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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-7311583-G-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=7311583&ref=G&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "17",
      "pos": 7311583,
      "ref": "G",
      "alt": "T",
      "effect": "synonymous_variant",
      "transcript": "NM_001143760.1",
      "consequences": [
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.408G>T",
          "hgvs_p": "p.Thr136Thr",
          "transcript": "NM_001970.5",
          "protein_id": "NP_001961.1",
          "transcript_support_level": null,
          "aa_start": 136,
          "aa_end": null,
          "aa_length": 154,
          "cds_start": 408,
          "cds_end": null,
          "cds_length": 465,
          "cdna_start": 554,
          "cdna_end": null,
          "cdna_length": 1264,
          "mane_select": "ENST00000336458.13",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001970.5"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.408G>T",
          "hgvs_p": "p.Thr136Thr",
          "transcript": "ENST00000336458.13",
          "protein_id": "ENSP00000336776.8",
          "transcript_support_level": 1,
          "aa_start": 136,
          "aa_end": null,
          "aa_length": 154,
          "cds_start": 408,
          "cds_end": null,
          "cds_length": 465,
          "cdna_start": 554,
          "cdna_end": null,
          "cdna_length": 1264,
          "mane_select": "NM_001970.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000336458.13"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.498G>T",
          "hgvs_p": "p.Thr166Thr",
          "transcript": "ENST00000336452.11",
          "protein_id": "ENSP00000336702.7",
          "transcript_support_level": 1,
          "aa_start": 166,
          "aa_end": null,
          "aa_length": 184,
          "cds_start": 498,
          "cds_end": null,
          "cds_length": 555,
          "cdna_start": 546,
          "cdna_end": null,
          "cdna_length": 1256,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000336452.11"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.408G>T",
          "hgvs_p": "p.Thr136Thr",
          "transcript": "ENST00000416016.2",
          "protein_id": "ENSP00000396073.2",
          "transcript_support_level": 1,
          "aa_start": 136,
          "aa_end": null,
          "aa_length": 154,
          "cds_start": 408,
          "cds_end": null,
          "cds_length": 465,
          "cdna_start": 634,
          "cdna_end": null,
          "cdna_length": 1336,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000416016.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.408G>T",
          "hgvs_p": "p.Thr136Thr",
          "transcript": "ENST00000419711.6",
          "protein_id": "ENSP00000390677.2",
          "transcript_support_level": 1,
          "aa_start": 136,
          "aa_end": null,
          "aa_length": 154,
          "cds_start": 408,
          "cds_end": null,
          "cds_length": 465,
          "cdna_start": 569,
          "cdna_end": null,
          "cdna_length": 1271,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000419711.6"
        },
        {
          "aa_ref": "P",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GPS2",
          "gene_hgnc_id": 4550,
          "hgvs_c": "c.977C>A",
          "hgvs_p": "p.Pro326Gln",
          "transcript": "ENST00000570780.5",
          "protein_id": "ENSP00000460836.1",
          "transcript_support_level": 5,
          "aa_start": 326,
          "aa_end": null,
          "aa_length": 326,
          "cds_start": 977,
          "cds_end": null,
          "cds_length": 981,
          "cdna_start": 979,
          "cdna_end": null,
          "cdna_length": 1238,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000570780.5"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.504G>T",
          "hgvs_p": "p.Thr168Thr",
          "transcript": "ENST00000572815.5",
          "protein_id": "ENSP00000461688.1",
          "transcript_support_level": 5,
          "aa_start": 168,
          "aa_end": null,
          "aa_length": 186,
          "cds_start": 504,
          "cds_end": null,
          "cds_length": 561,
          "cdna_start": 696,
          "cdna_end": null,
          "cdna_length": 811,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000572815.5"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.504G>T",
          "hgvs_p": "p.Thr168Thr",
          "transcript": "ENST00000894302.1",
          "protein_id": "ENSP00000564361.1",
          "transcript_support_level": null,
          "aa_start": 168,
          "aa_end": null,
          "aa_length": 186,
          "cds_start": 504,
          "cds_end": null,
          "cds_length": 561,
          "cdna_start": 650,
          "cdna_end": null,
          "cdna_length": 1519,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000894302.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.504G>T",
          "hgvs_p": "p.Thr168Thr",
          "transcript": "ENST00000939950.1",
          "protein_id": "ENSP00000610009.1",
          "transcript_support_level": null,
          "aa_start": 168,
          "aa_end": null,
          "aa_length": 186,
          "cds_start": 504,
          "cds_end": null,
          "cds_length": 561,
          "cdna_start": 581,
          "cdna_end": null,
          "cdna_length": 1283,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000939950.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.504G>T",
          "hgvs_p": "p.Thr168Thr",
          "transcript": "ENST00000939956.1",
          "protein_id": "ENSP00000610015.1",
