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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 18-31069144-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=31069144&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "18",
"pos": 31069144,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000280904.11",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2258C>T",
"hgvs_p": "p.Ala753Val",
"transcript": "NM_024422.6",
"protein_id": "NP_077740.1",
"transcript_support_level": null,
"aa_start": 753,
"aa_end": null,
"aa_length": 901,
"cds_start": 2258,
"cds_end": null,
"cds_length": 2706,
"cdna_start": 2708,
"cdna_end": null,
"cdna_length": 12331,
"mane_select": "ENST00000280904.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2258C>T",
"hgvs_p": "p.Ala753Val",
"transcript": "ENST00000280904.11",
"protein_id": "ENSP00000280904.6",
"transcript_support_level": 1,
"aa_start": 753,
"aa_end": null,
"aa_length": 901,
"cds_start": 2258,
"cds_end": null,
"cds_length": 2706,
"cdna_start": 2708,
"cdna_end": null,
"cdna_length": 12331,
"mane_select": "NM_024422.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2258C>T",
"hgvs_p": "p.Ala753Val",
"transcript": "ENST00000251081.8",
"protein_id": "ENSP00000251081.6",
"transcript_support_level": 1,
"aa_start": 753,
"aa_end": null,
"aa_length": 847,
"cds_start": 2258,
"cds_end": null,
"cds_length": 2544,
"cdna_start": 2708,
"cdna_end": null,
"cdna_length": 12377,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2279C>T",
"hgvs_p": "p.Ala760Val",
"transcript": "ENST00000713707.1",
"protein_id": "ENSP00000519010.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 908,
"cds_start": 2279,
"cds_end": null,
"cds_length": 2727,
"cdna_start": 2731,
"cdna_end": null,
"cdna_length": 5218,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2255C>T",
"hgvs_p": "p.Ala752Val",
"transcript": "ENST00000713705.1",
"protein_id": "ENSP00000519008.1",
"transcript_support_level": null,
"aa_start": 752,
"aa_end": null,
"aa_length": 900,
"cds_start": 2255,
"cds_end": null,
"cds_length": 2703,
"cdna_start": 2647,
"cdna_end": null,
"cdna_length": 5134,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2249C>T",
"hgvs_p": "p.Ala750Val",
"transcript": "ENST00000713702.1",
"protein_id": "ENSP00000519005.1",
"transcript_support_level": null,
"aa_start": 750,
"aa_end": null,
"aa_length": 898,
"cds_start": 2249,
"cds_end": null,
"cds_length": 2697,
"cdna_start": 2697,
"cdna_end": null,
"cdna_length": 5188,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2123C>T",
"hgvs_p": "p.Ala708Val",
"transcript": "ENST00000713682.1",
"protein_id": "ENSP00000518985.1",
"transcript_support_level": null,
"aa_start": 708,
"aa_end": null,
"aa_length": 856,
"cds_start": 2123,
"cds_end": null,
"cds_length": 2571,
"cdna_start": 2584,
"cdna_end": null,
"cdna_length": 5071,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2258C>T",
"hgvs_p": "p.Ala753Val",
"transcript": "ENST00000713704.1",
"protein_id": "ENSP00000519007.1",
"transcript_support_level": null,
"aa_start": 753,
"aa_end": null,
"aa_length": 853,
"cds_start": 2258,
"cds_end": null,
"cds_length": 2562,
"cdna_start": 2412,
"cdna_end": null,
"cdna_length": 4895,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2258C>T",
"hgvs_p": "p.Ala753Val",
"transcript": "NM_004949.5",
"protein_id": "NP_004940.1",
"transcript_support_level": null,
"aa_start": 753,
"aa_end": null,
"aa_length": 847,
"cds_start": 2258,
"cds_end": null,
"cds_length": 2544,
"cdna_start": 2708,
"cdna_end": null,
"cdna_length": 12377,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2249C>T",
"hgvs_p": "p.Ala750Val",
"transcript": "ENST00000713706.1",
"protein_id": "ENSP00000519009.1",
"transcript_support_level": null,
"aa_start": 750,
"aa_end": null,
"aa_length": 844,
"cds_start": 2249,
"cds_end": null,
"cds_length": 2535,
"cdna_start": 2697,
"cdna_end": null,
"cdna_length": 5230,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2258C>T",
"hgvs_p": "p.Ala753Val",
"transcript": "ENST00000713722.1",
"protein_id": "ENSP00000519025.1",
"transcript_support_level": null,
"aa_start": 753,
"aa_end": null,
"aa_length": 839,
"cds_start": 2258,
"cds_end": null,
"cds_length": 2520,
"cdna_start": 2687,
"cdna_end": null,
"cdna_length": 5169,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2249C>T",
"hgvs_p": "p.Ala750Val",
"transcript": "ENST00000713703.1",
"protein_id": "ENSP00000519006.1",
"transcript_support_level": null,
"aa_start": 750,
"aa_end": null,
"aa_length": 836,
"cds_start": 2249,
"cds_end": null,
"cds_length": 2511,
"cdna_start": 2702,
"cdna_end": null,
"cdna_length": 5188,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.2033C>T",
"hgvs_p": "p.Ala678Val",
"transcript": "ENST00000713720.1",
"protein_id": "ENSP00000519023.1",
"transcript_support_level": null,
"aa_start": 678,
"aa_end": null,
"aa_length": 772,
"cds_start": 2033,
"cds_end": null,
"cds_length": 2319,
"cdna_start": 2495,
"cdna_end": null,
"cdna_length": 5029,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.1829C>T",
"hgvs_p": "p.Ala610Val",
"transcript": "NM_001406506.1",
"protein_id": "NP_001393435.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 758,
"cds_start": 1829,
"cds_end": null,
"cds_length": 2277,
"cdna_start": 2229,
"cdna_end": null,
"cdna_length": 11852,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.1829C>T",
"hgvs_p": "p.Ala610Val",
"transcript": "ENST00000648081.1",
"protein_id": "ENSP00000497441.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 758,
