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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-40354331-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=40354331&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 40354331,
"ref": "C",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "NM_000964.4",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "NM_000964.4",
"protein_id": "NP_000955.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000254066.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000964.4"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000254066.10",
"protein_id": "ENSP00000254066.5",
"transcript_support_level": 1,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000964.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000254066.10"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.822C>G",
"hgvs_p": "p.Pro274Pro",
"transcript": "ENST00000394081.7",
"protein_id": "ENSP00000377643.3",
"transcript_support_level": 1,
"aa_start": 274,
"aa_end": null,
"aa_length": 457,
"cds_start": 822,
"cds_end": null,
"cds_length": 1374,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000394081.7"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.546C>G",
"hgvs_p": "p.Pro182Pro",
"transcript": "ENST00000425707.7",
"protein_id": "ENSP00000389993.3",
"transcript_support_level": 1,
"aa_start": 182,
"aa_end": null,
"aa_length": 365,
"cds_start": 546,
"cds_end": null,
"cds_length": 1098,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000425707.7"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.885C>G",
"hgvs_p": "p.Pro295Pro",
"transcript": "ENST00000394086.7",
"protein_id": "ENSP00000377648.3",
"transcript_support_level": 2,
"aa_start": 295,
"aa_end": null,
"aa_length": 478,
"cds_start": 885,
"cds_end": null,
"cds_length": 1437,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000394086.7"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.843C>G",
"hgvs_p": "p.Pro281Pro",
"transcript": "ENST00000857084.1",
"protein_id": "ENSP00000527143.1",
"transcript_support_level": null,
"aa_start": 281,
"aa_end": null,
"aa_length": 464,
"cds_start": 843,
"cds_end": null,
"cds_length": 1395,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857084.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "NM_001145301.3",
"protein_id": "NP_001138773.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145301.3"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000394089.6",
"protein_id": "ENSP00000377649.2",
"transcript_support_level": 2,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000394089.6"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000857081.1",
"protein_id": "ENSP00000527140.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857081.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000857082.1",
"protein_id": "ENSP00000527141.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857082.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000857085.1",
"protein_id": "ENSP00000527144.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857085.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000857086.1",
"protein_id": "ENSP00000527145.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857086.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000857087.1",
"protein_id": "ENSP00000527146.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857087.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000857088.1",
"protein_id": "ENSP00000527147.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857088.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000857089.1",
"protein_id": "ENSP00000527148.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857089.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000920591.1",
"protein_id": "ENSP00000590650.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000920591.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "ENST00000951717.1",
"protein_id": "ENSP00000621776.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951717.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.822C>G",
"hgvs_p": "p.Pro274Pro",
"transcript": "NM_001024809.4",
"protein_id": "NP_001019980.1",
"transcript_support_level": null,
"aa_start": 274,
"aa_end": null,
"aa_length": 457,
"cds_start": 822,
"cds_end": null,
"cds_length": 1374,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001024809.4"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.546C>G",
"hgvs_p": "p.Pro182Pro",
"transcript": "NM_001145302.3",
"protein_id": "NP_001138774.1",
"transcript_support_level": null,
"aa_start": 182,
"aa_end": null,
"aa_length": 365,
"cds_start": 546,
"cds_end": null,
"cds_length": 1098,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001145302.3"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.480C>G",
"hgvs_p": "p.Pro160Pro",
"transcript": "ENST00000475125.1",
"protein_id": "ENSP00000462514.1",
"transcript_support_level": 5,
"aa_start": 160,
"aa_end": null,
"aa_length": 185,
"cds_start": 480,
"cds_end": null,
"cds_length": 558,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000475125.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.885C>G",
"hgvs_p": "p.Pro295Pro",
"transcript": "XM_005257552.6",
"protein_id": "XP_005257609.1",
"transcript_support_level": null,
"aa_start": 295,
"aa_end": null,
"aa_length": 478,
"cds_start": 885,
"cds_end": null,
"cds_length": 1437,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005257552.6"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RARA",
"gene_hgnc_id": 9864,
"hgvs_c": "c.837C>G",
"hgvs_p": "p.Pro279Pro",
"transcript": "XM_005257553.2",
"protein_id": "XP_005257610.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 462,
"cds_start": 837,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005257553.2"
},
{
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}
],
"message": null
}