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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-44148179-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=44148179&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 44148179,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000585683.6",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "NM_001171251.3",
"protein_id": "NP_001164722.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 646,
"cds_start": 376,
"cds_end": null,
"cds_length": 1941,
"cdna_start": 589,
"cdna_end": null,
"cdna_length": 2698,
"mane_select": "ENST00000585683.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "ENST00000585683.6",
"protein_id": "ENSP00000466618.1",
"transcript_support_level": 2,
"aa_start": 126,
"aa_end": null,
"aa_length": 646,
"cds_start": 376,
"cds_end": null,
"cds_length": 1941,
"cdna_start": 589,
"cdna_end": null,
"cdna_length": 2698,
"mane_select": "NM_001171251.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "ENST00000319977.8",
"protein_id": "ENSP00000313500.4",
"transcript_support_level": 1,
"aa_start": 126,
"aa_end": null,
"aa_length": 647,
"cds_start": 376,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 613,
"cdna_end": null,
"cdna_length": 2725,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "ENST00000245382.6",
"protein_id": "ENSP00000245382.5",
"transcript_support_level": 1,
"aa_start": 126,
"aa_end": null,
"aa_length": 521,
"cds_start": 376,
"cds_end": null,
"cds_length": 1566,
"cdna_start": 497,
"cdna_end": null,
"cdna_length": 2272,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "NM_024032.5",
"protein_id": "NP_076937.2",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 647,
"cds_start": 376,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 589,
"cdna_end": null,
"cdna_length": 2701,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "NM_001321311.2",
"protein_id": "NP_001308240.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 645,
"cds_start": 376,
"cds_end": null,
"cds_length": 1938,
"cdna_start": 589,
"cdna_end": null,
"cdna_length": 2695,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "NM_001321310.2",
"protein_id": "NP_001308239.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 521,
"cds_start": 376,
"cds_end": null,
"cds_length": 1566,
"cdna_start": 589,
"cdna_end": null,
"cdna_length": 2364,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_011525187.3",
"protein_id": "XP_011523489.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 646,
"cds_start": 376,
"cds_end": null,
"cds_length": 1941,
"cdna_start": 589,
"cdna_end": null,
"cdna_length": 2698,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_011525188.3",
"protein_id": "XP_011523490.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 619,
"cds_start": 376,
"cds_end": null,
"cds_length": 1860,
"cdna_start": 589,
"cdna_end": null,
"cdna_length": 2617,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_047436676.1",
"protein_id": "XP_047292632.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 618,
"cds_start": 376,
"cds_end": null,
"cds_length": 1857,
"cdna_start": 589,
"cdna_end": null,
"cdna_length": 2614,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_011525189.3",
"protein_id": "XP_011523491.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 600,
"cds_start": 376,
"cds_end": null,
"cds_length": 1803,
"cdna_start": 589,
"cdna_end": null,
"cdna_length": 2560,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_011525190.3",
"protein_id": "XP_011523492.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 599,
"cds_start": 376,
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"cds_length": 1800,
"cdna_start": 589,
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"cdna_length": 2557,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_047436677.1",
"protein_id": "XP_047292633.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 599,
"cds_start": 376,
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"cdna_start": 589,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
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"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_047436678.1",
"protein_id": "XP_047292634.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
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"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_011525191.4",
"protein_id": "XP_011523493.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 597,
"cds_start": 376,
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"cdna_start": 589,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_047436679.1",
"protein_id": "XP_047292635.1",
"transcript_support_level": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_047436680.1",
"protein_id": "XP_047292636.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 595,
"cds_start": 376,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "T",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_011525192.3",
"protein_id": "XP_011523494.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 582,
"cds_start": 376,
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"cdna_start": 589,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "T",
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 3,
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"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_047436681.1",
"protein_id": "XP_047292637.1",
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},
{
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"protein_coding": true,
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"consequences": [
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],
"exon_rank": 3,
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"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_047436682.1",
"protein_id": "XP_047292638.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
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"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_011525193.3",
"protein_id": "XP_011523495.1",
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_047436683.1",
"protein_id": "XP_047292639.1",
"transcript_support_level": null,
"aa_start": 126,
"aa_end": null,
"aa_length": 569,
"cds_start": 376,
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"cdna_start": 589,
"cdna_end": null,
"cdna_length": 2003,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HROB",
"gene_hgnc_id": 28460,
"hgvs_c": "c.376A>G",
"hgvs_p": "p.Thr126Ala",
"transcript": "XM_047436684.1",
"protein_id": "XP_047292640.1",
"transcript_support_level": null,
"aa_start": 126,
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