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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 18-23299253-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=23299253&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 12,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "SLC35D4",
          "hgnc_id": 31723,
          "hgvs_c": "c.831-1186G>A",
          "hgvs_p": null,
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": -12,
          "transcript": "NM_032933.6",
          "verdict": "Benign"
        },
        {
          "benign_score": 12,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "TMEM241",
          "hgnc_id": 31723,
          "hgvs_c": "c.831-1186G>A",
          "hgvs_p": null,
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": -12,
          "transcript": "ENST00000383233.8",
          "verdict": "Benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BA1",
      "acmg_score": -12,
      "allele_count_reference_population": 33283,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.94,
      "chr": "18",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.9399999976158142,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 296,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2994,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 891,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 15,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_032933.6",
          "gene_hgnc_id": 31723,
          "gene_symbol": "SLC35D4",
          "hgvs_c": "c.831-1186G>A",
          "hgvs_p": null,
          "intron_rank": 14,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000383233.8",
          "protein_coding": true,
          "protein_id": "NP_116322.3",
          "strand": false,
          "transcript": "NM_032933.6",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 296,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2994,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 891,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 15,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000383233.8",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.831-1186G>A",
          "hgvs_p": null,
          "intron_rank": 14,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_032933.6",
          "protein_coding": true,
          "protein_id": "ENSP00000372720.3",
          "strand": false,
          "transcript": "ENST00000383233.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 149,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1022,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 450,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 16,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000542162.5",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.*496-1186G>A",
          "hgvs_p": null,
          "intron_rank": 15,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000440152.2",
          "strand": false,
          "transcript": "ENST00000542162.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2941,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 14,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000473688.5",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "n.*302-1186G>A",
          "hgvs_p": null,
          "intron_rank": 13,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000431584.1",
          "strand": false,
          "transcript": "ENST00000473688.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2350,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000475185.5",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "n.296-1186G>A",
          "hgvs_p": null,
          "intron_rank": 2,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000475185.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 338,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3100,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1017,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 16,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000907354.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.831-835G>A",
          "hgvs_p": null,
          "intron_rank": 14,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577413.1",
          "strand": false,
          "transcript": "ENST00000907354.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 330,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3076,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 993,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 16,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000938585.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.933-1186G>A",
          "hgvs_p": null,
          "intron_rank": 15,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000608644.1",
          "strand": false,
          "transcript": "ENST00000938585.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 310,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3030,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 933,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 16,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000907353.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.873-1186G>A",
          "hgvs_p": null,
          "intron_rank": 15,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577412.1",
          "strand": false,
          "transcript": "ENST00000907353.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 270,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2920,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 813,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 14,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000907352.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.753-1186G>A",
          "hgvs_p": null,
          "intron_rank": 13,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577411.1",
          "strand": false,
          "transcript": "ENST00000907352.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 270,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2926,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 813,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 14,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000938583.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.753-1186G>A",
          "hgvs_p": null,
          "intron_rank": 13,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000608642.1",
          "strand": false,
          "transcript": "ENST00000938583.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 258,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2866,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 777,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000951849.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.717-1186G>A",
          "hgvs_p": null,
          "intron_rank": 12,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000621908.1",
          "strand": false,
          "transcript": "ENST00000951849.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 253,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2864,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 762,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000938584.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.702-1186G>A",
          "hgvs_p": null,
          "intron_rank": 12,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000608643.1",
          "strand": false,
          "transcript": "ENST00000938584.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 244,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2824,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 735,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 13,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000951850.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.675-1186G>A",
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          "intron_rank": 12,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000621909.1",
          "strand": false,
          "transcript": "ENST00000951850.1",
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        },
        {
          "aa_alt": null,
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          "aa_length": 227,
          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2763,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 684,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 12,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000907355.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.624-1186G>A",
          "hgvs_p": null,
          "intron_rank": 11,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577414.1",
          "strand": false,
          "transcript": "ENST00000907355.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 201,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5321,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 606,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 11,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000938582.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "TMEM241",
          "hgvs_c": "c.546-1186G>A",
          "hgvs_p": null,
          "intron_rank": 10,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000608641.1",
          "strand": false,
          "transcript": "ENST00000938582.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 175,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3109,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 528,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 16,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001318834.2",
          "gene_hgnc_id": 31723,
          "gene_symbol": "SLC35D4",
          "hgvs_c": "c.468-1186G>A",
          "hgvs_p": null,
          "intron_rank": 15,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001305763.1",
          "strand": false,
          "transcript": "NM_001318834.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 381,
          "aa_ref": null,
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3088,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1146,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 16,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_047437891.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "SLC35D4",
          "hgvs_c": "c.831-253G>A",
          "hgvs_p": null,
          "intron_rank": 14,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047293847.1",
          "strand": false,
          "transcript": "XM_047437891.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 330,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3096,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 993,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 16,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_011526233.3",
          "gene_hgnc_id": 31723,
          "gene_symbol": "SLC35D4",
          "hgvs_c": "c.933-1186G>A",
          "hgvs_p": null,
          "intron_rank": 15,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_011524535.1",
          "strand": false,
          "transcript": "XM_011526233.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 318,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3060,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 957,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 15,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_047437892.1",
          "gene_hgnc_id": 31723,
          "gene_symbol": "SLC35D4",
          "hgvs_c": "c.897-1186G>A",
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}
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