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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-7224011-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=7224011&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM1",
            "PM2",
            "PM5",
            "PP3_Strong",
            "PP5"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "ACADVL",
          "hgnc_id": 92,
          "hgvs_c": "c.1445G>C",
          "hgvs_p": "p.Arg482Pro",
          "inheritance_mode": "AR",
          "pathogenic_score": 11,
          "score": 11,
          "transcript": "NM_001270447.2",
          "verdict": "Pathogenic"
        }
      ],
      "acmg_classification": "Pathogenic",
      "acmg_criteria": "PM1,PM2,PM5,PP3_Strong,PP5",
      "acmg_score": 11,
      "allele_count_reference_population": 1,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.9443,
      "alt": "C",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Pathogenic",
      "bayesdelnoaf_score": 0.51,
      "chr": "17",
      "clinvar_classification": "Conflicting classifications of pathogenicity",
      "clinvar_disease": "Very long chain acyl-CoA dehydrogenase deficiency,not specified",
      "clinvar_review_status": "criteria provided, conflicting classifications",
      "clinvar_submissions_summary": "LP:1 US:2",
      "computational_prediction_selected": "Pathogenic",
      "computational_score_selected": 0.9872204065322876,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 655,
          "aa_ref": "R",
          "aa_start": 459,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2184,
          "cdna_start": 1423,
          "cds_end": null,
          "cds_length": 1968,
          "cds_start": 1376,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "NM_000018.4",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1376G>C",
          "hgvs_p": "p.Arg459Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000356839.10",
          "protein_coding": true,
          "protein_id": "NP_000009.1",
          "strand": true,
          "transcript": "NM_000018.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 655,
          "aa_ref": "R",
          "aa_start": 459,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2184,
          "cdna_start": 1423,
          "cds_end": null,
          "cds_length": 1968,
          "cds_start": 1376,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000356839.10",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1376G>C",
          "hgvs_p": "p.Arg459Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_000018.4",
          "protein_coding": true,
          "protein_id": "ENSP00000349297.5",
          "strand": true,
          "transcript": "ENST00000356839.10",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 633,
          "aa_ref": "R",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2191,
          "cdna_start": 1432,
          "cds_end": null,
          "cds_length": 1902,
          "cds_start": 1310,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 19,
          "exon_rank": 13,
          "exon_rank_end": null,
          "feature": "ENST00000350303.9",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1310G>C",
          "hgvs_p": "p.Arg437Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000344152.5",
          "strand": true,
          "transcript": "ENST00000350303.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 678,
          "aa_ref": "R",
          "aa_start": 482,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2227,
          "cdna_start": 1466,
          "cds_end": null,
          "cds_length": 2037,
          "cds_start": 1445,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": 15,
          "exon_rank_end": null,
          "feature": "NM_001270447.2",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1445G>C",
          "hgvs_p": "p.Arg482Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001257376.1",
          "strand": true,
          "transcript": "NM_001270447.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 678,
          "aa_ref": "R",
          "aa_start": 482,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2227,
          "cdna_start": 1466,
          "cds_end": null,
          "cds_length": 2037,
          "cds_start": 1445,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": 15,
          "exon_rank_end": null,
          "feature": "ENST00000543245.6",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1445G>C",
          "hgvs_p": "p.Arg482Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000438689.2",
          "strand": true,
          "transcript": "ENST00000543245.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 669,
          "aa_ref": "R",
          "aa_start": 473,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2268,
          "cdna_start": 1508,
          "cds_end": null,
          "cds_length": 2010,
          "cds_start": 1418,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000945302.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1418G>C",
          "hgvs_p": "p.Arg473Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000615361.1",
          "strand": true,
          "transcript": "ENST00000945302.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 665,
          "aa_ref": "R",
          "aa_start": 469,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2269,
          "cdna_start": 1510,
          "cds_end": null,
          "cds_length": 1998,
          "cds_start": 1406,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000883761.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1406G>C",
          "hgvs_p": "p.Arg469Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553820.1",
          "strand": true,
          "transcript": "ENST00000883761.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 663,
          "aa_ref": "R",
          "aa_start": 467,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2223,
          "cdna_start": 1463,
          "cds_end": null,
          "cds_length": 1992,
          "cds_start": 1400,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000945308.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1400G>C",
          "hgvs_p": "p.Arg467Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000615367.1",
          "strand": true,
