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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 18-13116433-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=13116433&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "18",
      "pos": 13116433,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_032142.4",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 43,
          "exon_rank_end": null,
          "exon_count": 45,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7346G>A",
          "hgvs_p": "p.Arg2449Gln",
          "transcript": "NM_032142.4",
          "protein_id": "NP_115518.3",
          "transcript_support_level": null,
          "aa_start": 2449,
          "aa_end": null,
          "aa_length": 2537,
          "cds_start": 7346,
          "cds_end": null,
          "cds_length": 7614,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000506447.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_032142.4"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 43,
          "exon_rank_end": null,
          "exon_count": 45,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7346G>A",
          "hgvs_p": "p.Arg2449Gln",
          "transcript": "ENST00000506447.5",
          "protein_id": "ENSP00000427550.1",
          "transcript_support_level": 5,
          "aa_start": 2449,
          "aa_end": null,
          "aa_length": 2537,
          "cds_start": 7346,
          "cds_end": null,
          "cds_length": 7614,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_032142.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000506447.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.5960G>A",
          "hgvs_p": "p.Arg1987Gln",
          "transcript": "ENST00000511820.6",
          "protein_id": "ENSP00000467038.1",
          "transcript_support_level": 1,
          "aa_start": 1987,
          "aa_end": null,
          "aa_length": 2075,
          "cds_start": 5960,
          "cds_end": null,
          "cds_length": 6228,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000511820.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "n.*204G>A",
          "hgvs_p": null,
          "transcript": "ENST00000510237.5",
          "protein_id": "ENSP00000423147.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000510237.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "n.*6862G>A",
          "hgvs_p": null,
          "transcript": "ENST00000513432.5",
          "protein_id": "ENSP00000424671.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000513432.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "n.*204G>A",
          "hgvs_p": null,
          "transcript": "ENST00000510237.5",
          "protein_id": "ENSP00000423147.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000510237.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "n.*6862G>A",
          "hgvs_p": null,
          "transcript": "ENST00000513432.5",
          "protein_id": "ENSP00000424671.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000513432.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 43,
          "exon_rank_end": null,
          "exon_count": 45,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7349G>A",
          "hgvs_p": "p.Arg2450Gln",
          "transcript": "ENST00000912813.1",
          "protein_id": "ENSP00000582872.1",
          "transcript_support_level": null,
          "aa_start": 2450,
          "aa_end": null,
          "aa_length": 2538,
          "cds_start": 7349,
          "cds_end": null,
          "cds_length": 7617,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912813.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 42,
          "exon_rank_end": null,
          "exon_count": 44,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7346G>A",
          "hgvs_p": "p.Arg2449Gln",
          "transcript": "ENST00000898442.1",
          "protein_id": "ENSP00000568501.1",
          "transcript_support_level": null,
          "aa_start": 2449,
          "aa_end": null,
          "aa_length": 2537,
          "cds_start": 7346,
          "cds_end": null,
          "cds_length": 7614,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000898442.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 43,
          "exon_rank_end": null,
          "exon_count": 45,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7337G>A",
          "hgvs_p": "p.Arg2446Gln",
          "transcript": "ENST00000965466.1",
          "protein_id": "ENSP00000635525.1",
          "transcript_support_level": null,
          "aa_start": 2446,
          "aa_end": null,
          "aa_length": 2534,
          "cds_start": 7337,
          "cds_end": null,
          "cds_length": 7605,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000965466.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 42,
          "exon_rank_end": null,
          "exon_count": 44,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7256G>A",
          "hgvs_p": "p.Arg2419Gln",
          "transcript": "ENST00000912815.1",
          "protein_id": "ENSP00000582874.1",
          "transcript_support_level": null,
          "aa_start": 2419,
          "aa_end": null,
          "aa_length": 2507,
          "cds_start": 7256,
          "cds_end": null,
          "cds_length": 7524,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912815.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 42,
          "exon_rank_end": null,
          "exon_count": 44,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7139G>A",
          "hgvs_p": "p.Arg2380Gln",
          "transcript": "ENST00000912812.1",
          "protein_id": "ENSP00000582871.1",
          "transcript_support_level": null,
          "aa_start": 2380,
          "aa_end": null,
          "aa_length": 2468,
          "cds_start": 7139,
          "cds_end": null,
          "cds_length": 7407,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912812.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 42,
          "exon_rank_end": null,
          "exon_count": 44,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7046G>A",
          "hgvs_p": "p.Arg2349Gln",
          "transcript": "ENST00000912816.1",
          "protein_id": "ENSP00000582875.1",
          "transcript_support_level": null,
          "aa_start": 2349,
          "aa_end": null,
