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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-39766006-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=39766006&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 39766006,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000346872.8",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1314C>T",
"hgvs_p": "p.Ser438Ser",
"transcript": "NM_012481.5",
"protein_id": "NP_036613.2",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 509,
"cds_start": 1314,
"cds_end": null,
"cds_length": 1530,
"cdna_start": 1500,
"cdna_end": null,
"cdna_length": 9788,
"mane_select": "ENST00000346872.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1314C>T",
"hgvs_p": "p.Ser438Ser",
"transcript": "ENST00000346872.8",
"protein_id": "ENSP00000344544.3",
"transcript_support_level": 1,
"aa_start": 438,
"aa_end": null,
"aa_length": 509,
"cds_start": 1314,
"cds_end": null,
"cds_length": 1530,
"cdna_start": 1500,
"cdna_end": null,
"cdna_length": 9788,
"mane_select": "NM_012481.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1212C>T",
"hgvs_p": "p.Ser404Ser",
"transcript": "ENST00000535189.5",
"protein_id": "ENSP00000438972.1",
"transcript_support_level": 1,
"aa_start": 404,
"aa_end": null,
"aa_length": 475,
"cds_start": 1212,
"cds_end": null,
"cds_length": 1428,
"cdna_start": 1274,
"cdna_end": null,
"cdna_length": 1996,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1095C>T",
"hgvs_p": "p.Ser365Ser",
"transcript": "ENST00000439167.6",
"protein_id": "ENSP00000403776.2",
"transcript_support_level": 1,
"aa_start": 365,
"aa_end": null,
"aa_length": 436,
"cds_start": 1095,
"cds_end": null,
"cds_length": 1311,
"cdna_start": 1157,
"cdna_end": null,
"cdna_length": 1879,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1053C>T",
"hgvs_p": "p.Ser351Ser",
"transcript": "ENST00000377958.7",
"protein_id": "ENSP00000367194.2",
"transcript_support_level": 1,
"aa_start": 351,
"aa_end": null,
"aa_length": 422,
"cds_start": 1053,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 1115,
"cdna_end": null,
"cdna_length": 9406,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.912C>T",
"hgvs_p": "p.Ser304Ser",
"transcript": "ENST00000377945.7",
"protein_id": "ENSP00000367180.3",
"transcript_support_level": 1,
"aa_start": 304,
"aa_end": null,
"aa_length": 375,
"cds_start": 912,
"cds_end": null,
"cds_length": 1128,
"cdna_start": 974,
"cdna_end": null,
"cdna_length": 1696,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.885C>T",
"hgvs_p": "p.Ser295Ser",
"transcript": "ENST00000377944.7",
"protein_id": "ENSP00000367179.3",
"transcript_support_level": 1,
"aa_start": 295,
"aa_end": null,
"aa_length": 366,
"cds_start": 885,
"cds_end": null,
"cds_length": 1101,
"cdna_start": 947,
"cdna_end": null,
"cdna_length": 1669,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.768C>T",
"hgvs_p": "p.Ser256Ser",
"transcript": "ENST00000394189.6",
"protein_id": "ENSP00000377741.2",
"transcript_support_level": 1,
"aa_start": 256,
"aa_end": null,
"aa_length": 327,
"cds_start": 768,
"cds_end": null,
"cds_length": 984,
"cdna_start": 830,
"cdna_end": null,
"cdna_length": 1552,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.651C>T",
"hgvs_p": "p.Ser217Ser",
"transcript": "ENST00000377952.6",
"protein_id": "ENSP00000367188.2",
"transcript_support_level": 1,
"aa_start": 217,
"aa_end": null,
"aa_length": 288,
"cds_start": 651,
"cds_end": null,
"cds_length": 867,
"cdna_start": 713,
"cdna_end": null,
"cdna_length": 1435,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.573C>T",
"hgvs_p": "p.Ser191Ser",
"transcript": "ENST00000623724.3",
"protein_id": "ENSP00000485515.1",
"transcript_support_level": 1,
"aa_start": 191,
"aa_end": null,
"aa_length": 262,
"cds_start": 573,
"cds_end": null,
"cds_length": 789,
"cdna_start": 1502,
"cdna_end": null,
