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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-49619327-A-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=49619327&ref=A&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM1",
            "PM2",
            "PP2",
            "PP3_Strong"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "SPOP",
          "hgnc_id": 11254,
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "inheritance_mode": "AD",
          "pathogenic_score": 9,
          "score": 9,
          "transcript": "NM_003563.3",
          "verdict": "Likely_pathogenic"
        }
      ],
      "acmg_classification": "Likely_pathogenic",
      "acmg_criteria": "PM1,PM2,PP2,PP3_Strong",
      "acmg_score": 9,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.996,
      "alt": "C",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Pathogenic",
      "bayesdelnoaf_score": 0.31,
      "chr": "17",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "Prostate cancer",
      "clinvar_review_status": "no assertion criteria provided",
      "clinvar_submissions_summary": "null",
      "computational_prediction_selected": "Pathogenic",
      "computational_score_selected": 0.941249430179596,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2850,
          "cdna_start": 490,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_001007228.2",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000504102.6",
          "protein_coding": true,
          "protein_id": "NP_001007229.1",
          "strand": false,
          "transcript": "NM_001007228.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2850,
          "cdna_start": 490,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000504102.6",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001007228.2",
          "protein_coding": true,
          "protein_id": "ENSP00000425905.1",
          "strand": false,
          "transcript": "ENST00000504102.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2985,
          "cdna_start": 625,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000393328.6",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000377001.2",
          "strand": false,
          "transcript": "ENST00000393328.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3090,
          "cdna_start": 730,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "NM_001007226.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001007227.1",
          "strand": false,
          "transcript": "NM_001007226.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2968,
          "cdna_start": 608,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_001007227.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001007228.1",
          "strand": false,
          "transcript": "NM_001007227.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2967,
          "cdna_start": 607,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_001007229.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001007230.1",
          "strand": false,
          "transcript": "NM_001007229.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3019,
          "cdna_start": 659,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "NM_001007230.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001007231.1",
          "strand": false,
          "transcript": "NM_001007230.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3139,
          "cdna_start": 779,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_001370730.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001357659.1",
          "strand": false,
          "transcript": "NM_001370730.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3088,
          "cdna_start": 728,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_001370731.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001357660.1",
          "strand": false,
          "transcript": "NM_001370731.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2705,
          "cdna_start": 345,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "NM_001370732.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001357661.1",
          "strand": false,
          "transcript": "NM_001370732.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3038,
          "cdna_start": 678,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_003563.3",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_003554.1",
          "strand": false,
          "transcript": "NM_003563.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2965,
          "cdna_start": 607,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000347630.6",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000240327.2",
          "strand": false,
          "transcript": "ENST00000347630.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1932,
          "cdna_start": 891,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000503676.5",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000420908.1",
          "strand": false,
          "transcript": "ENST00000503676.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1860,
          "cdna_start": 606,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000509079.6",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000426986.2",
          "strand": false,
          "transcript": "ENST00000509079.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2414,
          "cdna_start": 717,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000514121.6",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000424119.2",
          "strand": false,
          "transcript": "ENST00000514121.6",
          "transcript_support_level": 4
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2480,
          "cdna_start": 763,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000665825.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000499562.1",
          "strand": false,
          "transcript": "ENST00000665825.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2003,
          "cdna_start": 784,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000854669.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000524728.1",
          "strand": false,
          "transcript": "ENST00000854669.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1886,
          "cdna_start": 644,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000854670.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000524729.1",
          "strand": false,
          "transcript": "ENST00000854670.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "D",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "Y",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1797,
          "cdna_start": 541,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000854671.1",
          "gene_hgnc_id": 11254,
          "gene_symbol": "SPOP",
          "hgvs_c": "c.259T>G",
          "hgvs_p": "p.Tyr87Asp",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000524730.1",
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      "revel_score": 0.808,
      "splice_prediction_selected": "Benign",
      "splice_score_selected": 0,
      "splice_source_selected": "max_spliceai",
      "spliceai_max_prediction": "Benign",
      "spliceai_max_score": 0,
      "transcript": "NM_003563.3"
    }
  ]
}
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