          "transcript": "ENST00000945308.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 661,
          "aa_ref": "R",
          "aa_start": 465,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2218,
          "cdna_start": 1457,
          "cds_end": null,
          "cds_length": 1986,
          "cds_start": 1394,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000883770.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1394G>C",
          "hgvs_p": "p.Arg465Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553829.1",
          "strand": true,
          "transcript": "ENST00000883770.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 655,
          "aa_ref": "R",
          "aa_start": 459,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2227,
          "cdna_start": 1466,
          "cds_end": null,
          "cds_length": 1968,
          "cds_start": 1376,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000916066.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1376G>C",
          "hgvs_p": "p.Arg459Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000586125.1",
          "strand": true,
          "transcript": "ENST00000916066.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 655,
          "aa_ref": "R",
          "aa_start": 459,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2220,
          "cdna_start": 1461,
          "cds_end": null,
          "cds_length": 1968,
          "cds_start": 1376,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000916068.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1376G>C",
          "hgvs_p": "p.Arg459Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000586127.1",
          "strand": true,
          "transcript": "ENST00000916068.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 654,
          "aa_ref": "R",
          "aa_start": 458,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2224,
          "cdna_start": 1463,
          "cds_end": null,
          "cds_length": 1965,
          "cds_start": 1373,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000883764.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1373G>C",
          "hgvs_p": "p.Arg458Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553823.1",
          "strand": true,
          "transcript": "ENST00000883764.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 652,
          "aa_ref": "R",
          "aa_start": 459,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2279,
          "cdna_start": 1526,
          "cds_end": null,
          "cds_length": 1959,
          "cds_start": 1376,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000883757.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1376G>C",
          "hgvs_p": "p.Arg459Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553816.1",
          "strand": true,
          "transcript": "ENST00000883757.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 652,
          "aa_ref": "R",
          "aa_start": 456,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2257,
          "cdna_start": 1498,
          "cds_end": null,
          "cds_length": 1959,
          "cds_start": 1367,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000945291.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1367G>C",
          "hgvs_p": "p.Arg456Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000615350.1",
          "strand": true,
          "transcript": "ENST00000945291.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 651,
          "aa_ref": "R",
          "aa_start": 459,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2215,
          "cdna_start": 1465,
          "cds_end": null,
          "cds_length": 1956,
          "cds_start": 1376,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000945298.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1376G>C",
          "hgvs_p": "p.Arg459Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000615357.1",
          "strand": true,
          "transcript": "ENST00000945298.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 650,
          "aa_ref": "R",
          "aa_start": 454,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2213,
          "cdna_start": 1451,
          "cds_end": null,
          "cds_length": 1953,
          "cds_start": 1361,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000945297.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1361G>C",
          "hgvs_p": "p.Arg454Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000615356.1",
          "strand": true,
          "transcript": "ENST00000945297.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 647,
          "aa_ref": "R",
          "aa_start": 459,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2209,
          "cdna_start": 1524,
          "cds_end": null,
          "cds_length": 1944,
          "cds_start": 1376,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000883762.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1376G>C",
          "hgvs_p": "p.Arg459Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553821.1",
          "strand": true,
          "transcript": "ENST00000883762.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 647,
          "aa_ref": "R",
          "aa_start": 459,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2206,
          "cdna_start": 1469,
          "cds_end": null,
          "cds_length": 1944,
          "cds_start": 1376,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000883763.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1376G>C",
          "hgvs_p": "p.Arg459Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000553822.1",
          "strand": true,
          "transcript": "ENST00000883763.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 647,
          "aa_ref": "R",
          "aa_start": 451,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2225,
          "cdna_start": 1466,
          "cds_end": null,
          "cds_length": 1944,
          "cds_start": 1352,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 19,
          "exon_rank": 13,
          "exon_rank_end": null,
          "feature": "ENST00000945292.1",
          "gene_hgnc_id": 92,
          "gene_symbol": "ACADVL",
          "hgvs_c": "c.1352G>C",
          "hgvs_p": "p.Arg451Pro",
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.