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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-49404263-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=49404263&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 49404263,
"ref": "G",
"alt": "T",
"effect": "3_prime_UTR_variant",
"transcript": "NM_002634.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "NM_002634.4",
"protein_id": "NP_002625.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1834,
"mane_select": "ENST00000300408.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002634.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000300408.8",
"protein_id": "ENSP00000300408.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1834,
"mane_select": "NM_002634.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000300408.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000511832.6",
"protein_id": "ENSP00000425035.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1847,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000511832.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "NM_001281496.2",
"protein_id": "NP_001268425.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1929,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001281496.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "NM_001281715.2",
"protein_id": "NP_001268644.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1926,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001281715.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000419140.7",
"protein_id": "ENSP00000393320.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1867,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000419140.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000504124.6",
"protein_id": "ENSP00000426433.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1899,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000504124.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000614445.5",
"protein_id": "ENSP00000479488.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1908,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000614445.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000617874.5",
"protein_id": "ENSP00000484113.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1885,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000617874.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000903592.1",
"protein_id": "ENSP00000573651.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2425,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903592.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000903593.1",
"protein_id": "ENSP00000573652.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 272,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": 1958,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000903593.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "PHB1",
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"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000903594.1",
"protein_id": "ENSP00000573653.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 272,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000903594.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "PHB1",
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"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000903595.1",
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"aa_start": null,
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"aa_length": 272,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000903595.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "PHB1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
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"exon_count": 7,
"intron_rank": null,
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"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000929390.1",
"protein_id": "ENSP00000599449.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000929390.1"
},
{
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"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
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"gene_symbol": "PHB1",
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"hgvs_c": "c.*729C>A",
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"transcript": "ENST00000929394.1",
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"mane_select": null,
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"biotype": "protein_coding",
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},
{
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"strand": false,
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],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
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"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
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"transcript": "ENST00000929391.1",
"protein_id": "ENSP00000599450.1",
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000929391.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000929395.1",
"protein_id": "ENSP00000599454.1",
"transcript_support_level": null,
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"cds_start": null,
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"mane_select": null,
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},
{
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"strand": false,
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],
"exon_rank": 7,
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"intron_rank": null,
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"gene_symbol": "PHB1",
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"hgvs_c": "c.*729C>A",
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},
{
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"protein_coding": true,
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],
"exon_rank": 6,
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"exon_count": 6,
"intron_rank": null,
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"gene_symbol": "PHB1",
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"protein_id": "ENSP00000599451.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 5,
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"exon_count": 5,
"intron_rank": null,
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"gene_symbol": "PHB1",
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"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "ENST00000446735.6",
"protein_id": "ENSP00000407828.2",
"transcript_support_level": 5,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000446735.6"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHB1",
"gene_hgnc_id": 8912,
"hgvs_c": "c.*729C>A",
"hgvs_p": null,
"transcript": "NM_001281497.2",
"protein_id": "NP_001268426.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 155,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001281497.2"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
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{
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}
],
"message": null
}