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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-43209941-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=43209941&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 43209941,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_005899.5",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2768A>C",
"hgvs_p": "p.His923Pro",
"transcript": "NM_005899.5",
"protein_id": "NP_005890.2",
"transcript_support_level": null,
"aa_start": 923,
"aa_end": null,
"aa_length": 966,
"cds_start": 2768,
"cds_end": null,
"cds_length": 2901,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000590996.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005899.5"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2768A>C",
"hgvs_p": "p.His923Pro",
"transcript": "ENST00000590996.6",
"protein_id": "ENSP00000466667.1",
"transcript_support_level": 1,
"aa_start": 923,
"aa_end": null,
"aa_length": 966,
"cds_start": 2768,
"cds_end": null,
"cds_length": 2901,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005899.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000590996.6"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2768A>C",
"hgvs_p": "p.His923Pro",
"transcript": "ENST00000341165.10",
"protein_id": "ENSP00000343479.5",
"transcript_support_level": 1,
"aa_start": 923,
"aa_end": null,
"aa_length": 966,
"cds_start": 2768,
"cds_end": null,
"cds_length": 2901,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000341165.10"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2822A>C",
"hgvs_p": "p.His941Pro",
"transcript": "ENST00000955671.1",
"protein_id": "ENSP00000625730.1",
"transcript_support_level": null,
"aa_start": 941,
"aa_end": null,
"aa_length": 984,
"cds_start": 2822,
"cds_end": null,
"cds_length": 2955,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955671.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2768A>C",
"hgvs_p": "p.His923Pro",
"transcript": "NM_031862.4",
"protein_id": "NP_114068.1",
"transcript_support_level": null,
"aa_start": 923,
"aa_end": null,
"aa_length": 966,
"cds_start": 2768,
"cds_end": null,
"cds_length": 2901,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_031862.4"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2768A>C",
"hgvs_p": "p.His923Pro",
"transcript": "ENST00000902841.1",
"protein_id": "ENSP00000572900.1",
"transcript_support_level": null,
"aa_start": 923,
"aa_end": null,
"aa_length": 966,
"cds_start": 2768,
"cds_end": null,
"cds_length": 2901,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902841.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2768A>C",
"hgvs_p": "p.His923Pro",
"transcript": "ENST00000955656.1",
"protein_id": "ENSP00000625715.1",
"transcript_support_level": null,
"aa_start": 923,
"aa_end": null,
"aa_length": 966,
"cds_start": 2768,
"cds_end": null,
"cds_length": 2901,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955656.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2768A>C",
"hgvs_p": "p.His923Pro",
"transcript": "ENST00000955657.1",
"protein_id": "ENSP00000625716.1",
"transcript_support_level": null,
"aa_start": 923,
"aa_end": null,
"aa_length": 966,
"cds_start": 2768,
"cds_end": null,
"cds_length": 2901,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955657.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2768A>C",
"hgvs_p": "p.His923Pro",
"transcript": "ENST00000955660.1",
"protein_id": "ENSP00000625719.1",
"transcript_support_level": null,
"aa_start": 923,
"aa_end": null,
"aa_length": 966,
"cds_start": 2768,
"cds_end": null,
"cds_length": 2901,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955660.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2768A>C",
"hgvs_p": "p.His923Pro",
"transcript": "ENST00000955661.1",
"protein_id": "ENSP00000625720.1",
"transcript_support_level": null,
"aa_start": 923,
"aa_end": null,
"aa_length": 966,
"cds_start": 2768,
"cds_end": null,
"cds_length": 2901,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955661.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2765A>C",
"hgvs_p": "p.His922Pro",
"transcript": "ENST00000955664.1",
"protein_id": "ENSP00000625723.1",
