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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-46751565-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=46751565&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 46751565,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_006178.4",
"consequences": [
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2106G>A",
"hgvs_p": "p.Lys702Lys",
"transcript": "NM_006178.4",
"protein_id": "NP_006169.2",
"transcript_support_level": null,
"aa_start": 702,
"aa_end": null,
"aa_length": 744,
"cds_start": 2106,
"cds_end": null,
"cds_length": 2235,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000398238.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006178.4"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2106G>A",
"hgvs_p": "p.Lys702Lys",
"transcript": "ENST00000398238.8",
"protein_id": "ENSP00000381293.4",
"transcript_support_level": 1,
"aa_start": 702,
"aa_end": null,
"aa_length": 744,
"cds_start": 2106,
"cds_end": null,
"cds_length": 2235,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_006178.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000398238.8"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2106G>A",
"hgvs_p": "p.Lys702Lys",
"transcript": "ENST00000465370.2",
"protein_id": "ENSP00000467779.2",
"transcript_support_level": 5,
"aa_start": 702,
"aa_end": null,
"aa_length": 769,
"cds_start": 2106,
"cds_end": null,
"cds_length": 2310,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000465370.2"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2106G>A",
"hgvs_p": "p.Lys702Lys",
"transcript": "ENST00000706392.1",
"protein_id": "ENSP00000516369.1",
"transcript_support_level": null,
"aa_start": 702,
"aa_end": null,
"aa_length": 744,
"cds_start": 2106,
"cds_end": null,
"cds_length": 2235,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000706392.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2106G>A",
"hgvs_p": "p.Lys702Lys",
"transcript": "ENST00000706391.1",
"protein_id": "ENSP00000516368.1",
"transcript_support_level": null,
"aa_start": 702,
"aa_end": null,
"aa_length": 743,
"cds_start": 2106,
"cds_end": null,
"cds_length": 2232,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000706391.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2106G>A",
"hgvs_p": "p.Lys702Lys",
"transcript": "ENST00000706373.1",
"protein_id": "ENSP00000516356.1",
"transcript_support_level": null,
"aa_start": 702,
"aa_end": null,
"aa_length": 742,
"cds_start": 2106,
"cds_end": null,
"cds_length": 2229,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000706373.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2097G>A",
"hgvs_p": "p.Lys699Lys",
"transcript": "ENST00000891010.1",
"protein_id": "ENSP00000561069.1",
"transcript_support_level": null,
"aa_start": 699,
"aa_end": null,
"aa_length": 741,
"cds_start": 2097,
"cds_end": null,
"cds_length": 2226,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891010.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2091G>A",
"hgvs_p": "p.Lys697Lys",
"transcript": "ENST00000575068.5",
"protein_id": "ENSP00000458221.1",
"transcript_support_level": 2,
"aa_start": 697,
"aa_end": null,
"aa_length": 739,
"cds_start": 2091,
"cds_end": null,
"cds_length": 2220,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000575068.5"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2091G>A",
"hgvs_p": "p.Lys697Lys",
"transcript": "ENST00000576040.6",
"protein_id": "ENSP00000460152.2",
"transcript_support_level": 4,
"aa_start": 697,
"aa_end": null,
"aa_length": 739,
"cds_start": 2091,
"cds_end": null,
"cds_length": 2220,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000576040.6"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2091G>A",
"hgvs_p": "p.Lys697Lys",
"transcript": "ENST00000706400.1",
"protein_id": "ENSP00000516376.1",
"transcript_support_level": null,
"aa_start": 697,
"aa_end": null,
"aa_length": 739,
"cds_start": 2091,
"cds_end": null,
"cds_length": 2220,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000706400.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2106G>A",
"hgvs_p": "p.Lys702Lys",
"transcript": "ENST00000706393.1",
"protein_id": "ENSP00000516370.1",
"transcript_support_level": null,
"aa_start": 702,
"aa_end": null,
"aa_length": 738,
"cds_start": 2106,
"cds_end": null,
"cds_length": 2217,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000706393.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.2031G>A",
"hgvs_p": "p.Lys677Lys",
"transcript": "ENST00000946851.1",
"protein_id": "ENSP00000616910.1",
"transcript_support_level": null,
"aa_start": 677,
"aa_end": null,
"aa_length": 719,
"cds_start": 2031,
"cds_end": null,
"cds_length": 2160,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000946851.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.1995G>A",
"hgvs_p": "p.Lys665Lys",
"transcript": "ENST00000891011.1",
"protein_id": "ENSP00000561070.1",
"transcript_support_level": null,
"aa_start": 665,
"aa_end": null,
"aa_length": 707,
"cds_start": 1995,
"cds_end": null,
"cds_length": 2124,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891011.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.1971G>A",
"hgvs_p": "p.Lys657Lys",
"transcript": "ENST00000891012.1",
"protein_id": "ENSP00000561071.1",
"transcript_support_level": null,
"aa_start": 657,
"aa_end": null,
"aa_length": 699,
"cds_start": 1971,
"cds_end": null,
"cds_length": 2100,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891012.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.1824G>A",
"hgvs_p": "p.Lys608Lys",
"transcript": "ENST00000706399.1",
"protein_id": "ENSP00000516375.1",
"transcript_support_level": null,
"aa_start": 608,
"aa_end": null,
"aa_length": 650,
"cds_start": 1824,
"cds_end": null,
"cds_length": 1953,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000706399.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.1815G>A",
"hgvs_p": "p.Lys605Lys",
"transcript": "ENST00000706396.1",
"protein_id": "ENSP00000516372.1",
"transcript_support_level": null,
"aa_start": 605,
"aa_end": null,
"aa_length": 647,
"cds_start": 1815,
"cds_end": null,
"cds_length": 1944,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000706396.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.1719G>A",
"hgvs_p": "p.Lys573Lys",
"transcript": "ENST00000706395.1",
"protein_id": "ENSP00000516371.1",
"transcript_support_level": null,
"aa_start": 573,
"aa_end": null,
"aa_length": 615,
"cds_start": 1719,
"cds_end": null,
"cds_length": 1848,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000706395.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "c.1668G>A",
"hgvs_p": "p.Lys556Lys",
"transcript": "ENST00000706398.1",
"protein_id": "ENSP00000516374.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 598,
"cds_start": 1668,
"cds_end": null,
"cds_length": 1797,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000706398.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "LRRC37A2",
"gene_hgnc_id": 32404,
"hgvs_c": "c.4809+201046G>A",
"hgvs_p": null,
"transcript": "XM_024450773.2",
"protein_id": "XP_024306541.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1604,
"cds_start": null,
"cds_end": null,
"cds_length": 4815,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024450773.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "n.*1820G>A",
"hgvs_p": null,
"transcript": "ENST00000571864.6",
"protein_id": "ENSP00000461448.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000571864.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "n.692G>A",
"hgvs_p": null,
"transcript": "ENST00000576346.6",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000576346.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSF",
"gene_hgnc_id": 8016,
"hgvs_c": "n.2188G>A",
"hgvs_p": null,
"transcript": "ENST00000706374.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000706374.1"
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}
],
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}