length": 4209,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936288.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3807C>T",
"hgvs_p": "p.Ile1269Ile",
"transcript": "ENST00000864291.1",
"protein_id": "ENSP00000534350.1",
"transcript_support_level": null,
"aa_start": 1269,
"aa_end": null,
"aa_length": 1370,
"cds_start": 3807,
"cds_end": null,
"cds_length": 4113,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864291.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3804C>T",
"hgvs_p": "p.Ile1268Ile",
"transcript": "ENST00000864304.1",
"protein_id": "ENSP00000534363.1",
"transcript_support_level": null,
"aa_start": 1268,
"aa_end": null,
"aa_length": 1369,
"cds_start": 3804,
"cds_end": null,
"cds_length": 4110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864304.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3804C>T",
"hgvs_p": "p.Ile1268Ile",
"transcript": "ENST00000972435.1",
"protein_id": "ENSP00000642494.1",
"transcript_support_level": null,
"aa_start": 1268,
"aa_end": null,
"aa_length": 1369,
"cds_start": 3804,
"cds_end": null,
"cds_length": 4110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000972435.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3801C>T",
"hgvs_p": "p.Ile1267Ile",
"transcript": "ENST00000936284.1",
"protein_id": "ENSP00000606343.1",
"transcript_support_level": null,
"aa_start": 1267,
"aa_end": null,
"aa_length": 1368,
"cds_start": 3801,
"cds_end": null,
"cds_length": 4107,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936284.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3807C>T",
"hgvs_p": "p.Ile1269Ile",
"transcript": "ENST00000864303.1",
"protein_id": "ENSP00000534362.1",
"transcript_support_level": null,
"aa_start": 1269,
"aa_end": null,
"aa_length": 1358,
"cds_start": 3807,
"cds_end": null,
"cds_length": 4077,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864303.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3804C>T",
"hgvs_p": "p.Ile1268Ile",
"transcript": "ENST00000936286.1",
"protein_id": "ENSP00000606345.1",
"transcript_support_level": null,
"aa_start": 1268,
"aa_end": null,
"aa_length": 1357,
"cds_start": 3804,
"cds_end": null,
"cds_length": 4074,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936286.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3801C>T",
"hgvs_p": "p.Ile1267Ile",
"transcript": "ENST00000864296.1",
"protein_id": "ENSP00000534355.1",
"transcript_support_level": null,
"aa_start": 1267,
"aa_end": null,
"aa_length": 1356,
"cds_start": 3801,
"cds_end": null,
"cds_length": 4071,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864296.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3687C>T",
"hgvs_p": "p.Ile1229Ile",
"transcript": "ENST00000972438.1",
"protein_id": "ENSP00000642497.1",
"transcript_support_level": null,
"aa_start": 1229,
"aa_end": null,
"aa_length": 1330,
"cds_start": 3687,
"cds_end": null,
"cds_length": 3993,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000972438.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3639C>T",
"hgvs_p": "p.Ile1213Ile",
"transcript": "ENST00000864308.1",
"protein_id": "ENSP00000534367.1",
"transcript_support_level": null,
"aa_start": 1213,
"aa_end": null,
"aa_length": 1325,
"cds_start": 3639,
"cds_end": null,
"cds_length": 3978,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000864308.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3636C>T",
"hgvs_p": "p.Ile1212Ile",
"transcript": "ENST00000936285.1",
"protein_id": "ENSP00000606344.1",
"transcript_support_level": null,
"aa_start": 1212,
"aa_end": null,
"aa_length": 1313,
"cds_start": 3636,
"cds_end": null,
"cds_length": 3942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936285.1"
},
{
"aa_ref": "I",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.3642C>T",
"hgvs_p": "p.Ile1214Ile",
"transcript": "ENST00000864301.1",
"protein_id": "ENSP00000534360.1",
"transcript_support_level": null,
"aa_start": 1214,
"aa_end": null,
"aa_length": 1303,
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"bayesdelnoaf_score": -0.75,
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"phylop100way_prediction": "Benign",
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{
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"BP4_Strong",
"BP6",
"BP7"
],
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],
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"clinvar_review_status": "no assertion criteria provided",
"clinvar_submissions_summary": "null",
"phenotype_combined": "SYNRG-related disorder",
"pathogenicity_classification_combined": "Likely benign",
"custom_annotations": null
}
],
"message": null
}