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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-40264930-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=40264930&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 40264930,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_133264.5",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "NM_133264.5",
"protein_id": "NP_573571.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000323571.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_133264.5"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000323571.9",
"protein_id": "ENSP00000320924.4",
"transcript_support_level": 1,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_133264.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000323571.9"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000585043.5",
"protein_id": "ENSP00000462826.1",
"transcript_support_level": 1,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000585043.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "n.862C>T",
"hgvs_p": null,
"transcript": "ENST00000494757.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000494757.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "n.*474C>T",
"hgvs_p": null,
"transcript": "ENST00000582781.5",
"protein_id": "ENSP00000463869.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000582781.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "n.*474C>T",
"hgvs_p": null,
"transcript": "ENST00000582781.5",
"protein_id": "ENSP00000463869.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000582781.5"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000583130.5",
"protein_id": "ENSP00000462350.1",
"transcript_support_level": 2,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000583130.5"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000863500.1",
"protein_id": "ENSP00000533559.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863500.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000863503.1",
"protein_id": "ENSP00000533562.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863503.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000863504.1",
"protein_id": "ENSP00000533563.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863504.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000863505.1",
"protein_id": "ENSP00000533564.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863505.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000863506.1",
"protein_id": "ENSP00000533565.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863506.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000863507.1",
"protein_id": "ENSP00000533566.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863507.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000863508.1",
"protein_id": "ENSP00000533567.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863508.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000863509.1",
"protein_id": "ENSP00000533568.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000863509.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000922626.1",
"protein_id": "ENSP00000592685.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000922626.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000922627.1",
"protein_id": "ENSP00000592686.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000922627.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000951234.1",
"protein_id": "ENSP00000621293.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951234.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000951235.1",
"protein_id": "ENSP00000621294.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951235.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000951236.1",
"protein_id": "ENSP00000621295.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951236.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000951237.1",
"protein_id": "ENSP00000621296.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951237.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WIPF2",
"gene_hgnc_id": 30923,
"hgvs_c": "c.754C>T",
"hgvs_p": "p.Pro252Ser",
"transcript": "ENST00000951238.1",
"protein_id": "ENSP00000621297.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 440,
"cds_start": 754,
"cds_end": null,
"cds_length": 1323,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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