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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-41872288-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=41872288&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 41872288,
"ref": "A",
"alt": "T",
"effect": "intron_variant",
"transcript": "NM_001303274.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2643-106T>A",
"hgvs_p": null,
"transcript": "NM_001096.3",
"protein_id": "NP_001087.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1101,
"cds_start": null,
"cds_end": null,
"cds_length": 3306,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000352035.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001096.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2643-106T>A",
"hgvs_p": null,
"transcript": "ENST00000352035.7",
"protein_id": "ENSP00000253792.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1101,
"cds_start": null,
"cds_end": null,
"cds_length": 3306,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001096.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000352035.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2643-106T>A",
"hgvs_p": null,
"transcript": "ENST00000590151.5",
"protein_id": "ENSP00000466259.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1101,
"cds_start": null,
"cds_end": null,
"cds_length": 3306,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000590151.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2805-106T>A",
"hgvs_p": null,
"transcript": "NM_001303274.1",
"protein_id": "NP_001290203.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1155,
"cds_start": null,
"cds_end": null,
"cds_length": 3468,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303274.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2775-106T>A",
"hgvs_p": null,
"transcript": "NM_001303275.1",
"protein_id": "NP_001290204.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1145,
"cds_start": null,
"cds_end": null,
"cds_length": 3438,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303275.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2727-106T>A",
"hgvs_p": null,
"transcript": "ENST00000884509.1",
"protein_id": "ENSP00000554568.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1129,
"cds_start": null,
"cds_end": null,
"cds_length": 3390,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884509.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2694-106T>A",
"hgvs_p": null,
"transcript": "ENST00000937140.1",
"protein_id": "ENSP00000607199.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1118,
"cds_start": null,
"cds_end": null,
"cds_length": 3357,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937140.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2694-106T>A",
"hgvs_p": null,
"transcript": "ENST00000937146.1",
"protein_id": "ENSP00000607205.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1118,
"cds_start": null,
"cds_end": null,
"cds_length": 3357,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937146.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2643-106T>A",
"hgvs_p": null,
"transcript": "ENST00000941540.1",
"protein_id": "ENSP00000611599.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1115,
"cds_start": null,
"cds_end": null,
"cds_length": 3348,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941540.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2676-106T>A",
"hgvs_p": null,
"transcript": "ENST00000884512.1",
"protein_id": "ENSP00000554571.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1112,
"cds_start": null,
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"cds_length": 3339,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884512.1"
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2676-106T>A",
"hgvs_p": null,
"transcript": "ENST00000884516.1",
"protein_id": "ENSP00000554575.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
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"exon_count": 29,
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"gene_symbol": "ACLY",
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"hgvs_c": "c.2676-106T>A",
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"transcript": "ENST00000937136.1",
"protein_id": "ENSP00000607195.1",
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"feature": "ENST00000937136.1"
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
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"hgvs_c": "c.2667-106T>A",
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"transcript": "ENST00000941543.1",
"protein_id": "ENSP00000611602.1",
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"cdna_start": null,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
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],
"exon_rank": null,
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"gene_symbol": "ACLY",
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"hgvs_c": "c.2643-106T>A",
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"transcript": "ENST00000884502.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2643-106T>A",
"hgvs_p": null,
"transcript": "ENST00000884503.1",
"protein_id": "ENSP00000554562.1",
"transcript_support_level": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884503.1"
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 23,
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"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2643-106T>A",
"hgvs_p": null,
"transcript": "ENST00000884504.1",
"protein_id": "ENSP00000554563.1",
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"biotype": "protein_coding",
"feature": "ENST00000884504.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 30,
"intron_rank": 24,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2643-106T>A",
"hgvs_p": null,
"transcript": "ENST00000884511.1",
"protein_id": "ENSP00000554570.1",
"transcript_support_level": null,
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"biotype": "protein_coding",
"feature": "ENST00000884511.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2643-106T>A",
"hgvs_p": null,
"transcript": "ENST00000937133.1",
"protein_id": "ENSP00000607192.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000937133.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 29,
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"gene_symbol": "ACLY",
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"hgvs_c": "c.2643-106T>A",
"hgvs_p": null,
"transcript": "ENST00000937142.1",
"protein_id": "ENSP00000607201.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
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"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
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"hgvs_c": "c.2643-106T>A",
"hgvs_p": null,
"transcript": "ENST00000937145.1",
"protein_id": "ENSP00000607204.1",
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"feature": "ENST00000937145.1"
},
{
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"strand": false,
"consequences": [
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],
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"intron_rank": 24,
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"gene_symbol": "ACLY",
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"hgvs_c": "c.2643-106T>A",
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"transcript": "ENST00000941541.1",
"protein_id": "ENSP00000611600.1",
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"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000941541.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
"gene_symbol": "ACLY",
"gene_hgnc_id": 115,
"hgvs_c": "c.2640-106T>A",
"hgvs_p": null,
"transcript": "ENST00000884507.1",
"protein_id": "ENSP00000554566.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1100,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884507.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 23,
"intron_rank_end": null,
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}
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}