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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-47597321-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=47597321&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 47597321,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000322157.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "c.1536+859A>G",
"hgvs_p": null,
"transcript": "NM_006310.4",
"protein_id": "NP_006301.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 919,
"cds_start": -4,
"cds_end": null,
"cds_length": 2760,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4309,
"mane_select": "ENST00000322157.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "c.1536+859A>G",
"hgvs_p": null,
"transcript": "ENST00000322157.9",
"protein_id": "ENSP00000320324.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 919,
"cds_start": -4,
"cds_end": null,
"cds_length": 2760,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4309,
"mane_select": "NM_006310.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "c.1536+859A>G",
"hgvs_p": null,
"transcript": "NM_001411130.1",
"protein_id": "NP_001398059.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 924,
"cds_start": -4,
"cds_end": null,
"cds_length": 2775,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4404,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "c.1536+859A>G",
"hgvs_p": null,
"transcript": "ENST00000677370.1",
"protein_id": "ENSP00000503738.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 924,
"cds_start": -4,
"cds_end": null,
"cds_length": 2775,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4226,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "c.1536+859A>G",
"hgvs_p": null,
"transcript": "ENST00000677120.1",
"protein_id": "ENSP00000503682.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 919,
"cds_start": -4,
"cds_end": null,
"cds_length": 2760,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3758,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "c.1524+859A>G",
"hgvs_p": null,
"transcript": "NM_001330257.2",
"protein_id": "NP_001317186.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 915,
"cds_start": -4,
"cds_end": null,
"cds_length": 2748,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4158,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "c.1524+859A>G",
"hgvs_p": null,
"transcript": "ENST00000530173.6",
"protein_id": "ENSP00000433287.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 915,
"cds_start": -4,
"cds_end": null,
"cds_length": 2748,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4134,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.*253+859A>G",
"hgvs_p": null,
"transcript": "ENST00000530514.6",
"protein_id": "ENSP00000436733.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3251,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.396+859A>G",
"hgvs_p": null,
"transcript": "ENST00000534807.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 838,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.1537+859A>G",
"hgvs_p": null,
"transcript": "ENST00000676492.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4559,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.*1934+859A>G",
"hgvs_p": null,
"transcript": "ENST00000677226.1",
"protein_id": "ENSP00000504389.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5056,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.1536+859A>G",
"hgvs_p": null,
"transcript": "ENST00000677664.1",
"protein_id": "ENSP00000503284.1",
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"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 4590,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.*1103+859A>G",
"hgvs_p": null,
"transcript": "ENST00000677710.1",
"protein_id": "ENSP00000504357.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.1536+859A>G",
"hgvs_p": null,
"transcript": "ENST00000678262.1",
"protein_id": "ENSP00000503773.1",
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"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 22,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.*596+859A>G",
"hgvs_p": null,
"transcript": "ENST00000678461.1",
"protein_id": "ENSP00000504752.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.2399+859A>G",
"hgvs_p": null,
"transcript": "ENST00000678496.1",
"protein_id": null,
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},
{
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"strand": true,
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],
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"intron_rank": 4,
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"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.342+859A>G",
"hgvs_p": null,
"transcript": "ENST00000678902.1",
"protein_id": "ENSP00000504519.1",
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.*1670+859A>G",
"hgvs_p": null,
"transcript": "ENST00000678909.1",
"protein_id": "ENSP00000503450.1",
"transcript_support_level": null,
"aa_start": null,
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"mane_select": null,
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"biotype": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.1568+859A>G",
"hgvs_p": null,
"transcript": "ENST00000700479.1",
"protein_id": null,
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},
{
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],
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"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
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},
{
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"strand": true,
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],
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"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
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},
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 24,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.1536+859A>G",
"hgvs_p": null,
"transcript": "ENST00000700497.1",
"protein_id": "ENSP00000515023.1",
"transcript_support_level": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "NPEPPS",
"gene_hgnc_id": 7900,
"hgvs_c": "n.1568+859A>G",
"hgvs_p": null,
"transcript": "ENST00000700498.1",
"protein_id": null,
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"aa_length": null,
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"mane_select": null,
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"feature": null
},
{
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}
],
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}