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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 18-2951199-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=2951199&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "18",
      "pos": 2951199,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_014646.2",
      "consequences": [
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "NM_001375808.2",
          "protein_id": "NP_001362737.1",
          "transcript_support_level": null,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 896,
          "cds_start": 446,
          "cds_end": null,
          "cds_length": 2691,
          "cdna_start": 513,
          "cdna_end": null,
          "cdna_length": 6052,
          "mane_select": "ENST00000677752.1",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001375808.2"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "ENST00000677752.1",
          "protein_id": "ENSP00000504857.1",
          "transcript_support_level": null,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 896,
          "cds_start": 446,
          "cds_end": null,
          "cds_length": 2691,
          "cdna_start": 513,
          "cdna_end": null,
          "cdna_length": 6052,
          "mane_select": "NM_001375808.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000677752.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "ENST00000261596.9",
          "protein_id": "ENSP00000261596.4",
          "transcript_support_level": 1,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 896,
          "cds_start": 446,
          "cds_end": null,
          "cds_length": 2691,
          "cdna_start": 755,
          "cdna_end": null,
          "cdna_length": 6299,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000261596.9"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "NM_001375809.1",
          "protein_id": "NP_001362738.1",
          "transcript_support_level": null,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 896,
          "cds_start": 446,
          "cds_end": null,
          "cds_length": 2691,
          "cdna_start": 563,
          "cdna_end": null,
          "cdna_length": 6102,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001375809.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "NM_014646.2",
          "protein_id": "NP_055461.1",
          "transcript_support_level": null,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 896,
          "cds_start": 446,
          "cds_end": null,
          "cds_length": 2691,
          "cdna_start": 685,
          "cdna_end": null,
          "cdna_length": 6229,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_014646.2"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "ENST00000697040.1",
          "protein_id": "ENSP00000513062.1",
          "transcript_support_level": null,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 896,
          "cds_start": 446,
          "cds_end": null,
          "cds_length": 2691,
          "cdna_start": 561,
          "cdna_end": null,
          "cdna_length": 6092,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000697040.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "ENST00000897964.1",
          "protein_id": "ENSP00000568025.1",
          "transcript_support_level": null,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 896,
          "cds_start": 446,
          "cds_end": null,
          "cds_length": 2691,
          "cdna_start": 1175,
          "cdna_end": null,
          "cdna_length": 6714,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000897964.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 24,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "ENST00000897967.1",
          "protein_id": "ENSP00000568026.1",
          "transcript_support_level": null,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 896,
          "cds_start": 446,
          "cds_end": null,
          "cds_length": 2691,
          "cdna_start": 1133,
          "cdna_end": null,
          "cdna_length": 3978,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000897967.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "ENST00000897968.1",
          "protein_id": "ENSP00000568027.1",
          "transcript_support_level": null,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 896,
          "cds_start": 446,
          "cds_end": null,
          "cds_length": 2691,
          "cdna_start": 694,
          "cdna_end": null,
          "cdna_length": 3255,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000897968.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "ENST00000897969.1",
          "protein_id": "ENSP00000568028.1",
          "transcript_support_level": null,
          "aa_start": 149,
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          "cds_start": 446,
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          "cdna_start": 888,
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          "cdna_length": 6424,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
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          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "ENST00000912763.1",
          "protein_id": "ENSP00000582822.1",
          "transcript_support_level": null,
          "aa_start": 149,
          "aa_end": null,
          "aa_length": 896,
          "cds_start": 446,
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          "cdna_start": 1146,
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          "cdna_length": 6685,
          "mane_select": null,
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        {
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          "consequences": [
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          ],
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          "intron_rank": null,
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          "gene_symbol": "LPIN2",
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          "hgvs_c": "c.446C>T",
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          "transcript": "ENST00000912764.1",
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          "cdna_start": 575,
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        {
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 5,
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          "gene_symbol": "LPIN2",
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          "hgvs_c": "c.446C>T",
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          "transcript": "ENST00000912765.1",
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          "cdna_start": 1157,
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        },
        {
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 4,
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          "exon_count": 20,
          "intron_rank": null,
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          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "ENST00000697039.1",
          "protein_id": "ENSP00000513061.1",
