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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-59912499-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=59912499&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 59912499,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000225577.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.192-185G>C",
"hgvs_p": null,
"transcript": "NM_003161.4",
"protein_id": "NP_003152.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 525,
"cds_start": -4,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5428,
"mane_select": "ENST00000225577.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.192-185G>C",
"hgvs_p": null,
"transcript": "ENST00000225577.9",
"protein_id": "ENSP00000225577.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 525,
"cds_start": -4,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5428,
"mane_select": "NM_003161.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.192-185G>C",
"hgvs_p": null,
"transcript": "ENST00000406116.7",
"protein_id": "ENSP00000384335.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 451,
"cds_start": -4,
"cds_end": null,
"cds_length": 1356,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1982,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.192-185G>C",
"hgvs_p": null,
"transcript": "NM_001272042.2",
"protein_id": "NP_001258971.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5359,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.123-185G>C",
"hgvs_p": null,
"transcript": "NM_001272060.2",
"protein_id": "NP_001258989.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5428,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.192-185G>C",
"hgvs_p": null,
"transcript": "ENST00000443572.6",
"protein_id": "ENSP00000441993.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1913,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.192-185G>C",
"hgvs_p": null,
"transcript": "NM_001369669.1",
"protein_id": "NP_001356598.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 489,
"cds_start": -4,
"cds_end": null,
"cds_length": 1470,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5320,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.33-185G>C",
"hgvs_p": null,
"transcript": "NM_001272044.2",
"protein_id": "NP_001258973.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 472,
"cds_start": -4,
"cds_end": null,
"cds_length": 1419,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5557,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.33-185G>C",
"hgvs_p": null,
"transcript": "ENST00000393021.7",
"protein_id": "ENSP00000376744.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 472,
"cds_start": -4,
"cds_end": null,
"cds_length": 1419,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5479,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.192-185G>C",
"hgvs_p": null,
"transcript": "NM_001272043.2",
"protein_id": "NP_001258972.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 451,
"cds_start": -4,
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"cds_length": 1356,
"cdna_start": null,
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"cdna_length": 4238,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.33-185G>C",
"hgvs_p": null,
"transcript": "NM_001369670.1",
"protein_id": "NP_001356599.1",
"transcript_support_level": null,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 1,
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"gene_symbol": "RPS6KB1",
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"hgvs_c": "c.142-13936G>C",
"hgvs_p": null,
"transcript": "NM_001369671.1",
"protein_id": "NP_001356600.1",
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"cds_start": -4,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 3,
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"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.33-185G>C",
"hgvs_p": null,
"transcript": "NM_001369672.1",
"protein_id": "NP_001356601.1",
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},
{
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"strand": true,
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],
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"intron_rank": 2,
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"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.192-185G>C",
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"transcript": "NM_001369674.1",
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},
{
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],
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"gene_symbol": "RPS6KB1",
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"hgvs_c": "c.192-185G>C",
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"transcript": "NM_001369675.1",
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},
{
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],
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"gene_symbol": "RPS6KB1",
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"transcript": "NM_001369676.1",
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},
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],
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"gene_symbol": "RPS6KB1",
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"hgvs_c": "c.192-185G>C",
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"transcript": "NM_001369677.1",
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},
{
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],
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"intron_rank": 2,
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"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.192-185G>C",
"hgvs_p": null,
"transcript": "NM_001369678.1",
"protein_id": "NP_001356607.1",
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},
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],
"exon_rank": null,
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"gene_symbol": "RPS6KB1",
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"hgvs_c": "c.192-185G>C",
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],
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"gene_symbol": "RPS6KB1",
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},
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],
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"hgvs_c": "c.33-185G>C",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 2,
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"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "n.192-185G>C",
"hgvs_p": null,
"transcript": "ENST00000472940.5",
"protein_id": "ENSP00000468058.1",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 2,
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"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "n.251-185G>C",
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"transcript": "ENST00000477179.5",
"protein_id": null,
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}
],
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}