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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-37561200-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=37561200&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 37561200,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000612223.5",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1658C>A",
"hgvs_p": "p.Pro553His",
"transcript": "NM_007247.6",
"protein_id": "NP_009178.3",
"transcript_support_level": null,
"aa_start": 553,
"aa_end": null,
"aa_length": 1314,
"cds_start": 1658,
"cds_end": null,
"cds_length": 3945,
"cdna_start": 1721,
"cdna_end": null,
"cdna_length": 8141,
"mane_select": "ENST00000612223.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1658C>A",
"hgvs_p": "p.Pro553His",
"transcript": "ENST00000612223.5",
"protein_id": "ENSP00000483453.1",
"transcript_support_level": 1,
"aa_start": 553,
"aa_end": null,
"aa_length": 1314,
"cds_start": 1658,
"cds_end": null,
"cds_length": 3945,
"cdna_start": 1721,
"cdna_end": null,
"cdna_length": 8141,
"mane_select": "NM_007247.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1424C>A",
"hgvs_p": "p.Pro475His",
"transcript": "ENST00000622045.4",
"protein_id": "ENSP00000483063.1",
"transcript_support_level": 1,
"aa_start": 475,
"aa_end": null,
"aa_length": 1259,
"cds_start": 1424,
"cds_end": null,
"cds_length": 3780,
"cdna_start": 1450,
"cdna_end": null,
"cdna_length": 3859,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1421C>A",
"hgvs_p": "p.Pro474His",
"transcript": "ENST00000619541.4",
"protein_id": "ENSP00000477885.1",
"transcript_support_level": 1,
"aa_start": 474,
"aa_end": null,
"aa_length": 1235,
"cds_start": 1421,
"cds_end": null,
"cds_length": 3708,
"cdna_start": 1447,
"cdna_end": null,
"cdna_length": 3787,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1424C>A",
"hgvs_p": "p.Pro475His",
"transcript": "ENST00000621136.4",
"protein_id": "ENSP00000484529.1",
"transcript_support_level": 1,
"aa_start": 475,
"aa_end": null,
"aa_length": 1224,
"cds_start": 1424,
"cds_end": null,
"cds_length": 3675,
"cdna_start": 1480,
"cdna_end": null,
"cdna_length": 4841,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1175C>A",
"hgvs_p": "p.Pro392His",
"transcript": "ENST00000614941.4",
"protein_id": "ENSP00000481151.1",
"transcript_support_level": 1,
"aa_start": 392,
"aa_end": null,
"aa_length": 1108,
"cds_start": 1175,
"cds_end": null,
"cds_length": 3327,
"cdna_start": 1201,
"cdna_end": null,
"cdna_length": 3406,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "n.1120C>A",
"hgvs_p": null,
"transcript": "ENST00000611910.4",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1769,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1961C>A",
"hgvs_p": "p.Pro654His",
"transcript": "NM_001405103.1",
"protein_id": "NP_001392032.1",
"transcript_support_level": null,
"aa_start": 654,
"aa_end": null,
"aa_length": 1438,
"cds_start": 1961,
"cds_end": null,
"cds_length": 4317,
"cdna_start": 2024,
"cdna_end": null,
"cdna_length": 8513,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1424C>A",
"hgvs_p": "p.Pro475His",
"transcript": "NM_198882.3",
"protein_id": "NP_942583.1",
"transcript_support_level": null,
"aa_start": 475,
"aa_end": null,
"aa_length": 1259,
"cds_start": 1424,
"cds_end": null,
"cds_length": 3780,
"cdna_start": 1487,
"cdna_end": null,
"cdna_length": 7976,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1424C>A",
"hgvs_p": "p.Pro475His",
"transcript": "NM_001163544.3",
"protein_id": "NP_001157016.1",
"transcript_support_level": null,
"aa_start": 475,
"aa_end": null,
"aa_length": 1236,
"cds_start": 1424,
"cds_end": null,
"cds_length": 3711,
"cdna_start": 1487,
"cdna_end": null,
"cdna_length": 7907,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1421C>A",
"hgvs_p": "p.Pro474His",
"transcript": "NM_001163545.3",
"protein_id": "NP_001157017.1",
"transcript_support_level": null,
"aa_start": 474,
"aa_end": null,
"aa_length": 1235,
"cds_start": 1421,
"cds_end": null,
"cds_length": 3708,
"cdna_start": 1484,
"cdna_end": null,
"cdna_length": 7904,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1424C>A",