"transcript_support_level": null,
"aa_start": 922,
"aa_end": null,
"aa_length": 965,
"cds_start": 2765,
"cds_end": null,
"cds_length": 2898,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955664.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2726A>C",
"hgvs_p": "p.His909Pro",
"transcript": "ENST00000955672.1",
"protein_id": "ENSP00000625731.1",
"transcript_support_level": null,
"aa_start": 909,
"aa_end": null,
"aa_length": 952,
"cds_start": 2726,
"cds_end": null,
"cds_length": 2859,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955672.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2705A>C",
"hgvs_p": "p.His902Pro",
"transcript": "ENST00000902839.1",
"protein_id": "ENSP00000572898.1",
"transcript_support_level": null,
"aa_start": 902,
"aa_end": null,
"aa_length": 945,
"cds_start": 2705,
"cds_end": null,
"cds_length": 2838,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902839.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2705A>C",
"hgvs_p": "p.His902Pro",
"transcript": "ENST00000902840.1",
"protein_id": "ENSP00000572899.1",
"transcript_support_level": null,
"aa_start": 902,
"aa_end": null,
"aa_length": 945,
"cds_start": 2705,
"cds_end": null,
"cds_length": 2838,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902840.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2657A>C",
"hgvs_p": "p.His886Pro",
"transcript": "ENST00000955669.1",
"protein_id": "ENSP00000625728.1",
"transcript_support_level": null,
"aa_start": 886,
"aa_end": null,
"aa_length": 929,
"cds_start": 2657,
"cds_end": null,
"cds_length": 2790,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955669.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2615A>C",
"hgvs_p": "p.His872Pro",
"transcript": "ENST00000955659.1",
"protein_id": "ENSP00000625718.1",
"transcript_support_level": null,
"aa_start": 872,
"aa_end": null,
"aa_length": 915,
"cds_start": 2615,
"cds_end": null,
"cds_length": 2748,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955659.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2615A>C",
"hgvs_p": "p.His872Pro",
"transcript": "ENST00000955668.1",
"protein_id": "ENSP00000625727.1",
"transcript_support_level": null,
"aa_start": 872,
"aa_end": null,
"aa_length": 915,
"cds_start": 2615,
"cds_end": null,
"cds_length": 2748,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955668.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2603A>C",
"hgvs_p": "p.His868Pro",
"transcript": "ENST00000955662.1",
"protein_id": "ENSP00000625721.1",
"transcript_support_level": null,
"aa_start": 868,
"aa_end": null,
"aa_length": 911,
"cds_start": 2603,
"cds_end": null,
"cds_length": 2736,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955662.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2600A>C",
"hgvs_p": "p.His867Pro",
"transcript": "ENST00000955665.1",
"protein_id": "ENSP00000625724.1",
"transcript_support_level": null,
"aa_start": 867,
"aa_end": null,
"aa_length": 910,
"cds_start": 2600,
"cds_end": null,
"cds_length": 2733,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955665.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2573A>C",
"hgvs_p": "p.His858Pro",
"transcript": "ENST00000955670.1",
"protein_id": "ENSP00000625729.1",
"transcript_support_level": null,
"aa_start": 858,
"aa_end": null,
"aa_length": 901,
"cds_start": 2573,
"cds_end": null,
"cds_length": 2706,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955670.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2558A>C",
"hgvs_p": "p.His853Pro",
"transcript": "ENST00000928838.1",
"protein_id": "ENSP00000598897.1",
"transcript_support_level": null,
"aa_start": 853,
"aa_end": null,
"aa_length": 896,
"cds_start": 2558,
"cds_end": null,
"cds_length": 2691,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928838.1"
},
{
"aa_ref": "H",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NBR1",
"gene_hgnc_id": 6746,
"hgvs_c": "c.2558A>C",
"hgvs_p": "p.His853Pro",
"transcript": "ENST00000955658.1",
"protein_id": "ENSP00000625717.1",
"transcript_support_level": null,
"aa_start": 853,
"aa_end": null,
"aa_length": 896,
"cds_start": 2558,
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}