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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-74863110-GCC-AGA (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=74863110&ref=GCC&alt=AGA&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "FDXR",
          "hgnc_id": 3642,
          "hgvs_c": "c.1438_1440delGGCinsTCT",
          "hgvs_p": "p.Gly480Ser",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_001258012.4",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "AGA",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "17",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "G",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1846,
          "cdna_start": 1361,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_024417.5",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1309_1311delGGCinsTCT",
          "hgvs_p": "p.Gly437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000293195.10",
          "protein_coding": true,
          "protein_id": "NP_077728.3",
          "strand": false,
          "transcript": "NM_024417.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 491,
          "aa_ref": "G",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1846,
          "cdna_start": 1361,
          "cds_end": null,
          "cds_length": 1476,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000293195.10",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1309_1311delGGCinsTCT",
          "hgvs_p": "p.Gly437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_024417.5",
          "protein_coding": true,
          "protein_id": "ENSP00000293195.5",
          "strand": false,
          "transcript": "ENST00000293195.10",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 497,
          "aa_ref": "G",
          "aa_start": 443,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1827,
          "cdna_start": 1346,
          "cds_end": null,
          "cds_length": 1494,
          "cds_start": 1327,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000581530.5",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1327_1329delGGCinsTCT",
          "hgvs_p": "p.Gly443Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000462972.1",
          "strand": false,
          "transcript": "ENST00000581530.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2482,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 12,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000578473.5",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "n.1997_1999delGGCinsTCT",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000578473.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 540,
          "aa_ref": "G",
          "aa_start": 486,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1973,
          "cdna_start": 1488,
          "cds_end": null,
          "cds_length": 1623,
          "cds_start": 1456,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000933581.1",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1456_1458delGGCinsTCT",
          "hgvs_p": "p.Gly486Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000603640.1",
          "strand": false,
          "transcript": "ENST00000933581.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 534,
          "aa_ref": "G",
          "aa_start": 480,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1975,
          "cdna_start": 1490,
          "cds_end": null,
          "cds_length": 1605,
          "cds_start": 1438,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001258012.4",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1438_1440delGGCinsTCT",
          "hgvs_p": "p.Gly480Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001244941.2",
          "strand": false,
          "transcript": "NM_001258012.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 534,
          "aa_ref": "G",
          "aa_start": 480,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1967,
          "cdna_start": 1527,
          "cds_end": null,
          "cds_length": 1605,
          "cds_start": 1438,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000442102.6",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1438_1440delGGCinsTCT",
          "hgvs_p": "p.Gly480Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000416515.2",
          "strand": false,
          "transcript": "ENST00000442102.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 523,
          "aa_ref": "G",
          "aa_start": 469,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1915,
          "cdna_start": 1431,
          "cds_end": null,
          "cds_length": 1572,
          "cds_start": 1405,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000946597.1",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1405_1407delGGCinsTCT",
          "hgvs_p": "p.Gly469Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000616656.1",
          "strand": false,
          "transcript": "ENST00000946597.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 522,
          "aa_ref": "G",
          "aa_start": 468,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1939,
          "cdna_start": 1454,
          "cds_end": null,
          "cds_length": 1569,
          "cds_start": 1402,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001258013.4",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1402_1404delGGCinsTCT",
          "hgvs_p": "p.Gly468Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001244942.2",
          "strand": false,
          "transcript": "NM_001258013.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 522,
          "aa_ref": "G",
          "aa_start": 468,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1809,
          "cdna_start": 1436,
          "cds_end": null,
          "cds_length": 1569,
          "cds_start": 1402,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000413947.6",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1402_1404delGGCinsTCT",
          "hgvs_p": "p.Gly468Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000408595.2",
          "strand": false,
          "transcript": "ENST00000413947.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 519,
          "aa_ref": "G",
          "aa_start": 465,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1909,
          "cdna_start": 1425,
          "cds_end": null,
          "cds_length": 1560,
          "cds_start": 1393,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000946595.1",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1393_1395delGGCinsTCT",
          "hgvs_p": "p.Gly465Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000616654.1",
          "strand": false,
          "transcript": "ENST00000946595.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 517,
          "aa_ref": "G",
          "aa_start": 463,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1925,
          "cdna_start": 1444,
          "cds_end": null,
          "cds_length": 1554,
          "cds_start": 1387,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000946589.1",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1387_1389delGGCinsTCT",
          "hgvs_p": "p.Gly463Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000616648.1",
          "strand": false,
          "transcript": "ENST00000946589.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 507,
          "aa_ref": "G",
          "aa_start": 453,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1888,
          "cdna_start": 1407,
          "cds_end": null,
          "cds_length": 1524,
          "cds_start": 1357,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000946592.1",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1357_1359delGGCinsTCT",
          "hgvs_p": "p.Gly453Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000616651.1",
          "strand": false,
          "transcript": "ENST00000946592.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 501,
          "aa_ref": "G",
          "aa_start": 437,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1876,
          "cdna_start": 1361,
          "cds_end": null,
          "cds_length": 1506,
          "cds_start": 1309,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000933578.1",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1309_1311delGGCinsTCT",
          "hgvs_p": "p.Gly437Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000603637.1",
          "strand": false,
          "transcript": "ENST00000933578.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 498,
          "aa_ref": "G",
          "aa_start": 444,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1845,
          "cdna_start": 1362,
          "cds_end": null,
          "cds_length": 1497,
          "cds_start": 1330,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000868980.1",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1330_1332delGGCinsTCT",
          "hgvs_p": "p.Gly444Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000539039.1",
          "strand": false,
          "transcript": "ENST00000868980.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 497,
          "aa_ref": "G",
          "aa_start": 443,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1864,
          "cdna_start": 1379,
          "cds_end": null,
          "cds_length": 1494,
          "cds_start": 1327,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_004110.6",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1327_1329delGGCinsTCT",
          "hgvs_p": "p.Gly443Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_004101.3",
          "strand": false,
          "transcript": "NM_004110.6",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 493,
          "aa_ref": "G",
          "aa_start": 439,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1828,
          "cdna_start": 1347,
          "cds_end": null,
          "cds_length": 1482,
          "cds_start": 1315,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000946596.1",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1315_1317delGGCinsTCT",
          "hgvs_p": "p.Gly439Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000616655.1",
          "strand": false,
          "transcript": "ENST00000946596.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 492,
          "aa_ref": "G",
          "aa_start": 438,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1895,
          "cdna_start": 1409,
          "cds_end": null,
          "cds_length": 1479,
          "cds_start": 1312,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000868974.1",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1312_1314delGGCinsTCT",
          "hgvs_p": "p.Gly438Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000539033.1",
          "strand": false,
          "transcript": "ENST00000868974.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 490,
          "aa_ref": "G",
          "aa_start": 436,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1833,
          "cdna_start": 1348,
          "cds_end": null,
          "cds_length": 1473,
          "cds_start": 1306,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000868979.1",
          "gene_hgnc_id": 3642,
          "gene_symbol": "FDXR",
          "hgvs_c": "c.1306_1308delGGCinsTCT",
          "hgvs_p": "p.Gly436Ser",
          "intron_rank": null,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.