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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-50550731-A-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=50550731&ref=A&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 13,
          "criteria": [
            "BP4_Strong",
            "BP7",
            "BA1"
          ],
          "effects": [
            "synonymous_variant"
          ],
          "gene_symbol": "SPATA20",
          "hgnc_id": 26125,
          "hgvs_c": "c.1197A>G",
          "hgvs_p": "p.Glu399Glu",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": -13,
          "transcript": "NM_022827.4",
          "verdict": "Benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP7,BA1",
      "acmg_score": -13,
      "allele_count_reference_population": 413661,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "G",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.52,
      "chr": "17",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.5199999809265137,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 802,
          "aa_ref": "E",
          "aa_start": 399,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2634,
          "cdna_start": 1232,
          "cds_end": null,
          "cds_length": 2409,
          "cds_start": 1197,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "NM_022827.4",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1197A>G",
          "hgvs_p": "p.Glu399Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000006658.11",
          "protein_coding": true,
          "protein_id": "NP_073738.2",
          "strand": true,
          "transcript": "NM_022827.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 802,
          "aa_ref": "E",
          "aa_start": 399,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2634,
          "cdna_start": 1232,
          "cds_end": null,
          "cds_length": 2409,
          "cds_start": 1197,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000006658.11",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1197A>G",
          "hgvs_p": "p.Glu399Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_022827.4",
          "protein_coding": true,
          "protein_id": "ENSP00000006658.6",
          "strand": true,
          "transcript": "ENST00000006658.11",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 786,
          "aa_ref": "E",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2634,
          "cdna_start": 1232,
          "cds_end": null,
          "cds_length": 2361,
          "cds_start": 1149,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 16,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000356488.8",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1149A>G",
          "hgvs_p": "p.Glu383Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000348878.4",
          "strand": true,
          "transcript": "ENST00000356488.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2734,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000503127.5",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "n.*1120A>G",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000426228.1",
          "strand": true,
          "transcript": "ENST00000503127.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2669,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 16,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000511937.5",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "n.1149A>G",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000489476.1",
          "strand": true,
          "transcript": "ENST00000511937.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1706,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 11,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000635113.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "n.1161A>G",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000635113.1",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2734,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000503127.5",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "n.*1120A>G",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000426228.1",
          "strand": true,
          "transcript": "ENST00000503127.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 824,
          "aa_ref": "E",
          "aa_start": 421,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2691,
          "cdna_start": 1289,
          "cds_end": null,
          "cds_length": 2475,
          "cds_start": 1263,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000860314.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1263A>G",
          "hgvs_p": "p.Glu421Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000530373.1",
          "strand": true,
          "transcript": "ENST00000860314.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 810,
          "aa_ref": "E",
          "aa_start": 399,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2647,
          "cdna_start": 1223,
          "cds_end": null,
          "cds_length": 2433,
          "cds_start": 1197,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 18,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000953008.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1197A>G",
          "hgvs_p": "p.Glu399Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000623067.1",
          "strand": true,
          "transcript": "ENST00000953008.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 809,
          "aa_ref": "E",
          "aa_start": 406,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2636,
          "cdna_start": 1234,
          "cds_end": null,
          "cds_length": 2430,
          "cds_start": 1218,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000860317.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1218A>G",
          "hgvs_p": "p.Glu406Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000530376.1",
          "strand": true,
          "transcript": "ENST00000860317.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 800,
          "aa_ref": "E",
          "aa_start": 397,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2628,
          "cdna_start": 1226,
          "cds_end": null,
          "cds_length": 2403,
          "cds_start": 1191,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000860311.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1191A>G",
          "hgvs_p": "p.Glu397Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000530370.1",
          "strand": true,
          "transcript": "ENST00000860311.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 799,
          "aa_ref": "E",
          "aa_start": 399,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2625,
          "cdna_start": 1232,
          "cds_end": null,
          "cds_length": 2400,
          "cds_start": 1197,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000860313.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1197A>G",
          "hgvs_p": "p.Glu399Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000530372.1",
          "strand": true,
          "transcript": "ENST00000860313.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 799,
          "aa_ref": "E",
          "aa_start": 396,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2613,
          "cdna_start": 1211,
          "cds_end": null,
          "cds_length": 2400,
          "cds_start": 1188,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000860315.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1188A>G",
          "hgvs_p": "p.Glu396Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000530374.1",
          "strand": true,
          "transcript": "ENST00000860315.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 799,
          "aa_ref": "E",
          "aa_start": 396,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2594,
          "cdna_start": 1192,
          "cds_end": null,
          "cds_length": 2400,
          "cds_start": 1188,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000860320.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1188A>G",
          "hgvs_p": "p.Glu396Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000530379.1",
          "strand": true,
          "transcript": "ENST00000860320.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 797,
          "aa_ref": "E",
          "aa_start": 399,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2597,
          "cdna_start": 1213,
          "cds_end": null,
          "cds_length": 2394,
          "cds_start": 1197,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 17,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000912606.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1197A>G",
          "hgvs_p": "p.Glu399Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000582665.1",
          "strand": true,
          "transcript": "ENST00000912606.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 790,
          "aa_ref": "E",
          "aa_start": 390,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2614,
          "cdna_start": 1223,
          "cds_end": null,
          "cds_length": 2373,
          "cds_start": 1170,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 16,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000860310.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1170A>G",
          "hgvs_p": "p.Glu390Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000530369.1",
          "strand": true,
          "transcript": "ENST00000860310.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 786,
          "aa_ref": "E",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2586,
          "cdna_start": 1184,
          "cds_end": null,
          "cds_length": 2361,
          "cds_start": 1149,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 16,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "NM_001258372.2",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1149A>G",
          "hgvs_p": "p.Glu383Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001245301.1",
          "strand": true,
          "transcript": "NM_001258372.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 786,
          "aa_ref": "E",
          "aa_start": 383,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2587,
          "cdna_start": 1185,
          "cds_end": null,
          "cds_length": 2361,
          "cds_start": 1149,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 16,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000634597.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1149A>G",
          "hgvs_p": "p.Glu383Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000489591.1",
          "strand": true,
          "transcript": "ENST00000634597.1",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 784,
          "aa_ref": "E",
          "aa_start": 381,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2565,
          "cdna_start": 1165,
          "cds_end": null,
          "cds_length": 2355,
          "cds_start": 1143,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 16,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000860316.1",
          "gene_hgnc_id": 26125,
          "gene_symbol": "SPATA20",
          "hgvs_c": "c.1143A>G",
          "hgvs_p": "p.Glu381Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
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}
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