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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-66220681-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=66220681&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "17",
      "pos": 66220681,
      "ref": "T",
      "alt": "C",
      "effect": "synonymous_variant",
      "transcript": "NM_000042.3",
      "consequences": [
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.477A>G",
          "hgvs_p": "p.Ser159Ser",
          "transcript": "NM_000042.3",
          "protein_id": "NP_000033.2",
          "transcript_support_level": null,
          "aa_start": 159,
          "aa_end": null,
          "aa_length": 345,
          "cds_start": 477,
          "cds_end": null,
          "cds_length": 1038,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000205948.11",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_000042.3"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.477A>G",
          "hgvs_p": "p.Ser159Ser",
          "transcript": "ENST00000205948.11",
          "protein_id": "ENSP00000205948.6",
          "transcript_support_level": 1,
          "aa_start": 159,
          "aa_end": null,
          "aa_length": 345,
          "cds_start": 477,
          "cds_end": null,
          "cds_length": 1038,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_000042.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000205948.11"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.477A>G",
          "hgvs_p": "p.Ser159Ser",
          "transcript": "ENST00000879124.1",
          "protein_id": "ENSP00000549183.1",
          "transcript_support_level": null,
          "aa_start": 159,
          "aa_end": null,
          "aa_length": 345,
          "cds_start": 477,
          "cds_end": null,
          "cds_length": 1038,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879124.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.477A>G",
          "hgvs_p": "p.Ser159Ser",
          "transcript": "ENST00000879112.1",
          "protein_id": "ENSP00000549171.1",
          "transcript_support_level": null,
          "aa_start": 159,
          "aa_end": null,
          "aa_length": 344,
          "cds_start": 477,
          "cds_end": null,
          "cds_length": 1035,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879112.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.471A>G",
          "hgvs_p": "p.Ser157Ser",
          "transcript": "ENST00000879110.1",
          "protein_id": "ENSP00000549169.1",
          "transcript_support_level": null,
          "aa_start": 157,
          "aa_end": null,
          "aa_length": 343,
          "cds_start": 471,
          "cds_end": null,
          "cds_length": 1032,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879110.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.462A>G",
          "hgvs_p": "p.Ser154Ser",
          "transcript": "ENST00000879126.1",
          "protein_id": "ENSP00000549185.1",
          "transcript_support_level": null,
          "aa_start": 154,
          "aa_end": null,
          "aa_length": 340,
          "cds_start": 462,
          "cds_end": null,
          "cds_length": 1023,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879126.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.447A>G",
          "hgvs_p": "p.Ser149Ser",
          "transcript": "ENST00000879125.1",
          "protein_id": "ENSP00000549184.1",
          "transcript_support_level": null,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 335,
          "cds_start": 447,
          "cds_end": null,
          "cds_length": 1008,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879125.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.441A>G",
          "hgvs_p": "p.Ser147Ser",
          "transcript": "ENST00000879109.1",
          "protein_id": "ENSP00000549168.1",
          "transcript_support_level": null,
          "aa_start": 147,
          "aa_end": null,
          "aa_length": 333,
          "cds_start": 441,
          "cds_end": null,
          "cds_length": 1002,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879109.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.435A>G",
          "hgvs_p": "p.Ser145Ser",
          "transcript": "ENST00000879127.1",
          "protein_id": "ENSP00000549186.1",
          "transcript_support_level": null,
          "aa_start": 145,
          "aa_end": null,
          "aa_length": 331,
          "cds_start": 435,
          "cds_end": null,
          "cds_length": 996,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879127.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.384A>G",
          "hgvs_p": "p.Ser128Ser",
          "transcript": "ENST00000879117.1",
          "protein_id": "ENSP00000549176.1",
          "transcript_support_level": null,
          "aa_start": 128,
          "aa_end": null,
          "aa_length": 314,
          "cds_start": 384,
          "cds_end": null,
          "cds_length": 945,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879117.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.303A>G",
          "hgvs_p": "p.Ser101Ser",
          "transcript": "ENST00000879119.1",
          "protein_id": "ENSP00000549178.1",
          "transcript_support_level": null,
          "aa_start": 101,
          "aa_end": null,
          "aa_length": 287,
          "cds_start": 303,
          "cds_end": null,
          "cds_length": 864,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879119.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.300A>G",
          "hgvs_p": "p.Ser100Ser",
          "transcript": "ENST00000879111.1",
          "protein_id": "ENSP00000549170.1",
          "transcript_support_level": null,
          "aa_start": 100,
          "aa_end": null,
          "aa_length": 286,
          "cds_start": 300,
          "cds_end": null,
          "cds_length": 861,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879111.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.477A>G",
          "hgvs_p": "p.Ser159Ser",
          "transcript": "ENST00000879115.1",
          "protein_id": "ENSP00000549174.1",
          "transcript_support_level": null,
          "aa_start": 159,
          "aa_end": null,
          "aa_length": 285,
          "cds_start": 477,
          "cds_end": null,
          "cds_length": 858,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879115.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.126A>G",
          "hgvs_p": "p.Ser42Ser",
          "transcript": "ENST00000879116.1",
          "protein_id": "ENSP00000549175.1",
          "transcript_support_level": null,
          "aa_start": 42,
