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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-58720792-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=58720792&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"message": null,
"variants": [
{
"acmg_by_gene": [
{
"benign_score": 1,
"criteria": [
"PM1",
"PM2",
"BP4"
],
"effects": [
"missense_variant"
],
"gene_symbol": "RAD51C",
"hgnc_id": 9820,
"hgvs_c": "c.884C>A",
"hgvs_p": "p.Ala295Asp",
"inheritance_mode": "AR,AD",
"pathogenic_score": 4,
"score": 3,
"transcript": "NM_058216.3",
"verdict": "Uncertain_significance"
}
],
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "PM1,PM2,BP4",
"acmg_score": 3,
"allele_count_reference_population": 0,
"alphamissense_prediction": null,
"alphamissense_score": 0.5936,
"alt": "A",
"apogee2_prediction": null,
"apogee2_score": null,
"bayesdelnoaf_prediction": "Benign",
"bayesdelnoaf_score": -0.33,
"chr": "17",
"clinvar_classification": "Uncertain significance",
"clinvar_disease": "Fanconi anemia complementation group O,Hereditary cancer-predisposing syndrome",
"clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
"clinvar_submissions_summary": "US:2",
"computational_prediction_selected": "Benign",
"computational_score_selected": 0.3572089374065399,
"computational_source_selected": "MetaRNN",
"consequences": [
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 376,
"aa_ref": "A",
"aa_start": 295,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2562,
"cdna_start": 926,
"cds_end": null,
"cds_length": 1131,
"cds_start": 884,
"consequences": [
"missense_variant"
],
"exon_count": 9,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "NM_058216.3",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.884C>A",
"hgvs_p": "p.Ala295Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "ENST00000337432.9",
"protein_coding": true,
"protein_id": "NP_478123.1",
"strand": true,
"transcript": "NM_058216.3",
"transcript_support_level": null
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 376,
"aa_ref": "A",
"aa_start": 295,
"biotype": "protein_coding",
"canonical": true,
"cdna_end": null,
"cdna_length": 2562,
"cdna_start": 926,
"cds_end": null,
"cds_length": 1131,
"cds_start": 884,
"consequences": [
"missense_variant"
],
"exon_count": 9,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "ENST00000337432.9",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.884C>A",
"hgvs_p": "p.Ala295Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "NM_058216.3",
"protein_coding": true,
"protein_id": "ENSP00000336701.4",
"strand": true,
"transcript": "ENST00000337432.9",
"transcript_support_level": 1
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": null,
"aa_ref": null,
"aa_start": null,
"biotype": "nonsense_mediated_decay",
"canonical": false,
"cdna_end": null,
"cdna_length": 1098,
"cdna_start": null,
"cds_end": null,
"cds_length": null,
"cds_start": null,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_count": 8,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000482007.5",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "n.*312C>A",
"hgvs_p": null,
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": false,
"protein_id": "ENSP00000433332.1",
"strand": true,
"transcript": "ENST00000482007.5",
"transcript_support_level": 1
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": null,
"aa_ref": null,
"aa_start": null,
"biotype": "nonsense_mediated_decay",
"canonical": false,
"cdna_end": null,
"cdna_length": 1098,
"cdna_start": null,
"cds_end": null,
"cds_length": null,
"cds_start": null,
"consequences": [
"3_prime_UTR_variant"
],
"exon_count": 8,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000482007.5",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "n.*312C>A",
"hgvs_p": null,
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": false,
"protein_id": "ENSP00000433332.1",
"strand": true,
"transcript": "ENST00000482007.5",
"transcript_support_level": 1
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 410,
"aa_ref": "A",
"aa_start": 329,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1406,
"cdna_start": 1054,
"cds_end": null,
"cds_length": 1233,
"cds_start": 986,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000930423.1",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.986C>A",
"hgvs_p": "p.Ala329Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000600482.1",
"strand": true,
"transcript": "ENST00000930423.1",
"transcript_support_level": null
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 392,
"aa_ref": "A",
"aa_start": 311,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1355,
"cdna_start": 1003,
"cds_end": null,
"cds_length": 1179,
"cds_start": 932,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 7,
"exon_rank_end": null,
"feature": "ENST00000875229.1",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.932C>A",
"hgvs_p": "p.Ala311Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000545288.1",
"strand": true,
"transcript": "ENST00000875229.1",
"transcript_support_level": null
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 346,
"aa_ref": "A",
"aa_start": 295,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1319,
"cdna_start": 955,
"cds_end": null,
"cds_length": 1041,
"cds_start": 884,
"consequences": [
"missense_variant"
],
"exon_count": 8,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "ENST00000583539.5",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.884C>A",
"hgvs_p": "p.Ala295Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000463121.1",
"strand": true,
"transcript": "ENST00000583539.5",
"transcript_support_level": 2
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 339,
"aa_ref": "A",
"aa_start": 258,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1152,
"cdna_start": 804,
"cds_end": null,
"cds_length": 1020,
"cds_start": 773,
"consequences": [
"missense_variant"
],
"exon_count": 9,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "ENST00000948099.1",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.773C>A",
"hgvs_p": "p.Ala258Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000618158.1",
"strand": true,
"transcript": "ENST00000948099.1",
"transcript_support_level": null
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 305,
"aa_ref": "A",
"aa_start": 295,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1375,
"cdna_start": 926,
"cds_end": null,
"cds_length": 918,
"cds_start": 884,
"consequences": [
"missense_variant"
],
"exon_count": 7,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "ENST00000697690.1",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.884C>A",
"hgvs_p": "p.Ala295Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000513399.1",
"strand": true,
"transcript": "ENST00000697690.1",
"transcript_support_level": null
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 286,
"aa_ref": "A",
"aa_start": 178,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1400,