          "aa_length": 2437,
          "cds_start": 7046,
          "cds_end": null,
          "cds_length": 7314,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912816.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 37,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.6329G>A",
          "hgvs_p": "p.Arg2110Gln",
          "transcript": "ENST00000912814.1",
          "protein_id": "ENSP00000582873.1",
          "transcript_support_level": null,
          "aa_start": 2110,
          "aa_end": null,
          "aa_length": 2198,
          "cds_start": 6329,
          "cds_end": null,
          "cds_length": 6597,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000912814.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 42,
          "exon_rank_end": null,
          "exon_count": 44,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.5921G>A",
          "hgvs_p": "p.Arg1974Gln",
          "transcript": "ENST00000325971.12",
          "protein_id": "ENSP00000317156.9",
          "transcript_support_level": 5,
          "aa_start": 1974,
          "aa_end": null,
          "aa_length": 2062,
          "cds_start": 5921,
          "cds_end": null,
          "cds_length": 6189,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000325971.12"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 43,
          "exon_rank_end": null,
          "exon_count": 45,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7349G>A",
          "hgvs_p": "p.Arg2450Gln",
          "transcript": "XM_005258107.4",
          "protein_id": "XP_005258164.1",
          "transcript_support_level": null,
          "aa_start": 2450,
          "aa_end": null,
          "aa_length": 2538,
          "cds_start": 7349,
          "cds_end": null,
          "cds_length": 7617,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_005258107.4"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 43,
          "exon_rank_end": null,
          "exon_count": 45,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7349G>A",
          "hgvs_p": "p.Arg2450Gln",
          "transcript": "XM_006722326.4",
          "protein_id": "XP_006722389.1",
          "transcript_support_level": null,
          "aa_start": 2450,
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          "aa_length": 2506,
          "cds_start": 7349,
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          "cds_length": 7521,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_006722326.4"
        },
        {
          "aa_ref": "R",
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          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 43,
          "exon_rank_end": null,
          "exon_count": 45,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7346G>A",
          "hgvs_p": "p.Arg2449Gln",
          "transcript": "XM_047437562.1",
          "protein_id": "XP_047293518.1",
          "transcript_support_level": null,
          "aa_start": 2449,
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          "aa_length": 2505,
          "cds_start": 7346,
          "cds_end": null,
          "cds_length": 7518,
          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047437562.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 42,
          "exon_rank_end": null,
          "exon_count": 44,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7175G>A",
          "hgvs_p": "p.Arg2392Gln",
          "transcript": "XM_011525673.3",
          "protein_id": "XP_011523975.1",
          "transcript_support_level": null,
          "aa_start": 2392,
          "aa_end": null,
          "aa_length": 2480,
          "cds_start": 7175,
          "cds_end": null,
          "cds_length": 7443,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011525673.3"
        },
        {
          "aa_ref": "R",
          "aa_alt": "Q",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 42,
          "exon_rank_end": null,
          "exon_count": 44,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "c.7172G>A",
          "hgvs_p": "p.Arg2391Gln",
          "transcript": "XM_047437563.1",
          "protein_id": "XP_047293519.1",
          "transcript_support_level": null,
          "aa_start": 2391,
          "aa_end": null,
          "aa_length": 2479,
          "cds_start": 7172,
          "cds_end": null,
          "cds_length": 7440,
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          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000540847.6"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
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          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "n.*48G>A",
          "hgvs_p": null,
          "transcript": "ENST00000589993.5",
          "protein_id": "ENSP00000467297.1",
          "transcript_support_level": 5,
          "aa_start": null,
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          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000589993.5"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CEP192",
          "gene_hgnc_id": 25515,
          "hgvs_c": "n.*48G>A",
          "hgvs_p": null,
          "transcript": "ENST00000589993.5",
          "protein_id": "ENSP00000467297.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000589993.5"
        }
      ],
      "gene_symbol": "CEP192",
      "gene_hgnc_id": 25515,
      "dbsnp": "rs1786263",
      "frequency_reference_population": 0.0000020550817,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 3,
      "gnomad_exomes_af": 0.00000205508,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 3,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.09485408663749695,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.091,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.076,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.62,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.555,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
          "score": 0,
          "benign_score": 2,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_032142.4",
          "gene_symbol": "CEP192",
          "hgnc_id": 25515,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.7346G>A",
          "hgvs_p": "p.Arg2449Gln"
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}