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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-78107603-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=78107603&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 78107603,
"ref": "G",
"alt": "C",
"effect": "3_prime_UTR_variant",
"transcript": "ENST00000590602.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMC6",
"gene_hgnc_id": 18021,
"hgvs_c": "n.2987C>G",
"hgvs_p": null,
"transcript": "ENST00000589217.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3192,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "NM_001142640.2",
"protein_id": "NP_001136112.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1936,
"cds_start": -4,
"cds_end": null,
"cds_length": 5811,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10391,
"mane_select": "ENST00000696270.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "ENST00000696270.1",
"protein_id": "ENSP00000512514.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1936,
"cds_start": -4,
"cds_end": null,
"cds_length": 5811,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10391,
"mane_select": "NM_001142640.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMC6",
"gene_hgnc_id": 18021,
"hgvs_c": "c.*5545C>G",
"hgvs_p": null,
"transcript": "NM_001127198.5",
"protein_id": "NP_001120670.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 805,
"cds_start": -4,
"cds_end": null,
"cds_length": 2418,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8387,
"mane_select": "ENST00000590602.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMC6",
"gene_hgnc_id": 18021,
"hgvs_c": "c.*5545C>G",
"hgvs_p": null,
"transcript": "ENST00000590602.6",
"protein_id": "ENSP00000465261.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 805,
"cds_start": -4,
"cds_end": null,
"cds_length": 2418,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8387,
"mane_select": "NM_001127198.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMC6",
"gene_hgnc_id": 18021,
"hgvs_c": "n.6292C>G",
"hgvs_p": null,
"transcript": "NR_168288.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6498,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMC6",
"gene_hgnc_id": 18021,
"hgvs_c": "n.6971C>G",
"hgvs_p": null,
"transcript": "NR_168289.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7177,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMC6",
"gene_hgnc_id": 18021,
"hgvs_c": "n.6874C>G",
"hgvs_p": null,
"transcript": "NR_168290.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7080,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMC6",
"gene_hgnc_id": 18021,
"hgvs_c": "n.6245C>G",
"hgvs_p": null,
"transcript": "NR_168291.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6451,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "NM_001395509.1",
"protein_id": "NP_001382438.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1905,
"cds_start": -4,
"cds_end": null,
"cds_length": 5718,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10298,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "NM_001395510.1",
"protein_id": "NP_001382439.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1897,
"cds_start": -4,
"cds_end": null,
"cds_length": 5694,
"cdna_start": null,
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"cdna_length": 10274,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "NM_001395511.1",
"protein_id": "NP_001382440.1",
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"aa_start": null,
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"aa_length": 1734,
"cds_start": -4,
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"cds_length": 5205,
"cdna_start": null,
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"cdna_length": 9608,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "NM_001395508.1",
"protein_id": "NP_001382437.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "NM_018996.3",
"protein_id": "NP_061869.2",
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"aa_start": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 23,
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"exon_count": 23,
"intron_rank": null,
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"gene_symbol": "TNRC6C",
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"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "NM_001395512.1",
"protein_id": "NP_001382441.1",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
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"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "XM_047436485.1",
"protein_id": "XP_047292441.1",
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},
{
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"strand": true,
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"3_prime_UTR_variant"
],
"exon_rank": 22,
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"exon_count": 22,
"intron_rank": null,
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"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "XM_047436486.1",
"protein_id": "XP_047292442.1",
"transcript_support_level": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "XM_006721996.5",
"protein_id": "XP_006722059.4",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1939,
"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "XM_047436487.1",
"protein_id": "XP_047292443.1",
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},
{
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"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
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"exon_count": 21,
"intron_rank": null,
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"gene_symbol": "TNRC6C",
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"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "XM_047436488.1",
"protein_id": "XP_047292444.1",
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},
{
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"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
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"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
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"transcript": "XM_006721997.5",
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "XM_047436489.1",
"protein_id": "XP_047292445.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1886,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TNRC6C",
"gene_hgnc_id": 29318,
"hgvs_c": "c.*2758G>C",
"hgvs_p": null,
"transcript": "XM_047436490.1",
"protein_id": "XP_047292446.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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