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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-773986-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=773986&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 773986,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000301329.11",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.406+1789G>A",
"hgvs_p": null,
"transcript": "NM_016080.4",
"protein_id": "NP_057164.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 298,
"cds_start": -4,
"cds_end": null,
"cds_length": 897,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1765,
"mane_select": "ENST00000301329.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.406+1789G>A",
"hgvs_p": null,
"transcript": "ENST00000301329.11",
"protein_id": "ENSP00000301329.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 298,
"cds_start": -4,
"cds_end": null,
"cds_length": 897,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1765,
"mane_select": "NM_016080.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.451+1789G>A",
"hgvs_p": null,
"transcript": "ENST00000301328.9",
"protein_id": "ENSP00000301328.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": -4,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1809,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.604+1789G>A",
"hgvs_p": null,
"transcript": "NM_001389725.1",
"protein_id": "NP_001376654.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 364,
"cds_start": -4,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1963,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.517+1789G>A",
"hgvs_p": null,
"transcript": "NM_001389726.1",
"protein_id": "NP_001376655.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 335,
"cds_start": -4,
"cds_end": null,
"cds_length": 1008,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1876,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.406+1789G>A",
"hgvs_p": null,
"transcript": "NM_001389727.1",
"protein_id": "NP_001376656.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 326,
"cds_start": -4,
"cds_end": null,
"cds_length": 981,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1134,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.451+1789G>A",
"hgvs_p": null,
"transcript": "NM_001366247.2",
"protein_id": "NP_001353176.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 313,
"cds_start": -4,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1810,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.379+1789G>A",
"hgvs_p": null,
"transcript": "NM_001366249.2",
"protein_id": "NP_001353178.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 289,
"cds_start": -4,
"cds_end": null,
"cds_length": 870,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2141,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.379+1789G>A",
"hgvs_p": null,
"transcript": "NM_001366250.2",
"protein_id": "NP_001353179.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 289,
"cds_start": -4,
"cds_end": null,
"cds_length": 870,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1838,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.379+1789G>A",
"hgvs_p": null,
"transcript": "NM_001389728.1",
"protein_id": "NP_001376657.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 289,
"cds_start": -4,
"cds_end": null,
"cds_length": 870,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2019,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.379+1789G>A",
"hgvs_p": null,
"transcript": "NM_001389729.1",
"protein_id": "NP_001376658.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 289,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 1893,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 5,
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"gene_symbol": "GLOD4",
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"hgvs_c": "c.379+1789G>A",
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"transcript": "NM_001389730.1",
"protein_id": "NP_001376659.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 4,
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"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.406+1789G>A",
"hgvs_p": null,
"transcript": "NM_001389731.1",
"protein_id": "NP_001376660.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 9,
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"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.406+1789G>A",
"hgvs_p": null,
"transcript": "NM_001389732.1",
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},
{
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],
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"gene_symbol": "GLOD4",
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"hgvs_c": "c.406+1789G>A",
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"transcript": "NM_001389733.1",
"protein_id": "NP_001376662.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.406+1789G>A",
"hgvs_p": null,
"transcript": "NM_001389734.1",
"protein_id": "NP_001376663.1",
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},
{
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],
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"gene_symbol": "GLOD4",
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"transcript": "NM_001389735.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 4,
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"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "c.238+1789G>A",
"hgvs_p": null,
"transcript": "NM_001366248.2",
"protein_id": "NP_001353177.1",
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"cdna_start": null,
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},
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 4,
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"gene_symbol": "GLOD4",
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"hgvs_c": "c.406+1789G>A",
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"transcript": "NM_001389736.1",
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},
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],
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"intron_rank": 4,
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"gene_symbol": "GLOD4",
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"hgvs_c": "c.406+1789G>A",
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"transcript": "ENST00000576419.1",
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},
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],
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"gene_symbol": "GLOD4",
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},
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 4,
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"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "n.*285+1789G>A",
"hgvs_p": null,
"transcript": "ENST00000572220.1",
"protein_id": "ENSP00000461837.1",
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "GLOD4",
"gene_hgnc_id": 14111,
"hgvs_c": "n.*429+1789G>A",
"hgvs_p": null,
"transcript": "ENST00000574554.5",
"protein_id": "ENSP00000459446.1",
"transcript_support_level": 2,
"aa_start": null,
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},
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}
],
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}