"cdna_start": 776,
"cds_end": null,
"cds_length": 861,
"cds_start": 533,
"consequences": [
"missense_variant"
],
"exon_count": 10,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "ENST00000697686.1",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.533C>A",
"hgvs_p": "p.Ala178Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000513397.1",
"strand": true,
"transcript": "ENST00000697686.1",
"transcript_support_level": null
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 259,
"aa_ref": "A",
"aa_start": 178,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1618,
"cdna_start": 976,
"cds_end": null,
"cds_length": 780,
"cds_start": 533,
"consequences": [
"missense_variant"
],
"exon_count": 9,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "ENST00000697694.1",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.533C>A",
"hgvs_p": "p.Ala178Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000513402.1",
"strand": true,
"transcript": "ENST00000697694.1",
"transcript_support_level": null
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 256,
"aa_ref": "A",
"aa_start": 174,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 779,
"cdna_start": 522,
"cds_end": null,
"cds_length": 771,
"cds_start": 521,
"consequences": [
"missense_variant"
],
"exon_count": 8,
"exon_rank": 5,
"exon_rank_end": null,
"feature": "ENST00000413590.5",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.521C>A",
"hgvs_p": "p.Ala174Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000401741.1",
"strand": true,
"transcript": "ENST00000413590.5",
"transcript_support_level": 2
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 229,
"aa_ref": "A",
"aa_start": 178,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2761,
"cdna_start": 852,
"cds_end": null,
"cds_length": 690,
"cds_start": 533,
"consequences": [
"missense_variant"
],
"exon_count": 8,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "ENST00000461271.6",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.533C>A",
"hgvs_p": "p.Ala178Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000464056.2",
"strand": true,
"transcript": "ENST00000461271.6",
"transcript_support_level": 5
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 107,
"aa_ref": "A",
"aa_start": 60,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 474,
"cdna_start": 179,
"cds_end": null,
"cds_length": 324,
"cds_start": 179,
"consequences": [
"missense_variant"
],
"exon_count": 4,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000584804.1",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.179C>A",
"hgvs_p": "p.Ala60Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000463658.1",
"strand": true,
"transcript": "ENST00000584804.1",
"transcript_support_level": 3
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 377,
"aa_ref": "A",
"aa_start": 295,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2565,
"cdna_start": 926,
"cds_end": null,
"cds_length": 1134,
"cds_start": 884,
"consequences": [
"missense_variant"
],
"exon_count": 9,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "XM_006722001.5",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.884C>A",
"hgvs_p": "p.Ala295Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_006722064.1",
"strand": true,
"transcript": "XM_006722001.5",
"transcript_support_level": null
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 342,
"aa_ref": "A",
"aa_start": 295,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2501,
"cdna_start": 926,
"cds_end": null,
"cds_length": 1029,
"cds_start": 884,
"consequences": [
"missense_variant"
],
"exon_count": 8,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "XM_006722002.5",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.884C>A",
"hgvs_p": "p.Ala295Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_006722065.1",
"strand": true,
"transcript": "XM_006722002.5",
"transcript_support_level": null
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 260,
"aa_ref": "A",
"aa_start": 178,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2491,
"cdna_start": 852,
"cds_end": null,
"cds_length": 783,
"cds_start": 533,
"consequences": [
"missense_variant"
],
"exon_count": 9,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "XM_006722004.4",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.533C>A",
"hgvs_p": "p.Ala178Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_006722067.1",
"strand": true,
"transcript": "XM_006722004.4",
"transcript_support_level": null
},
{
"aa_alt": "D",
"aa_end": null,
"aa_length": 260,
"aa_ref": "A",
"aa_start": 178,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 2541,
"cdna_start": 902,
"cds_end": null,
"cds_length": 783,
"cds_start": 533,
"consequences": [
"missense_variant"
],
"exon_count": 9,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "XM_011525094.3",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.533C>A",
"hgvs_p": "p.Ala178Asp",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "XP_011523396.1",
"strand": true,
"transcript": "XM_011525094.3",
"transcript_support_level": null
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": 313,
"aa_ref": null,
"aa_start": null,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1115,
"cdna_start": null,
"cds_end": null,
"cds_length": 942,
"cds_start": null,
"consequences": [
"intron_variant"
],
"exon_count": 6,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000930424.1",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "c.837+10802C>A",
"hgvs_p": null,
"intron_rank": 5,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000600483.1",
"strand": true,
"transcript": "ENST00000930424.1",
"transcript_support_level": null
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": null,
"aa_ref": null,
"aa_start": null,
"biotype": "nonsense_mediated_decay",
"canonical": false,
"cdna_end": null,
"cdna_length": 1253,
"cdna_start": null,
"cds_end": null,
"cds_length": null,
"cds_start": null,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_count": 9,
"exon_rank": 6,
"exon_rank_end": null,
"feature": "ENST00000487525.5",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "n.*457C>A",
"hgvs_p": null,
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": false,
"protein_id": "ENSP00000431637.1",
"strand": true,
"transcript": "ENST00000487525.5",
"transcript_support_level": 5
},
{
"aa_alt": null,
"aa_end": null,
"aa_length": null,
"aa_ref": null,
"aa_start": null,
"biotype": "retained_intron",
"canonical": false,
"cdna_end": null,
"cdna_length": 464,
"cdna_start": null,
"cds_end": null,
"cds_length": null,
"cds_start": null,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_count": 3,
"exon_rank": 2,
"exon_rank_end": null,
"feature": "ENST00000578151.1",
"gene_hgnc_id": 9820,
"gene_symbol": "RAD51C",
"hgvs_c": "n.219C>A",
"hgvs_p": null,
"intron_rank": null,
"intron_rank_end": null,
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}