"hgvs_p": "p.Pro475His",
"transcript": "NM_080550.5",
"protein_id": "NP_542117.3",
"transcript_support_level": null,
"aa_start": 475,
"aa_end": null,
"aa_length": 1224,
"cds_start": 1424,
"cds_end": null,
"cds_length": 3675,
"cdna_start": 1487,
"cdna_end": null,
"cdna_length": 7871,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1424C>A",
"hgvs_p": "p.Pro475His",
"transcript": "NM_001163546.3",
"protein_id": "NP_001157018.1",
"transcript_support_level": null,
"aa_start": 475,
"aa_end": null,
"aa_length": 1179,
"cds_start": 1424,
"cds_end": null,
"cds_length": 3540,
"cdna_start": 1487,
"cdna_end": null,
"cdna_length": 7736,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1424C>A",
"hgvs_p": "p.Pro475His",
"transcript": "ENST00000616179.4",
"protein_id": "ENSP00000482962.1",
"transcript_support_level": 5,
"aa_start": 475,
"aa_end": null,
"aa_length": 1179,
"cds_start": 1424,
"cds_end": null,
"cds_length": 3540,
"cdna_start": 1455,
"cdna_end": null,
"cdna_length": 4050,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1175C>A",
"hgvs_p": "p.Pro392His",
"transcript": "NM_001163547.3",
"protein_id": "NP_001157019.1",
"transcript_support_level": null,
"aa_start": 392,
"aa_end": null,
"aa_length": 1108,
"cds_start": 1175,
"cds_end": null,
"cds_length": 3327,
"cdna_start": 1238,
"cdna_end": null,
"cdna_length": 7523,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1958C>A",
"hgvs_p": "p.Pro653His",
"transcript": "XM_017024077.1",
"protein_id": "XP_016879566.1",
"transcript_support_level": null,
"aa_start": 653,
"aa_end": null,
"aa_length": 1437,
"cds_start": 1958,
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"cdna_start": 2021,
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"cdna_length": 8510,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1961C>A",
"hgvs_p": "p.Pro654His",
"transcript": "XM_005256980.6",
"protein_id": "XP_005257037.1",
"transcript_support_level": null,
"aa_start": 654,
"aa_end": null,
"aa_length": 1415,
"cds_start": 1961,
"cds_end": null,
"cds_length": 4248,
"cdna_start": 2024,
"cdna_end": null,
"cdna_length": 8444,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1958C>A",
"hgvs_p": "p.Pro653His",
"transcript": "XM_047435225.1",
"protein_id": "XP_047291181.1",
"transcript_support_level": null,
"aa_start": 653,
"aa_end": null,
"aa_length": 1414,
"cds_start": 1958,
"cds_end": null,
"cds_length": 4245,
"cdna_start": 2021,
"cdna_end": null,
"cdna_length": 8441,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1880C>A",
"hgvs_p": "p.Pro627His",
"transcript": "XM_047435226.1",
"protein_id": "XP_047291182.1",
"transcript_support_level": null,
"aa_start": 627,
"aa_end": null,
"aa_length": 1411,
"cds_start": 1880,
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"cdna_start": 1935,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1877C>A",
"hgvs_p": "p.Pro626His",
"transcript": "XM_017024081.3",
"protein_id": "XP_016879570.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 1410,
"cds_start": 1877,
"cds_end": null,
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"cdna_start": 1932,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1961C>A",
"hgvs_p": "p.Pro654His",
"transcript": "XM_017024082.2",
"protein_id": "XP_016879571.1",
"transcript_support_level": null,
"aa_start": 654,
"aa_end": null,
"aa_length": 1403,
"cds_start": 1961,
"cds_end": null,
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"cdna_start": 2024,
"cdna_end": null,
"cdna_length": 8408,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1958C>A",
"hgvs_p": "p.Pro653His",
"transcript": "XM_047435227.1",
"protein_id": "XP_047291183.1",
"transcript_support_level": null,
"aa_start": 653,
"aa_end": null,
"aa_length": 1402,
"cds_start": 1958,
"cds_end": null,
"cds_length": 4209,
"cdna_start": 2021,
"cdna_end": null,
"cdna_length": 8405,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYNRG",
"gene_hgnc_id": 557,
"hgvs_c": "c.1961C>A",
"hgvs_p": "p.Pro654His",
"transcript": "XM_047435228.1",
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}