          "aa_end": null,
          "aa_length": 228,
          "cds_start": 126,
          "cds_end": null,
          "cds_length": 687,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879116.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.477A>G",
          "hgvs_p": "p.Ser159Ser",
          "transcript": "ENST00000879114.1",
          "protein_id": "ENSP00000549173.1",
          "transcript_support_level": null,
          "aa_start": 159,
          "aa_end": null,
          "aa_length": 219,
          "cds_start": 477,
          "cds_end": null,
          "cds_length": 660,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879114.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.297A>G",
          "hgvs_p": "p.Ser99Ser",
          "transcript": "ENST00000581797.5",
          "protein_id": "ENSP00000463553.1",
          "transcript_support_level": 3,
          "aa_start": 99,
          "aa_end": null,
          "aa_length": 199,
          "cds_start": 297,
          "cds_end": null,
          "cds_length": 601,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000581797.5"
        },
        {
          "aa_ref": "S",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.477A>G",
          "hgvs_p": "p.Ser159Ser",
          "transcript": "ENST00000577982.1",
          "protein_id": "ENSP00000464301.1",
          "transcript_support_level": 5,
          "aa_start": 159,
          "aa_end": null,
          "aa_length": 180,
          "cds_start": 477,
          "cds_end": null,
          "cds_length": 544,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000577982.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_acceptor_variant",
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.416-2A>G",
          "hgvs_p": null,
          "transcript": "ENST00000879118.1",
          "protein_id": "ENSP00000549177.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 324,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 975,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879118.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.416-35A>G",
          "hgvs_p": null,
          "transcript": "ENST00000879120.1",
          "protein_id": "ENSP00000549179.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 313,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 942,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879120.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.415+3017A>G",
          "hgvs_p": null,
          "transcript": "ENST00000879113.1",
          "protein_id": "ENSP00000549172.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 282,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 849,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879113.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
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          "intron_rank_end": null,
          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.415+3017A>G",
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          "transcript": "ENST00000879122.1",
          "protein_id": "ENSP00000549181.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 222,
          "cds_start": null,
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          "cds_length": 669,
          "cdna_start": null,
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          "cdna_length": null,
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          "biotype": "protein_coding",
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        {
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          "exon_count": 5,
          "intron_rank": 4,
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          "gene_symbol": "APOH",
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          "hgvs_c": "c.415+3017A>G",
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          "transcript": "ENST00000879121.1",
          "protein_id": "ENSP00000549180.1",
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          "aa_start": null,
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          "cds_length": 471,
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          "biotype": "protein_coding",
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        {
          "aa_ref": null,
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          "protein_coding": true,
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          "gene_symbol": "APOH",
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          "transcript": "ENST00000879123.1",
          "protein_id": "ENSP00000549182.1",
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          "biotype": "protein_coding",
          "feature": "ENST00000879123.1"
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        {
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          "gene_symbol": "APOH",
          "gene_hgnc_id": 616,
          "hgvs_c": "c.-52A>G",
          "hgvs_p": null,
          "transcript": "ENST00000585162.1",
          "protein_id": "ENSP00000462260.1",
          "transcript_support_level": 2,
          "aa_start": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000585162.1"
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      ],
      "gene_symbol": "APOH",
      "gene_hgnc_id": 616,
      "dbsnp": "rs8178925",
      "frequency_reference_population": 0.00042994553,
      "hom_count_reference_population": 3,
      "allele_count_reference_population": 694,
      "gnomad_exomes_af": 0.000210004,
      "gnomad_genomes_af": 0.0025414,
      "gnomad_exomes_ac": 307,
      "gnomad_genomes_ac": 387,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 3,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.8299999833106995,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.83,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -0.887,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -11,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6_Moderate,BP7,BS2",
      "acmg_by_gene": [
        {
          "score": -11,
          "benign_score": 11,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6_Moderate",
            "BP7",
            "BS2"
          ],
          "verdict": "Benign",
          "transcript": "NM_000042.3",
          "gene_symbol": "APOH",
          "hgnc_id": 616,
          "effects": [
            "synonymous_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.477A>G",
          "hgvs_p": "p.Ser159Ser"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "B:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Benign",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.