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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 18-21515583-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=21515583&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "18",
"pos": 21515583,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000424526.7",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5068G>A",
"hgvs_p": "p.Val1690Met",
"transcript": "NM_001142966.3",
"protein_id": "NP_001136438.1",
"transcript_support_level": null,
"aa_start": 1690,
"aa_end": null,
"aa_length": 1923,
"cds_start": 5068,
"cds_end": null,
"cds_length": 5772,
"cdna_start": 5349,
"cdna_end": null,
"cdna_length": 9344,
"mane_select": "ENST00000424526.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5068G>A",
"hgvs_p": "p.Val1690Met",
"transcript": "ENST00000424526.7",
"protein_id": "ENSP00000412060.1",
"transcript_support_level": 5,
"aa_start": 1690,
"aa_end": null,
"aa_length": 1923,
"cds_start": 5068,
"cds_end": null,
"cds_length": 5772,
"cdna_start": 5349,
"cdna_end": null,
"cdna_length": 9344,
"mane_select": "NM_001142966.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5197G>A",
"hgvs_p": "p.Val1733Met",
"transcript": "NM_001410867.1",
"protein_id": "NP_001397796.1",
"transcript_support_level": null,
"aa_start": 1733,
"aa_end": null,
"aa_length": 1966,
"cds_start": 5197,
"cds_end": null,
"cds_length": 5901,
"cdna_start": 5478,
"cdna_end": null,
"cdna_length": 9473,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5197G>A",
"hgvs_p": "p.Val1733Met",
"transcript": "ENST00000579454.2",
"protein_id": "ENSP00000463926.2",
"transcript_support_level": 5,
"aa_start": 1733,
"aa_end": null,
"aa_length": 1966,
"cds_start": 5197,
"cds_end": null,
"cds_length": 5901,
"cdna_start": 5451,
"cdna_end": null,
"cdna_length": 6155,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5068G>A",
"hgvs_p": "p.Val1690Met",
"transcript": "ENST00000580732.6",
"protein_id": "ENSP00000464162.1",
"transcript_support_level": 5,
"aa_start": 1690,
"aa_end": null,
"aa_length": 1923,
"cds_start": 5068,
"cds_end": null,
"cds_length": 5772,
"cdna_start": 5449,
"cdna_end": null,
"cdna_length": 8749,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.4741G>A",
"hgvs_p": "p.Val1581Met",
"transcript": "NM_001410868.1",
"protein_id": "NP_001397797.1",
"transcript_support_level": null,
"aa_start": 1581,
"aa_end": null,
"aa_length": 1814,
"cds_start": 4741,
"cds_end": null,
"cds_length": 5445,
"cdna_start": 5022,
"cdna_end": null,
"cdna_length": 9017,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.4741G>A",
"hgvs_p": "p.Val1581Met",
"transcript": "ENST00000269218.10",
"protein_id": "ENSP00000269218.6",
"transcript_support_level": 5,
"aa_start": 1581,
"aa_end": null,
"aa_length": 1814,
"cds_start": 4741,
"cds_end": null,
"cds_length": 5445,
"cdna_start": 4896,
"cdna_end": null,
"cdna_length": 5600,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.250G>A",
"hgvs_p": "p.Val84Met",
"transcript": "ENST00000580384.1",
"protein_id": "ENSP00000462152.1",
"transcript_support_level": 3,
"aa_start": 84,
"aa_end": null,
"aa_length": 188,
"cds_start": 250,
"cds_end": null,
"cds_length": 567,
"cdna_start": 251,
"cdna_end": null,
"cdna_length": 568,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5200G>A",
"hgvs_p": "p.Val1734Met",
"transcript": "XM_017025989.2",
"protein_id": "XP_016881478.1",
"transcript_support_level": null,
"aa_start": 1734,
"aa_end": null,
"aa_length": 1998,
"cds_start": 5200,
"cds_end": null,
"cds_length": 5997,
"cdna_start": 5371,
"cdna_end": null,
"cdna_length": 7472,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5200G>A",
"hgvs_p": "p.Val1734Met",
"transcript": "XM_047437809.1",
"protein_id": "XP_047293765.1",
"transcript_support_level": null,
"aa_start": 1734,
"aa_end": null,
"aa_length": 1998,
"cds_start": 5200,
"cds_end": null,
"cds_length": 5997,
"cdna_start": 5481,
"cdna_end": null,
"cdna_length": 7582,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5200G>A",
"hgvs_p": "p.Val1734Met",
"transcript": "XM_047437810.1",
"protein_id": "XP_047293766.1",
"transcript_support_level": null,
"aa_start": 1734,
"aa_end": null,
"aa_length": 1998,
"cds_start": 5200,
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"cds_length": 5997,
"cdna_start": 5559,
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"cdna_length": 7660,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5197G>A",
