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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-59936844-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=59936844&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 59936844,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000225577.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.1119+303A>G",
"hgvs_p": null,
"transcript": "NM_003161.4",
"protein_id": "NP_003152.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 525,
"cds_start": -4,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5428,
"mane_select": "ENST00000225577.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.1119+303A>G",
"hgvs_p": null,
"transcript": "ENST00000225577.9",
"protein_id": "ENSP00000225577.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 525,
"cds_start": -4,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5428,
"mane_select": "NM_003161.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.1119+303A>G",
"hgvs_p": null,
"transcript": "ENST00000406116.7",
"protein_id": "ENSP00000384335.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 451,
"cds_start": -4,
"cds_end": null,
"cds_length": 1356,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1982,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.1050+303A>G",
"hgvs_p": null,
"transcript": "NM_001272042.2",
"protein_id": "NP_001258971.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5359,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.1050+303A>G",
"hgvs_p": null,
"transcript": "NM_001272060.2",
"protein_id": "NP_001258989.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5428,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.1050+303A>G",
"hgvs_p": null,
"transcript": "ENST00000443572.6",
"protein_id": "ENSP00000441993.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1913,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.1119+303A>G",
"hgvs_p": null,
"transcript": "NM_001369669.1",
"protein_id": "NP_001356598.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 489,
"cds_start": -4,
"cds_end": null,
"cds_length": 1470,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5320,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.960+303A>G",
"hgvs_p": null,
"transcript": "NM_001272044.2",
"protein_id": "NP_001258973.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 472,
"cds_start": -4,
"cds_end": null,
"cds_length": 1419,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5557,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.960+303A>G",
"hgvs_p": null,
"transcript": "ENST00000393021.7",
"protein_id": "ENSP00000376744.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 472,
"cds_start": -4,
"cds_end": null,
"cds_length": 1419,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5479,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.1119+303A>G",
"hgvs_p": null,
"transcript": "NM_001272043.2",
"protein_id": "NP_001258972.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 451,
"cds_start": -4,
"cds_end": null,
"cds_length": 1356,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4238,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.897+303A>G",
"hgvs_p": null,
"transcript": "NM_001369670.1",
"protein_id": "NP_001356599.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 451,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 5364,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.879+303A>G",
"hgvs_p": null,
"transcript": "NM_001369671.1",
"protein_id": "NP_001356600.1",
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"aa_start": null,
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"aa_length": 445,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.960+303A>G",
"hgvs_p": null,
"transcript": "NM_001369672.1",
"protein_id": "NP_001356601.1",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.*712+303A>G",
"hgvs_p": null,
"transcript": "NM_001369674.1",
"protein_id": "NP_001356603.1",
"transcript_support_level": null,
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},
{
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"strand": true,
"consequences": [
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],
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"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.*712+303A>G",
"hgvs_p": null,
"transcript": "NM_001369675.1",
"protein_id": "NP_001356604.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.*473+303A>G",
"hgvs_p": null,
"transcript": "NM_001369676.1",
"protein_id": "NP_001356605.1",
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},
{
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],
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"intron_rank": 14,
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"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.*823+303A>G",
"hgvs_p": null,
"transcript": "NM_001369677.1",
"protein_id": "NP_001356606.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.*570+303A>G",
"hgvs_p": null,
"transcript": "NM_001369678.1",
"protein_id": "NP_001356607.1",
"transcript_support_level": null,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.*827+303A>G",
"hgvs_p": null,
"transcript": "NM_001369679.1",
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},
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],
"exon_rank": null,
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"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "c.*570+303A>G",
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"transcript": "NM_001369673.1",
"protein_id": "NP_001356602.1",
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},
{
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"protein_coding": false,
"strand": true,
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],
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"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "n.*1154+303A>G",
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"transcript": "ENST00000472940.5",
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},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "n.1035+303A>G",
"hgvs_p": null,
"transcript": "NR_161455.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "RPS6KB1",
"gene_hgnc_id": 10436,
"hgvs_c": "n.1186+303A>G",
"hgvs_p": null,
"transcript": "NR_161456.1",
"protein_id": null,
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"mane_select": null,
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}