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        },
        {
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          "gene_symbol": "LPIN2",
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          "hgvs_c": "c.446C>T",
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          "transcript": "ENST00000697042.1",
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          "cdna_start": 541,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000697042.1"
        },
        {
          "aa_ref": "P",
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          "canonical": false,
          "protein_coding": true,
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          "consequences": [
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          ],
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          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.557C>T",
          "hgvs_p": "p.Pro186Leu",
          "transcript": "ENST00000584915.2",
          "protein_id": "ENSP00000463810.2",
          "transcript_support_level": 3,
          "aa_start": 186,
          "aa_end": null,
          "aa_length": 197,
          "cds_start": 557,
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        },
        {
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          "exon_rank": 4,
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          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "ENST00000697043.1",
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        {
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          "gene_symbol": "LPIN2",
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        },
        {
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          "intron_rank": null,
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          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.458C>T",
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          "transcript": "XM_047437958.1",
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "P",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LPIN2",
          "gene_hgnc_id": 14450,
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu",
          "transcript": "XM_017026099.2",
          "protein_id": "XP_016881588.1",
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          "feature": "XM_017026099.2"
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          "exon_count": 20,
          "intron_rank": null,
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          "transcript": "XM_047437959.1",
          "protein_id": "XP_047293915.1",
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          "cds_start": 446,
          "cds_end": null,
          "cds_length": 2691,
          "cdna_start": 4403,
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          "cdna_length": 9947,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
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          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "LPIN2-AS1",
          "gene_hgnc_id": 58311,
          "hgvs_c": "n.395G>A",
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          "transcript": "ENST00000584431.1",
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 673,
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          "biotype": "pseudogene",
          "feature": "ENST00000584431.1"
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        {
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          "protein_coding": false,
          "strand": true,
          "consequences": [
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          "exon_rank": 2,
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          "exon_count": 2,
          "intron_rank": null,
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          "gene_symbol": "LPIN2-AS1",
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          "hgvs_c": "n.1022G>A",
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          "transcript": "ENST00000665001.1",
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          "cdna_length": 3421,
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        {
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          "consequences": [
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          "exon_count": 12,
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          "gene_symbol": "LPIN2",
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          "hgvs_c": "n.563C>T",
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          "transcript": "XR_935074.3",
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          "cdna_length": 1840,
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          "biotype": "pseudogene",
          "feature": "XR_935074.3"
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      ],
      "gene_symbol": "LPIN2",
      "gene_hgnc_id": 14450,
      "dbsnp": "rs147615538",
      "frequency_reference_population": 0.00045537285,
      "hom_count_reference_population": 1,
      "allele_count_reference_population": 735,
      "gnomad_exomes_af": 0.000465151,
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      "gnomad_exomes_ac": 680,
      "gnomad_genomes_ac": 55,
      "gnomad_exomes_homalt": 1,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.014722466468811035,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.265,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0839,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.26,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 5.36,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -9,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6,BS1",
      "acmg_by_gene": [
        {
          "score": -9,
          "benign_score": 9,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6",
            "BS1"
          ],
          "verdict": "Benign",
          "transcript": "NM_014646.2",
          "gene_symbol": "LPIN2",
          "hgnc_id": 14450,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.446C>T",
          "hgvs_p": "p.Pro149Leu"
        },
        {
          "score": -5,
          "benign_score": 5,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6"
          ],
          "verdict": "Likely_benign",
          "transcript": "ENST00000584431.1",
          "gene_symbol": "LPIN2-AS1",
          "hgnc_id": 58311,
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.395G>A",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "Autoinflammatory syndrome,Majeed syndrome,not provided",
      "clinvar_classification": "Conflicting classifications of pathogenicity",
      "clinvar_review_status": "criteria provided, conflicting classifications",
      "clinvar_submissions_summary": "US:3 LB:3",
      "phenotype_combined": "Majeed syndrome|not provided|Autoinflammatory syndrome",
      "pathogenicity_classification_combined": "Conflicting classifications of pathogenicity",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.