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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-45169741-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=45169741&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 45169741,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001303436.1",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "NM_001303441.2",
"protein_id": "NP_001290370.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000589230.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303441.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000589230.6",
"protein_id": "ENSP00000466200.2",
"transcript_support_level": 2,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001303441.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000589230.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000591576.5",
"protein_id": "ENSP00000465727.1",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000591576.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000592695.1",
"protein_id": "ENSP00000467517.1",
"transcript_support_level": 1,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000592695.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.859C>G",
"hgvs_p": "p.Arg287Gly",
"transcript": "NM_001303436.1",
"protein_id": "NP_001290365.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 308,
"cds_start": 859,
"cds_end": null,
"cds_length": 927,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303436.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "NM_001303437.1",
"protein_id": "NP_001290366.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303437.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "NM_001303438.1",
"protein_id": "NP_001290367.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303438.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "NM_001303439.1",
"protein_id": "NP_001290368.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303439.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "NM_001303440.2",
"protein_id": "NP_001290369.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303440.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "NM_001303442.2",
"protein_id": "NP_001290371.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303442.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "NM_001303443.2",
"protein_id": "NP_001290372.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303443.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "NM_001303444.2",
"protein_id": "NP_001290373.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001303444.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "NM_144608.2",
"protein_id": "NP_653209.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_144608.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000307275.7",
"protein_id": "ENSP00000302276.2",
"transcript_support_level": 2,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000307275.7"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000585340.2",
"protein_id": "ENSP00000468251.2",
"transcript_support_level": 3,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000585340.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000586681.6",
"protein_id": "ENSP00000465086.2",
"transcript_support_level": 2,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000586681.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000591070.6",
"protein_id": "ENSP00000464807.2",
"transcript_support_level": 3,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000591070.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000593138.6",
"protein_id": "ENSP00000468773.2",
"transcript_support_level": 3,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000593138.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000894989.1",
"protein_id": "ENSP00000565048.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894989.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000894990.1",
"protein_id": "ENSP00000565049.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894990.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000894991.1",
"protein_id": "ENSP00000565050.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894991.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "HEXIM2",
"gene_hgnc_id": 28591,
"hgvs_c": "c.793C>G",
"hgvs_p": "p.Arg265Gly",
"transcript": "ENST00000894992.1",
"protein_id": "ENSP00000565051.1",
"transcript_support_level": null,
"aa_start": 265,
"aa_end": null,
"aa_length": 286,
"cds_start": 793,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}
],
"message": null
}