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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-4719585-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=4719585&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 4719585,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000269260.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.917+165A>G",
"hgvs_p": null,
"transcript": "NM_004313.4",
"protein_id": "NP_004304.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 409,
"cds_start": -4,
"cds_end": null,
"cds_length": 1230,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1778,
"mane_select": "ENST00000269260.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.917+165A>G",
"hgvs_p": null,
"transcript": "ENST00000269260.7",
"protein_id": "ENSP00000269260.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 409,
"cds_start": -4,
"cds_end": null,
"cds_length": 1230,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1778,
"mane_select": "NM_004313.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.341+165A>G",
"hgvs_p": null,
"transcript": "ENST00000574954.5",
"protein_id": "ENSP00000466344.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 217,
"cds_start": -4,
"cds_end": null,
"cds_length": 654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1348,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.980+165A>G",
"hgvs_p": null,
"transcript": "NM_001257328.2",
"protein_id": "NP_001244257.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 430,
"cds_start": -4,
"cds_end": null,
"cds_length": 1293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1841,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.980+165A>G",
"hgvs_p": null,
"transcript": "ENST00000412477.7",
"protein_id": "ENSP00000403701.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 430,
"cds_start": -4,
"cds_end": null,
"cds_length": 1293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1779,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.917+165A>G",
"hgvs_p": null,
"transcript": "NM_001257330.2",
"protein_id": "NP_001244259.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 421,
"cds_start": -4,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1814,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.872+165A>G",
"hgvs_p": null,
"transcript": "NM_001257331.2",
"protein_id": "NP_001244260.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": -4,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1769,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.872+165A>G",
"hgvs_p": null,
"transcript": "ENST00000346341.6",
"protein_id": "ENSP00000341895.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 406,
"cds_start": -4,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1769,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.872+165A>G",
"hgvs_p": null,
"transcript": "NM_199004.2",
"protein_id": "NP_945355.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 394,
"cds_start": -4,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1733,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.872+165A>G",
"hgvs_p": null,
"transcript": "ENST00000381488.10",
"protein_id": "ENSP00000370898.6",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 394,
"cds_start": -4,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1236,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.786+296A>G",
"hgvs_p": null,
"transcript": "NM_001257329.2",
"protein_id": "NP_001244258.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 330,
"cds_start": -4,
"cds_end": null,
"cds_length": 993,
"cdna_start": null,
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"cdna_length": 1647,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.786+296A>G",
"hgvs_p": null,
"transcript": "ENST00000575877.5",
"protein_id": "ENSP00000466857.1",
"transcript_support_level": 5,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.341+165A>G",
"hgvs_p": null,
"transcript": "NM_001330064.2",
"protein_id": "NP_001316993.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 217,
"cds_start": -4,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.341+165A>G",
"hgvs_p": null,
"transcript": "ENST00000571206.1",
"protein_id": "ENSP00000460607.1",
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"aa_start": null,
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"cds_start": -4,
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},
{
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"strand": true,
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],
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"gene_symbol": "ARRB2",
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"hgvs_c": "c.341+165A>G",
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"transcript": "ENST00000572457.5",
"protein_id": "ENSP00000465296.1",
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "n.*208+165A>G",
"hgvs_p": null,
"transcript": "ENST00000576235.1",
"protein_id": "ENSP00000460879.1",
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"aa_start": null,
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},
{
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],
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"intron_rank": 1,
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"gene_symbol": "ENSG00000302420",
"gene_hgnc_id": null,
"hgvs_c": "n.38-1856T>C",
"hgvs_p": null,
"transcript": "ENST00000786504.1",
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ENSG00000302420",
"gene_hgnc_id": null,
"hgvs_c": "n.132-100T>C",
"hgvs_p": null,
"transcript": "ENST00000786505.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ENSG00000302420",
"gene_hgnc_id": null,
"hgvs_c": "n.48-418T>C",
"hgvs_p": null,
"transcript": "ENST00000786506.1",
"protein_id": null,
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},
{
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"protein_coding": false,
"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "n.976+165A>G",
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"transcript": "NR_047516.2",
"protein_id": null,
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},
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
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"hgvs_c": "c.1010+165A>G",
"hgvs_p": null,
"transcript": "XM_011523858.3",
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},
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 10,
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"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.341+165A>G",
"hgvs_p": null,
"transcript": "XM_017024645.2",
"protein_id": "XP_016880134.1",
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"aa_start": null,
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"aa_length": 229,
"cds_start": -4,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "ARRB2",
"gene_hgnc_id": 712,
"hgvs_c": "c.341+165A>G",
"hgvs_p": null,
"transcript": "XM_024450752.2",
"protein_id": "XP_024306520.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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}
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}