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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 17-75239838-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=75239838&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "17",
      "pos": 75239838,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_138619.4",
      "consequences": [
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1534G>A",
          "hgvs_p": "p.Ala512Thr",
          "transcript": "NM_138619.4",
          "protein_id": "NP_619525.1",
          "transcript_support_level": null,
          "aa_start": 512,
          "aa_end": null,
          "aa_length": 723,
          "cds_start": 1534,
          "cds_end": null,
          "cds_length": 2172,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000537686.6",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_138619.4"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1534G>A",
          "hgvs_p": "p.Ala512Thr",
          "transcript": "ENST00000537686.6",
          "protein_id": "ENSP00000438085.3",
          "transcript_support_level": 1,
          "aa_start": 512,
          "aa_end": null,
          "aa_length": 723,
          "cds_start": 1534,
          "cds_end": null,
          "cds_length": 2172,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_138619.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000537686.6"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1435G>A",
          "hgvs_p": "p.Ala479Thr",
          "transcript": "ENST00000538886.5",
          "protein_id": "ENSP00000446421.2",
          "transcript_support_level": 1,
          "aa_start": 479,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1435,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000538886.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "n.*1493G>A",
          "hgvs_p": null,
          "transcript": "ENST00000621870.4",
          "protein_id": "ENSP00000479464.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000621870.4"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "n.*1493G>A",
          "hgvs_p": null,
          "transcript": "ENST00000621870.4",
          "protein_id": "ENSP00000479464.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000621870.4"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1534G>A",
          "hgvs_p": "p.Ala512Thr",
          "transcript": "ENST00000924703.1",
          "protein_id": "ENSP00000594762.1",
          "transcript_support_level": null,
          "aa_start": 512,
          "aa_end": null,
          "aa_length": 723,
          "cds_start": 1534,
          "cds_end": null,
          "cds_length": 2172,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924703.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1534G>A",
          "hgvs_p": "p.Ala512Thr",
          "transcript": "ENST00000924699.1",
          "protein_id": "ENSP00000594758.1",
          "transcript_support_level": null,
          "aa_start": 512,
          "aa_end": null,
          "aa_length": 721,
          "cds_start": 1534,
          "cds_end": null,
          "cds_length": 2166,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924699.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1534G>A",
          "hgvs_p": "p.Ala512Thr",
          "transcript": "ENST00000924706.1",
          "protein_id": "ENSP00000594765.1",
          "transcript_support_level": null,
          "aa_start": 512,
          "aa_end": null,
          "aa_length": 716,
          "cds_start": 1534,
          "cds_end": null,
          "cds_length": 2151,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924706.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1534G>A",
          "hgvs_p": "p.Ala512Thr",
          "transcript": "ENST00000924702.1",
          "protein_id": "ENSP00000594761.1",
          "transcript_support_level": null,
          "aa_start": 512,
          "aa_end": null,
          "aa_length": 703,
          "cds_start": 1534,
          "cds_end": null,
          "cds_length": 2112,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924702.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1468G>A",
          "hgvs_p": "p.Ala490Thr",
          "transcript": "ENST00000955609.1",
          "protein_id": "ENSP00000625668.1",
          "transcript_support_level": null,
          "aa_start": 490,
          "aa_end": null,
          "aa_length": 701,
          "cds_start": 1468,
          "cds_end": null,
          "cds_length": 2106,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000955609.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1435G>A",
          "hgvs_p": "p.Ala479Thr",
          "transcript": "NM_014001.5",
          "protein_id": "NP_054720.1",
          "transcript_support_level": null,
          "aa_start": 479,
          "aa_end": null,
          "aa_length": 690,
          "cds_start": 1435,
          "cds_end": null,
          "cds_length": 2073,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_014001.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1435G>A",
          "hgvs_p": "p.Ala479Thr",
          "transcript": "ENST00000924705.1",
          "protein_id": "ENSP00000594764.1",
          "transcript_support_level": null,
          "aa_start": 479,
          "aa_end": null,
          "aa_length": 688,
          "cds_start": 1435,
          "cds_end": null,
