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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-63698922-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=63698922&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 63698922,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_030576.4",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "NM_030576.4",
"protein_id": "NP_085053.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 245,
"cdna_end": null,
"cdna_length": 3192,
"mane_select": "ENST00000259006.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_030576.4"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000259006.8",
"protein_id": "ENSP00000259006.3",
"transcript_support_level": 1,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 245,
"cdna_end": null,
"cdna_length": 3192,
"mane_select": "NM_030576.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000259006.8"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000578402.5",
"protein_id": "ENSP00000462707.1",
"transcript_support_level": 1,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 515,
"cdna_end": null,
"cdna_length": 1534,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000578402.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "n.1000C>T",
"hgvs_p": null,
"transcript": "ENST00000578067.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2019,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000578067.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "n.254C>T",
"hgvs_p": null,
"transcript": "ENST00000579329.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 920,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000579329.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000578061.5",
"protein_id": "ENSP00000464003.1",
"transcript_support_level": 2,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 210,
"cdna_end": null,
"cdna_length": 756,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000578061.5"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000851314.1",
"protein_id": "ENSP00000521373.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 931,
"cdna_end": null,
"cdna_length": 3883,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851314.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000851315.1",
"protein_id": "ENSP00000521374.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 342,
"cdna_end": null,
"cdna_length": 1368,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851315.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000851316.1",
"protein_id": "ENSP00000521375.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 479,
"cdna_end": null,
"cdna_length": 1507,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851316.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000851317.1",
"protein_id": "ENSP00000521376.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 328,
"cdna_end": null,
"cdna_length": 1357,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851317.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000851318.1",
"protein_id": "ENSP00000521377.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 319,
"cdna_end": null,
"cdna_length": 1348,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851318.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000851319.1",
"protein_id": "ENSP00000521378.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 265,
"cdna_end": null,
"cdna_length": 1274,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851319.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000851322.1",
"protein_id": "ENSP00000521381.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 208,
"cdna_end": null,
"cdna_length": 1235,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851322.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000923159.1",
"protein_id": "ENSP00000593218.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 394,
"cdna_end": null,
"cdna_length": 1424,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923159.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000923160.1",
"protein_id": "ENSP00000593219.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 225,
"cdna_end": null,
"cdna_length": 1243,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923160.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000923161.1",
"protein_id": "ENSP00000593220.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 249,
"cdna_end": null,
"cdna_length": 1277,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000923161.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000953954.1",
"protein_id": "ENSP00000624013.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 369,
"cdna_end": null,
"cdna_length": 1399,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953954.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000953955.1",
"protein_id": "ENSP00000624014.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 423,
"cdna_end": null,
"cdna_length": 1450,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000953955.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "ENST00000584645.1",
"protein_id": "ENSP00000463805.1",
"transcript_support_level": 3,
"aa_start": 34,
"aa_end": null,
"aa_length": 108,
"cds_start": 101,
"cds_end": null,
"cds_length": 327,
"cdna_start": 340,
"cdna_end": null,
"cdna_length": 566,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000584645.1"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "XM_005257703.2",
"protein_id": "XP_005257760.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 474,
"cdna_end": null,
"cdna_length": 3421,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005257703.2"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "XM_005257705.5",
"protein_id": "XP_005257762.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 323,
"cdna_end": null,
"cdna_length": 3270,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005257705.5"
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LIMD2",
"gene_hgnc_id": 28142,
"hgvs_c": "c.101C>T",
"hgvs_p": "p.Ala34Val",
"transcript": "XM_006722124.3",
"protein_id": "XP_006722187.1",
"transcript_support_level": null,
"aa_start": 34,
"aa_end": null,
"aa_length": 127,
"cds_start": 101,
"cds_end": null,
"cds_length": 384,
"cdna_start": 311,
"cdna_end": null,
"cdna_length": 3258,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006722124.3"
},
{
"aa_ref": "A",
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"canonical": false,
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{
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}
],
"message": null
}