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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-8204967-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=8204967&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 8204967,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001284526.2",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.939G>A",
"hgvs_p": "p.Ser313Ser",
"transcript": "NM_004217.4",
"protein_id": "NP_004208.2",
"transcript_support_level": null,
"aa_start": 313,
"aa_end": null,
"aa_length": 344,
"cds_start": 939,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000585124.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004217.4"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.939G>A",
"hgvs_p": "p.Ser313Ser",
"transcript": "ENST00000585124.6",
"protein_id": "ENSP00000463999.1",
"transcript_support_level": 1,
"aa_start": 313,
"aa_end": null,
"aa_length": 344,
"cds_start": 939,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004217.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000585124.6"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.942G>A",
"hgvs_p": "p.Ser314Ser",
"transcript": "ENST00000316199.10",
"protein_id": "ENSP00000313950.6",
"transcript_support_level": 1,
"aa_start": 314,
"aa_end": null,
"aa_length": 345,
"cds_start": 942,
"cds_end": null,
"cds_length": 1038,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000316199.10"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.843G>A",
"hgvs_p": "p.Ser281Ser",
"transcript": "ENST00000578549.5",
"protein_id": "ENSP00000462207.1",
"transcript_support_level": 1,
"aa_start": 281,
"aa_end": null,
"aa_length": 312,
"cds_start": 843,
"cds_end": null,
"cds_length": 939,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000578549.5"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.948G>A",
"hgvs_p": "p.Ser316Ser",
"transcript": "ENST00000932573.1",
"protein_id": "ENSP00000602632.1",
"transcript_support_level": null,
"aa_start": 316,
"aa_end": null,
"aa_length": 347,
"cds_start": 948,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932573.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.945G>A",
"hgvs_p": "p.Ser315Ser",
"transcript": "ENST00000932561.1",
"protein_id": "ENSP00000602620.1",
"transcript_support_level": null,
"aa_start": 315,
"aa_end": null,
"aa_length": 346,
"cds_start": 945,
"cds_end": null,
"cds_length": 1041,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932561.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.942G>A",
"hgvs_p": "p.Ser314Ser",
"transcript": "NM_001284526.2",
"protein_id": "NP_001271455.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 345,
"cds_start": 942,
"cds_end": null,
"cds_length": 1038,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001284526.2"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.942G>A",
"hgvs_p": "p.Ser314Ser",
"transcript": "ENST00000932564.1",
"protein_id": "ENSP00000602623.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 345,
"cds_start": 942,
"cds_end": null,
"cds_length": 1038,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932564.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.939G>A",
"hgvs_p": "p.Ser313Ser",
"transcript": "NM_001313950.2",
"protein_id": "NP_001300879.1",
"transcript_support_level": null,
"aa_start": 313,
"aa_end": null,
"aa_length": 344,
"cds_start": 939,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001313950.2"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.939G>A",
"hgvs_p": "p.Ser313Ser",
"transcript": "ENST00000881953.1",
"protein_id": "ENSP00000552012.1",
"transcript_support_level": null,
"aa_start": 313,
"aa_end": null,
"aa_length": 344,
"cds_start": 939,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881953.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.939G>A",
"hgvs_p": "p.Ser313Ser",
"transcript": "ENST00000932557.1",
"protein_id": "ENSP00000602616.1",
"transcript_support_level": null,
"aa_start": 313,
"aa_end": null,
"aa_length": 344,
"cds_start": 939,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932557.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.939G>A",
"hgvs_p": "p.Ser313Ser",
"transcript": "ENST00000932558.1",
"protein_id": "ENSP00000602617.1",
"transcript_support_level": null,
"aa_start": 313,
"aa_end": null,
"aa_length": 344,
"cds_start": 939,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932558.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.939G>A",
"hgvs_p": "p.Ser313Ser",
"transcript": "ENST00000932562.1",
"protein_id": "ENSP00000602621.1",
"transcript_support_level": null,
"aa_start": 313,
"aa_end": null,
"aa_length": 344,
"cds_start": 939,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932562.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.939G>A",
"hgvs_p": "p.Ser313Ser",
"transcript": "ENST00000932572.1",
"protein_id": "ENSP00000602631.1",
"transcript_support_level": null,
"aa_start": 313,
"aa_end": null,
"aa_length": 344,
"cds_start": 939,
"cds_end": null,
"cds_length": 1035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932572.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.936G>A",
"hgvs_p": "p.Ser312Ser",
"transcript": "ENST00000932567.1",
"protein_id": "ENSP00000602626.1",
"transcript_support_level": null,
"aa_start": 312,
"aa_end": null,
"aa_length": 343,
"cds_start": 936,
"cds_end": null,
"cds_length": 1032,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932567.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.933G>A",
"hgvs_p": "p.Ser311Ser",
"transcript": "ENST00000932559.1",
"protein_id": "ENSP00000602618.1",
"transcript_support_level": null,
"aa_start": 311,
"aa_end": null,
"aa_length": 342,
"cds_start": 933,
"cds_end": null,
"cds_length": 1029,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932559.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.861G>A",
"hgvs_p": "p.Ser287Ser",
"transcript": "ENST00000932570.1",
"protein_id": "ENSP00000602629.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 318,
"cds_start": 861,
"cds_end": null,
"cds_length": 957,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932570.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.846G>A",
"hgvs_p": "p.Ser282Ser",
"transcript": "ENST00000932560.1",
"protein_id": "ENSP00000602619.1",
"transcript_support_level": null,
"aa_start": 282,
"aa_end": null,
"aa_length": 313,
"cds_start": 846,
"cds_end": null,
"cds_length": 942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932560.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.843G>A",
"hgvs_p": "p.Ser281Ser",
"transcript": "NM_001313953.3",
"protein_id": "NP_001300882.1",
"transcript_support_level": null,
"aa_start": 281,
"aa_end": null,
"aa_length": 312,
"cds_start": 843,
"cds_end": null,
"cds_length": 939,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001313953.3"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Ser280Ser",
"transcript": "ENST00000932563.1",
"protein_id": "ENSP00000602622.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 311,
"cds_start": 840,
"cds_end": null,
"cds_length": 936,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000932563.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.819G>A",
"hgvs_p": "p.Ser273Ser",
"transcript": "NM_001313952.2",
"protein_id": "NP_001300881.1",
"transcript_support_level": null,
"aa_start": 273,
"aa_end": null,
"aa_length": 304,
"cds_start": 819,
"cds_end": null,
"cds_length": 915,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001313952.2"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AURKB",
"gene_hgnc_id": 11390,
"hgvs_c": "c.816G>A",
"hgvs_p": "p.Ser272Ser",
"transcript": "NM_001256834.3",
"protein_id": "NP_001243763.1",
"transcript_support_level": null,
"aa_start": 272,
"aa_end": null,
"aa_length": 303,
"cds_start": 816,
"cds_end": null,
"cds_length": 912,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}
],
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}