          "transcript_support_level": null,
          "aa_start": 168,
          "aa_end": null,
          "aa_length": 186,
          "cds_start": 504,
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          "cdna_start": 753,
          "cdna_end": null,
          "cdna_length": 1455,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.504G>T",
          "hgvs_p": "p.Thr168Thr",
          "transcript": "ENST00000939963.1",
          "protein_id": "ENSP00000610022.1",
          "transcript_support_level": null,
          "aa_start": 168,
          "aa_end": null,
          "aa_length": 186,
          "cds_start": 504,
          "cds_end": null,
          "cds_length": 561,
          "cdna_start": 618,
          "cdna_end": null,
          "cdna_length": 1320,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 4,
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          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "EIF5A",
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          "hgvs_c": "c.504G>T",
          "hgvs_p": "p.Thr168Thr",
          "transcript": "ENST00000939965.1",
          "protein_id": "ENSP00000610024.1",
          "transcript_support_level": null,
          "aa_start": 168,
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          "cds_start": 504,
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          "cds_length": 561,
          "cdna_start": 837,
          "cdna_end": null,
          "cdna_length": 1539,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.498G>T",
          "hgvs_p": "p.Thr166Thr",
          "transcript": "NM_001143760.1",
          "protein_id": "NP_001137232.1",
          "transcript_support_level": null,
          "aa_start": 166,
          "aa_end": null,
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          "cds_start": 498,
          "cds_end": null,
          "cds_length": 555,
          "cdna_start": 546,
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          "cdna_length": 1256,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001143760.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.408G>T",
          "hgvs_p": "p.Thr136Thr",
          "transcript": "NM_001143761.1",
          "protein_id": "NP_001137233.1",
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          "cds_start": 408,
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          "cdna_start": 574,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
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          "intron_rank": null,
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          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.408G>T",
          "hgvs_p": "p.Thr136Thr",
          "transcript": "NM_001143762.2",
          "protein_id": "NP_001137234.1",
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          "aa_end": null,
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          "cds_start": 408,
          "cds_end": null,
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          "cdna_start": 632,
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          "cdna_length": 1342,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001143762.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.408G>T",
          "hgvs_p": "p.Thr136Thr",
          "transcript": "NM_001370420.1",
          "protein_id": "NP_001357349.1",
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          "aa_end": null,
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          "cds_start": 408,
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          "cdna_start": 541,
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          "cdna_length": 1251,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001370420.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.408G>T",
          "hgvs_p": "p.Thr136Thr",
          "transcript": "NM_001370421.1",
          "protein_id": "NP_001357350.1",
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
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          "consequences": [
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          ],
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          "gene_symbol": "EIF5A",
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          "hgvs_c": "c.408G>T",
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          "transcript": "ENST00000571955.5",
          "protein_id": "ENSP00000458269.1",
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "T",
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          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
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          "gene_symbol": "EIF5A",
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          "hgvs_c": "c.408G>T",
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          "transcript": "ENST00000573542.5",
          "protein_id": "ENSP00000459611.1",
          "transcript_support_level": 2,
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          "cdna_length": 1089,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000573542.5"
        },
        {
          "aa_ref": "T",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EIF5A",
          "gene_hgnc_id": 3300,
          "hgvs_c": "c.408G>T",
          "hgvs_p": "p.Thr136Thr",
          "transcript": "ENST00000576930.5",
          "protein_id": "ENSP00000459196.1",
          "transcript_support_level": 5,
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          "cdna_start": 737,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.