"cdna_length": 9787,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "n.*648C>T",
"hgvs_p": null,
"transcript": "ENST00000293068.9",
"protein_id": "ENSP00000462791.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2224,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "n.*648C>T",
"hgvs_p": null,
"transcript": "ENST00000348427.7",
"protein_id": "ENSP00000463505.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2056,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "n.*648C>T",
"hgvs_p": null,
"transcript": "ENST00000293068.9",
"protein_id": "ENSP00000462791.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2224,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "n.*648C>T",
"hgvs_p": null,
"transcript": "ENST00000348427.7",
"protein_id": "ENSP00000463505.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2056,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1212C>T",
"hgvs_p": "p.Ser404Ser",
"transcript": "NM_001257408.2",
"protein_id": "NP_001244337.1",
"transcript_support_level": null,
"aa_start": 404,
"aa_end": null,
"aa_length": 475,
"cds_start": 1212,
"cds_end": null,
"cds_length": 1428,
"cdna_start": 1398,
"cdna_end": null,
"cdna_length": 9686,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1197C>T",
"hgvs_p": "p.Ser399Ser",
"transcript": "NM_183229.3",
"protein_id": "NP_899052.1",
"transcript_support_level": null,
"aa_start": 399,
"aa_end": null,
"aa_length": 470,
"cds_start": 1197,
"cds_end": null,
"cds_length": 1413,
"cdna_start": 1383,
"cdna_end": null,
"cdna_length": 9671,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1197C>T",
"hgvs_p": "p.Ser399Ser",
"transcript": "NM_183230.3",
"protein_id": "NP_899053.1",
"transcript_support_level": null,
"aa_start": 399,
"aa_end": null,
"aa_length": 470,
"cds_start": 1197,
"cds_end": null,
"cds_length": 1413,
"cdna_start": 1383,
"cdna_end": null,
"cdna_length": 9671,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1197C>T",
"hgvs_p": "p.Ser399Ser",
"transcript": "ENST00000350532.7",
"protein_id": "ENSP00000344471.3",
"transcript_support_level": 5,
"aa_start": 399,
"aa_end": null,
"aa_length": 470,
"cds_start": 1197,
"cds_end": null,
"cds_length": 1413,
"cdna_start": 1197,
"cdna_end": null,
"cdna_length": 1413,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1197C>T",
"hgvs_p": "p.Ser399Ser",
"transcript": "ENST00000351680.7",
"protein_id": "ENSP00000345622.3",
"transcript_support_level": 5,
"aa_start": 399,
"aa_end": null,
"aa_length": 470,
"cds_start": 1197,
"cds_end": null,
"cds_length": 1413,
"cdna_start": 1197,
"cdna_end": null,
"cdna_length": 1413,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1146C>T",
"hgvs_p": "p.Ser382Ser",
"transcript": "NM_183228.3",
"protein_id": "NP_899051.1",
"transcript_support_level": null,
"aa_start": 382,
"aa_end": null,
"aa_length": 453,
"cds_start": 1146,
"cds_end": null,
"cds_length": 1362,
"cdna_start": 1332,
"cdna_end": null,
"cdna_length": 9620,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1146C>T",
"hgvs_p": "p.Ser382Ser",
"transcript": "ENST00000467757.5",
"protein_id": "ENSP00000420463.1",
"transcript_support_level": 5,
"aa_start": 382,
"aa_end": null,
"aa_length": 453,
"cds_start": 1146,
"cds_end": null,
"cds_length": 1362,
"cdna_start": 1146,
"cdna_end": null,
"cdna_length": 1362,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1095C>T",
"hgvs_p": "p.Ser365Ser",
"transcript": "NM_001257409.2",
"protein_id": "NP_001244338.1",
"transcript_support_level": null,
"aa_start": 365,
"aa_end": null,
"aa_length": 436,
"cds_start": 1095,
"cds_end": null,
"cds_length": 1311,
"cdna_start": 1281,
"cdna_end": null,
"cdna_length": 9569,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IKZF3",
"gene_hgnc_id": 13178,
"hgvs_c": "c.1080C>T",
"hgvs_p": "p.Ser360Ser",
"transcript": "NM_183232.3",
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}
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}