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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-7577851-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=7577851&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 7577851,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_001416.4",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.931C>A",
"hgvs_p": "p.Arg311Arg",
"transcript": "NM_001416.4",
"protein_id": "NP_001407.1",
"transcript_support_level": null,
"aa_start": 311,
"aa_end": null,
"aa_length": 406,
"cds_start": 931,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000293831.13",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001416.4"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.931C>A",
"hgvs_p": "p.Arg311Arg",
"transcript": "ENST00000293831.13",
"protein_id": "ENSP00000293831.8",
"transcript_support_level": 1,
"aa_start": 311,
"aa_end": null,
"aa_length": 406,
"cds_start": 931,
"cds_end": null,
"cds_length": 1221,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001416.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000293831.13"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.931C>A",
"hgvs_p": "p.Arg311Arg",
"transcript": "ENST00000577269.5",
"protein_id": "ENSP00000463486.1",
"transcript_support_level": 1,
"aa_start": 311,
"aa_end": null,
"aa_length": 347,
"cds_start": 931,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000577269.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP3-EIF4A1",
"gene_hgnc_id": 49182,
"hgvs_c": "n.*1377C>A",
"hgvs_p": null,
"transcript": "ENST00000614237.1",
"protein_id": "ENSP00000483614.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000614237.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SENP3-EIF4A1",
"gene_hgnc_id": 49182,
"hgvs_c": "n.*1377C>A",
"hgvs_p": null,
"transcript": "ENST00000614237.1",
"protein_id": "ENSP00000483614.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000614237.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.979C>A",
"hgvs_p": "p.Arg327Arg",
"transcript": "ENST00000879166.1",
"protein_id": "ENSP00000549225.1",
"transcript_support_level": null,
"aa_start": 327,
"aa_end": null,
"aa_length": 422,
"cds_start": 979,
"cds_end": null,
"cds_length": 1269,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879166.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.928C>A",
"hgvs_p": "p.Arg310Arg",
"transcript": "ENST00000934298.1",
"protein_id": "ENSP00000604357.1",
"transcript_support_level": null,
"aa_start": 310,
"aa_end": null,
"aa_length": 405,
"cds_start": 928,
"cds_end": null,
"cds_length": 1218,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934298.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.922C>A",
"hgvs_p": "p.Arg308Arg",
"transcript": "ENST00000934300.1",
"protein_id": "ENSP00000604359.1",
"transcript_support_level": null,
"aa_start": 308,
"aa_end": null,
"aa_length": 403,
"cds_start": 922,
"cds_end": null,
"cds_length": 1212,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934300.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.922C>A",
"hgvs_p": "p.Arg308Arg",
"transcript": "ENST00000934301.1",
"protein_id": "ENSP00000604360.1",
"transcript_support_level": null,
"aa_start": 308,
"aa_end": null,
"aa_length": 403,
"cds_start": 922,
"cds_end": null,
"cds_length": 1212,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934301.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.919C>A",
"hgvs_p": "p.Arg307Arg",
"transcript": "ENST00000934299.1",
"protein_id": "ENSP00000604358.1",
"transcript_support_level": null,
"aa_start": 307,
"aa_end": null,
"aa_length": 402,
"cds_start": 919,
"cds_end": null,
"cds_length": 1209,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934299.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.910C>A",
"hgvs_p": "p.Arg304Arg",
"transcript": "ENST00000879167.1",
"protein_id": "ENSP00000549226.1",
"transcript_support_level": null,
"aa_start": 304,
"aa_end": null,
"aa_length": 399,
"cds_start": 910,
"cds_end": null,
"cds_length": 1200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879167.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.886C>A",
"hgvs_p": "p.Arg296Arg",
"transcript": "ENST00000879169.1",
"protein_id": "ENSP00000549228.1",
"transcript_support_level": null,
"aa_start": 296,
"aa_end": null,
"aa_length": 391,
"cds_start": 886,
"cds_end": null,
"cds_length": 1176,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879169.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.877C>A",
"hgvs_p": "p.Arg293Arg",
"transcript": "ENST00000879168.1",
"protein_id": "ENSP00000549227.1",
"transcript_support_level": null,
"aa_start": 293,
"aa_end": null,
"aa_length": 388,
"cds_start": 877,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879168.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.844C>A",
"hgvs_p": "p.Arg282Arg",
"transcript": "ENST00000934304.1",
"protein_id": "ENSP00000604363.1",
"transcript_support_level": null,
"aa_start": 282,
"aa_end": null,
"aa_length": 377,
"cds_start": 844,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934304.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.931C>A",
"hgvs_p": "p.Arg311Arg",
"transcript": "NM_001204510.2",
"protein_id": "NP_001191439.1",
"transcript_support_level": null,
"aa_start": 311,
"aa_end": null,
"aa_length": 347,
"cds_start": 931,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001204510.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.931C>A",
"hgvs_p": "p.Arg311Arg",
"transcript": "ENST00000582746.5",
"protein_id": "ENSP00000462753.1",
"transcript_support_level": 5,
"aa_start": 311,
"aa_end": null,
"aa_length": 341,
"cds_start": 931,
"cds_end": null,
"cds_length": 1026,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000582746.5"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.652C>A",
"hgvs_p": "p.Arg218Arg",
"transcript": "ENST00000934302.1",
"protein_id": "ENSP00000604361.1",
"transcript_support_level": null,
"aa_start": 218,
"aa_end": null,
"aa_length": 313,
"cds_start": 652,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934302.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.577C>A",
"hgvs_p": "p.Arg193Arg",
"transcript": "ENST00000583389.5",
"protein_id": "ENSP00000462719.1",
"transcript_support_level": 3,
"aa_start": 193,
"aa_end": null,
"aa_length": 229,
"cds_start": 577,
"cds_end": null,
"cds_length": 690,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000583389.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "c.906+145C>A",
"hgvs_p": null,
"transcript": "ENST00000934303.1",
"protein_id": "ENSP00000604362.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 376,
"cds_start": null,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934303.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "n.716C>A",
"hgvs_p": null,
"transcript": "ENST00000396527.7",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000396527.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "n.909C>A",
"hgvs_p": null,
"transcript": "ENST00000578324.5",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000578324.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "EIF4A1",
"gene_hgnc_id": 3282,
"hgvs_c": "n.503C>A",
"hgvs_p": null,
"transcript": "ENST00000578569.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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"biotype": "retained_intron",
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{
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{
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}
],
"message": null
}