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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-81809839-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=81809839&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 81809839,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_000160.5",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "NM_000160.5",
"protein_id": "NP_000151.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000400723.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000160.5"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000400723.8",
"protein_id": "ENSP00000383558.3",
"transcript_support_level": 1,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000160.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000400723.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "n.413G>A",
"hgvs_p": null,
"transcript": "ENST00000572185.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000572185.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000570996.5",
"protein_id": "ENSP00000460976.1",
"transcript_support_level": 2,
"aa_start": 40,
"aa_end": null,
"aa_length": 523,
"cds_start": 118,
"cds_end": null,
"cds_length": 1572,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000570996.5"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853053.1",
"protein_id": "ENSP00000523112.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 507,
"cds_start": 118,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853053.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853073.1",
"protein_id": "ENSP00000523132.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 507,
"cds_start": 118,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853073.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853066.1",
"protein_id": "ENSP00000523125.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 506,
"cds_start": 118,
"cds_end": null,
"cds_length": 1521,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853066.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.112G>A",
"hgvs_p": "p.Gly38Ser",
"transcript": "ENST00000853051.1",
"protein_id": "ENSP00000523110.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 505,
"cds_start": 112,
"cds_end": null,
"cds_length": 1518,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853051.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.97G>A",
"hgvs_p": "p.Gly33Ser",
"transcript": "ENST00000853067.1",
"protein_id": "ENSP00000523126.1",
"transcript_support_level": null,
"aa_start": 33,
"aa_end": null,
"aa_length": 500,
"cds_start": 97,
"cds_end": null,
"cds_length": 1503,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853067.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853050.1",
"protein_id": "ENSP00000523109.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853050.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853055.1",
"protein_id": "ENSP00000523114.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853055.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853056.1",
"protein_id": "ENSP00000523115.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853056.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853057.1",
"protein_id": "ENSP00000523116.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853057.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853058.1",
"protein_id": "ENSP00000523117.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853058.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853062.1",
"protein_id": "ENSP00000523121.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853062.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853065.1",
"protein_id": "ENSP00000523124.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853065.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853075.1",
"protein_id": "ENSP00000523134.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853075.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000957520.1",
"protein_id": "ENSP00000627579.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957520.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000957521.1",
"protein_id": "ENSP00000627580.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 477,
"cds_start": 118,
"cds_end": null,
"cds_length": 1434,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957521.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853054.1",
"protein_id": "ENSP00000523113.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 476,
"cds_start": 118,
"cds_end": null,
"cds_length": 1431,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853054.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.112G>A",
"hgvs_p": "p.Gly38Ser",
"transcript": "ENST00000853048.1",
"protein_id": "ENSP00000523107.1",
"transcript_support_level": null,
"aa_start": 38,
"aa_end": null,
"aa_length": 475,
"cds_start": 112,
"cds_end": null,
"cds_length": 1428,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853048.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GCGR",
"gene_hgnc_id": 4192,
"hgvs_c": "c.118G>A",
"hgvs_p": "p.Gly40Ser",
"transcript": "ENST00000853052.1",
"protein_id": "ENSP00000523111.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 475,
"cds_start": 118,
"cds_end": null,
"cds_length": 1428,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000853052.1"
},
{
"aa_ref": "G",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
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}
],
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}