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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-64356203-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=64356203&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 64356203,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_000442.5",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "NM_000442.5",
"protein_id": "NP_000433.4",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 738,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2217,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000563924.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000442.5"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000563924.6",
"protein_id": "ENSP00000457421.1",
"transcript_support_level": 1,
"aa_start": 563,
"aa_end": null,
"aa_length": 738,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2217,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000442.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000563924.6"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904885.1",
"protein_id": "ENSP00000574944.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 770,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2313,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904885.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904891.1",
"protein_id": "ENSP00000574950.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 770,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2313,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904891.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904892.1",
"protein_id": "ENSP00000574951.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 769,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2310,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904892.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1685G>A",
"hgvs_p": "p.Ser562Asn",
"transcript": "ENST00000951550.1",
"protein_id": "ENSP00000621609.1",
"transcript_support_level": null,
"aa_start": 562,
"aa_end": null,
"aa_length": 768,
"cds_start": 1685,
"cds_end": null,
"cds_length": 2307,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951550.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000951545.1",
"protein_id": "ENSP00000621604.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 751,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2256,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951545.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000951548.1",
"protein_id": "ENSP00000621607.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 751,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2256,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951548.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904882.1",
"protein_id": "ENSP00000574941.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 739,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2220,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904882.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904873.1",
"protein_id": "ENSP00000574932.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 738,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2217,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904873.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904874.1",
"protein_id": "ENSP00000574933.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 738,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2217,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904874.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904875.1",
"protein_id": "ENSP00000574934.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 738,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2217,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904875.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904889.1",
"protein_id": "ENSP00000574948.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 738,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2217,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904889.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1685G>A",
"hgvs_p": "p.Ser562Asn",
"transcript": "ENST00000951542.1",
"protein_id": "ENSP00000621601.1",
"transcript_support_level": null,
"aa_start": 562,
"aa_end": null,
"aa_length": 737,
"cds_start": 1685,
"cds_end": null,
"cds_length": 2214,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951542.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1661G>A",
"hgvs_p": "p.Ser554Asn",
"transcript": "ENST00000951549.1",
"protein_id": "ENSP00000621608.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 729,
"cds_start": 1661,
"cds_end": null,
"cds_length": 2190,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951549.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1637G>A",
"hgvs_p": "p.Ser546Asn",
"transcript": "ENST00000904877.1",
"protein_id": "ENSP00000574936.1",
"transcript_support_level": null,
"aa_start": 546,
"aa_end": null,
"aa_length": 721,
"cds_start": 1637,
"cds_end": null,
"cds_length": 2166,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904877.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904878.1",
"protein_id": "ENSP00000574937.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 720,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904878.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904876.1",
"protein_id": "ENSP00000574935.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 719,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2160,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904876.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904884.1",
"protein_id": "ENSP00000574943.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 719,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2160,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904884.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904879.1",
"protein_id": "ENSP00000574938.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 717,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2154,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904879.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1688G>A",
"hgvs_p": "p.Ser563Asn",
"transcript": "ENST00000904890.1",
"protein_id": "ENSP00000574949.1",
"transcript_support_level": null,
"aa_start": 563,
"aa_end": null,
"aa_length": 717,
"cds_start": 1688,
"cds_end": null,
"cds_length": 2154,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000904890.1"
},
{
"aa_ref": "S",
"aa_alt": "N",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PECAM1",
"gene_hgnc_id": 8823,
"hgvs_c": "c.1604G>A",
"hgvs_p": "p.Ser535Asn",
"transcript": "ENST00000951546.1",
"protein_id": "ENSP00000621605.1",
"transcript_support_level": null,
"aa_start": 535,
"aa_end": null,
"aa_length": 710,
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