          "cds_length": 2067,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924705.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1369G>A",
          "hgvs_p": "p.Ala457Thr",
          "transcript": "ENST00000924704.1",
          "protein_id": "ENSP00000594763.1",
          "transcript_support_level": null,
          "aa_start": 457,
          "aa_end": null,
          "aa_length": 668,
          "cds_start": 1369,
          "cds_end": null,
          "cds_length": 2007,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924704.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1351G>A",
          "hgvs_p": "p.Ala451Thr",
          "transcript": "ENST00000924701.1",
          "protein_id": "ENSP00000594760.1",
          "transcript_support_level": null,
          "aa_start": 451,
          "aa_end": null,
          "aa_length": 662,
          "cds_start": 1351,
          "cds_end": null,
          "cds_length": 1989,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000924701.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1318G>A",
          "hgvs_p": "p.Ala440Thr",
          "transcript": "NM_001172703.3",
          "protein_id": "NP_001166174.1",
          "transcript_support_level": null,
          "aa_start": 440,
          "aa_end": null,
          "aa_length": 651,
          "cds_start": 1318,
          "cds_end": null,
          "cds_length": 1956,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001172703.3"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1318G>A",
          "hgvs_p": "p.Ala440Thr",
          "transcript": "NM_001291641.2",
          "protein_id": "NP_001278570.1",
          "transcript_support_level": null,
          "aa_start": 440,
          "aa_end": null,
          "aa_length": 651,
          "cds_start": 1318,
          "cds_end": null,
          "cds_length": 1956,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001291641.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1318G>A",
          "hgvs_p": "p.Ala440Thr",
          "transcript": "ENST00000582717.5",
          "protein_id": "ENSP00000462081.1",
          "transcript_support_level": 2,
          "aa_start": 440,
          "aa_end": null,
          "aa_length": 651,
          "cds_start": 1318,
          "cds_end": null,
          "cds_length": 1956,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000582717.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1312G>A",
          "hgvs_p": "p.Ala438Thr",
          "transcript": "ENST00000878323.1",
          "protein_id": "ENSP00000548382.1",
          "transcript_support_level": null,
          "aa_start": 438,
          "aa_end": null,
          "aa_length": 649,
          "cds_start": 1312,
          "cds_end": null,
          "cds_length": 1950,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000878323.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1318G>A",
          "hgvs_p": "p.Ala440Thr",
          "transcript": "ENST00000582486.5",
          "protein_id": "ENSP00000462629.1",
          "transcript_support_level": 5,
          "aa_start": 440,
          "aa_end": null,
          "aa_length": 632,
          "cds_start": 1318,
          "cds_end": null,
          "cds_length": 1899,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000582486.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GGA3",
          "gene_hgnc_id": 17079,
          "hgvs_c": "c.1252G>A",
          "hgvs_p": "p.Ala418Thr",
          "transcript": "ENST00000924707.1",
          "protein_id": "ENSP00000594766.1",
          "transcript_support_level": null,
          "aa_start": 418,
          "aa_end": null,
          "aa_length": 629,
          "cds_start": 1252,
          "cds_end": null,
          "cds_length": 1890,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
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      ],
      "gene_symbol": "GGA3",
      "gene_hgnc_id": 17079,
      "dbsnp": "rs141316552",
      "frequency_reference_population": 0.00049567706,
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      "allele_count_reference_population": 800,
      "gnomad_exomes_af": 0.000486445,
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      "gnomad_exomes_ac": 711,
      "gnomad_genomes_ac": 89,
      "gnomad_exomes_homalt": 9,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.0025920569896698,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.008,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0574,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.76,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -0.842,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
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      "acmg_score": -10,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6_Moderate,BS2",
      "acmg_by_gene": [
        {
          "score": -10,
          "benign_score": 10,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6_Moderate",
            "BS2"
          ],
          "verdict": "Benign",
          "transcript": "NM_138619.4",
          "gene_symbol": "GGA3",
          "hgnc_id": 17079,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
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          "hgvs_p": "p.Ala512Thr"
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      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LB:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}