"hgvs_p": "p.Val1733Met",
"transcript": "XM_017025990.2",
"protein_id": "XP_016881479.1",
"transcript_support_level": null,
"aa_start": 1733,
"aa_end": null,
"aa_length": 1997,
"cds_start": 5197,
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"cds_length": 5994,
"cdna_start": 5478,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5116G>A",
"hgvs_p": "p.Val1706Met",
"transcript": "XM_017025991.2",
"protein_id": "XP_016881480.1",
"transcript_support_level": null,
"aa_start": 1706,
"aa_end": null,
"aa_length": 1970,
"cds_start": 5116,
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"cds_length": 5913,
"cdna_start": 5397,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
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"exon_count": 32,
"intron_rank": null,
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"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5113G>A",
"hgvs_p": "p.Val1705Met",
"transcript": "XM_047437811.1",
"protein_id": "XP_047293767.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
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"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5200G>A",
"hgvs_p": "p.Val1734Met",
"transcript": "XM_006722547.4",
"protein_id": "XP_006722610.1",
"transcript_support_level": null,
"aa_start": 1734,
"aa_end": null,
"aa_length": 1967,
"cds_start": 5200,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
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"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5071G>A",
"hgvs_p": "p.Val1691Met",
"transcript": "XM_017025993.2",
"protein_id": "XP_016881482.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5071G>A",
"hgvs_p": "p.Val1691Met",
"transcript": "XM_047437813.1",
"protein_id": "XP_047293769.1",
"transcript_support_level": null,
"aa_start": 1691,
"aa_end": null,
"aa_length": 1955,
"cds_start": 5071,
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"cdna_start": 5352,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
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"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5071G>A",
"hgvs_p": "p.Val1691Met",
"transcript": "XM_047437814.1",
"protein_id": "XP_047293770.1",
"transcript_support_level": null,
"aa_start": 1691,
"aa_end": null,
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"cds_start": 5071,
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},
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],
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"intron_rank": null,
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"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5068G>A",
"hgvs_p": "p.Val1690Met",
"transcript": "XM_047437815.1",
"protein_id": "XP_047293771.1",
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},
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"protein_coding": true,
"strand": true,
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],
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"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5113G>A",
"hgvs_p": "p.Val1705Met",
"transcript": "XM_047437816.1",
"protein_id": "XP_047293772.1",
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},
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"strand": true,
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],
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"intron_rank": null,
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"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.4987G>A",
"hgvs_p": "p.Val1663Met",
"transcript": "XM_047437817.1",
"protein_id": "XP_047293773.1",
"transcript_support_level": null,
"aa_start": 1663,
"aa_end": null,
"aa_length": 1927,
"cds_start": 4987,
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"cdna_start": 5268,
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"cdna_length": 7369,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GREB1L",
"gene_hgnc_id": 31042,
"hgvs_c": "c.5071G>A",
"hgvs_p": "p.Val1691Met",
"transcript": "XM_047437818.1",
"protein_id": "XP_047293774.1",
"transcript_support_level": null,
"aa_start": 1691,
"aa_end": null,
"aa_length": 1924,
"cds_start": 5071,
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"cdna_start": 5242,
"cdna_end": null,
"cdna_length": 9237,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "M",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 33,
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