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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-4944792-CG-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=4944792&ref=CG&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "17",
      "pos": 4944792,
      "ref": "CG",
      "alt": "C",
      "effect": "frameshift_variant",
      "transcript": "ENST00000262482.11",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RNF167",
          "gene_hgnc_id": 24544,
          "hgvs_c": "c.833delG",
          "hgvs_p": "p.Gly278fs",
          "transcript": "NM_015528.3",
          "protein_id": "NP_056343.1",
          "transcript_support_level": null,
          "aa_start": 278,
          "aa_end": null,
          "aa_length": 350,
          "cds_start": 833,
          "cds_end": null,
          "cds_length": 1053,
          "cdna_start": 1349,
          "cdna_end": null,
          "cdna_length": 1775,
          "mane_select": "ENST00000262482.11",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RNF167",
          "gene_hgnc_id": 24544,
          "hgvs_c": "c.833delG",
          "hgvs_p": "p.Gly278fs",
          "transcript": "ENST00000262482.11",
          "protein_id": "ENSP00000262482.6",
          "transcript_support_level": 2,
          "aa_start": 278,
          "aa_end": null,
          "aa_length": 350,
          "cds_start": 833,
          "cds_end": null,
          "cds_length": 1053,
          "cdna_start": 1349,
          "cdna_end": null,
          "cdna_length": 1775,
          "mane_select": "NM_015528.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RNF167",
          "gene_hgnc_id": 24544,
          "hgvs_c": "c.833delG",
          "hgvs_p": "p.Gly278fs",
          "transcript": "ENST00000575111.5",
          "protein_id": "ENSP00000460190.1",
          "transcript_support_level": 1,
          "aa_start": 278,
          "aa_end": null,
          "aa_length": 350,
          "cds_start": 833,
          "cds_end": null,
          "cds_length": 1053,
          "cdna_start": 1362,
          "cdna_end": null,
          "cdna_length": 1757,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RNF167",
          "gene_hgnc_id": 24544,
          "hgvs_c": "c.905delG",
          "hgvs_p": "p.Gly302fs",
          "transcript": "NM_001370303.1",
          "protein_id": "NP_001357232.1",
          "transcript_support_level": null,
          "aa_start": 302,
          "aa_end": null,
          "aa_length": 374,
          "cds_start": 905,
          "cds_end": null,
          "cds_length": 1125,
          "cdna_start": 1467,
          "cdna_end": null,
          "cdna_length": 1893,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RNF167",
          "gene_hgnc_id": 24544,
          "hgvs_c": "c.905delG",
          "hgvs_p": "p.Gly302fs",
          "transcript": "NM_001370304.1",
          "protein_id": "NP_001357233.1",
          "transcript_support_level": null,
          "aa_start": 302,
          "aa_end": null,
          "aa_length": 374,
          "cds_start": 905,
          "cds_end": null,
          "cds_length": 1125,
          "cdna_start": 1275,
          "cdna_end": null,
          "cdna_length": 1701,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RNF167",
          "gene_hgnc_id": 24544,
          "hgvs_c": "c.833delG",
          "hgvs_p": "p.Gly278fs",
          "transcript": "NM_001320356.2",
          "protein_id": "NP_001307285.1",
          "transcript_support_level": null,
          "aa_start": 278,
          "aa_end": null,
          "aa_length": 350,
          "cds_start": 833,
          "cds_end": null,
          "cds_length": 1053,
          "cdna_start": 1249,
          "cdna_end": null,
          "cdna_length": 1675,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RNF167",
          "gene_hgnc_id": 24544,
          "hgvs_c": "c.833delG",
          "hgvs_p": "p.Gly278fs",
          "transcript": "NM_001320357.2",
          "protein_id": "NP_001307286.1",
          "transcript_support_level": null,
          "aa_start": 278,
          "aa_end": null,
          "aa_length": 350,
          "cds_start": 833,
          "cds_end": null,
          "cds_length": 1053,
          "cdna_start": 963,
          "cdna_end": null,
          "cdna_length": 1389,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RNF167",
          "gene_hgnc_id": 24544,
          "hgvs_c": "c.833delG",
          "hgvs_p": "p.Gly278fs",
          "transcript": "NM_001320358.2",
          "protein_id": "NP_001307287.1",
          "transcript_support_level": null,
          "aa_start": 278,
          "aa_end": null,
          "aa_length": 350,
          "cds_start": 833,
          "cds_end": null,
          "cds_length": 1053,
          "cdna_start": 1009,
          "cdna_end": null,
          "cdna_length": 1435,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "G",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RNF167",
          "gene_hgnc_id": 24544,
          "hgvs_c": "c.833delG",
          "hgvs_p": "p.Gly278fs",
          "transcript": "NM_001320359.2",
          "protein_id": "NP_001307288.1",
          "transcript_support_level": null,
          "aa_start": 278,
          "aa_end": null,
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          "cdna_start": 1165,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 10,
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          "exon_count": 10,
          "intron_rank": null,
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          "gene_symbol": "RNF167",
          "gene_hgnc_id": 24544,
          "hgvs_c": "c.833delG",
          "hgvs_p": "p.Gly278fs",
          "transcript": "NM_001320360.2",
          "protein_id": "NP_001307289.1",
          "transcript_support_level": null,
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        {
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          "intron_rank": null,
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          "gene_symbol": "RNF167",
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          "transcript": "ENST00000571816.5",
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        {
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          "gene_symbol": "RNF167",
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          "transcript": "NM_001370306.1",
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        {
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          ],
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          "intron_rank": null,
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          "gene_symbol": "RNF167",
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      "gene_symbol": "RNF167",
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      "dbsnp": "rs1057519428",
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      "gnomad_exomes_af": 0.00000136986,
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      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "bayesdelnoaf_score": null,
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      "phylop100way_score": 0.563,
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      "spliceai_max_score": 0,
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      "acmg_score": 2,
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      "acmg_criteria": "PM2",
      "acmg_by_gene": [
        {
          "score": 2,
          "benign_score": 0,
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          "verdict": "Uncertain_significance",
          "transcript": "ENST00000262482.11",
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          "hgvs_p": "p.Gly278fs"
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      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}