"cds_start": 1829,
"cds_end": null,
"cds_length": 2277,
"cdna_start": 2313,
"cdna_end": null,
"cdna_length": 4778,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.1829C>T",
"hgvs_p": "p.Ala610Val",
"transcript": "ENST00000682357.1",
"protein_id": "ENSP00000507826.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 758,
"cds_start": 1829,
"cds_end": null,
"cds_length": 2277,
"cdna_start": 2257,
"cdna_end": null,
"cdna_length": 4722,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.1829C>T",
"hgvs_p": "p.Ala610Val",
"transcript": "ENST00000713681.1",
"protein_id": "ENSP00000518984.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 758,
"cds_start": 1829,
"cds_end": null,
"cds_length": 2277,
"cdna_start": 2323,
"cdna_end": null,
"cdna_length": 4812,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.1829C>T",
"hgvs_p": "p.Ala610Val",
"transcript": "ENST00000713683.1",
"protein_id": "ENSP00000518986.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 758,
"cds_start": 1829,
"cds_end": null,
"cds_length": 2277,
"cdna_start": 2215,
"cdna_end": null,
"cdna_length": 4702,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.1829C>T",
"hgvs_p": "p.Ala610Val",
"transcript": "ENST00000713685.1",
"protein_id": "ENSP00000518988.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 758,
"cds_start": 1829,
"cds_end": null,
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"cdna_start": 2328,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.1829C>T",
"hgvs_p": "p.Ala610Val",
"transcript": "ENST00000713721.1",
"protein_id": "ENSP00000519024.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 758,
"cds_start": 1829,
"cds_end": null,
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"cdna_start": 2234,
"cdna_end": null,
"cdna_length": 4721,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.1829C>T",
"hgvs_p": "p.Ala610Val",
"transcript": "ENST00000850650.1",
"protein_id": "ENSP00000518963.1",
"transcript_support_level": null,
"aa_start": 610,
"aa_end": null,
"aa_length": 758,
"cds_start": 1829,
"cds_end": null,
"cds_length": 2277,
"cdna_start": 2499,
"cdna_end": null,
"cdna_length": 4068,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.1697C>T",
"hgvs_p": "p.Ala566Val",
"transcript": "ENST00000713684.1",
"protein_id": "ENSP00000518987.1",
"transcript_support_level": null,
"aa_start": 566,
"aa_end": null,
"aa_length": 714,
"cds_start": 1697,
"cds_end": null,
"cds_length": 2145,
"cdna_start": 2184,
"cdna_end": null,
"cdna_length": 4607,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"hgvs_c": "c.1829C>T",
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"aa_start": 610,
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},
{
"aa_ref": "A",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
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"exon_count": 17,
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"gene_symbol": "DSC2",
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
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"exon_count": 16,
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"transcript": "ENST00000713708.1",
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"cdna_length": 4700,
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},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
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"exon_count": 17,
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"gene_symbol": "DSC2",
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"hgvs_c": "n.*1881C>T",
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"transcript": "ENST00000850651.1",
"protein_id": "ENSP00000518989.1",
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
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"gene_symbol": "DSC2",
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},
{
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"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
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"gene_symbol": "DSC2",
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"hgvs_c": "n.*1881C>T",
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"transcript": "ENST00000850651.1",
"protein_id": "ENSP00000518989.1",
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"cdna_length": 3003,
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"biotype": null,
"feature": null
}
],
"gene_symbol": "DSC2",
"gene_hgnc_id": 3036,
"dbsnp": "rs1217851416",
"frequency_reference_population": 0.000009294037,
"hom_count_reference_population": 0,
"allele_count_reference_population": 15,
"gnomad_exomes_af": 0.00000957722,
"gnomad_genomes_af": 0.00000657307,
"gnomad_exomes_ac": 14,
"gnomad_genomes_ac": 1,
"gnomad_exomes_homalt": 0,
"gnomad_genomes_homalt": 0,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": 0.07193788886070251,
"computational_prediction_selected": "Benign",
"computational_source_selected": "MetaRNN",
"splice_score_selected": 0.03999999910593033,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": 0.063,
"revel_prediction": "Benign",
"alphamissense_score": 0.0949,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.54,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 1.747,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0.04,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": -2,
"acmg_classification": "Likely_benign",
"acmg_criteria": "BP4_Moderate",
"acmg_by_gene": [
{
"score": -2,
"benign_score": 2,
"pathogenic_score": 0,
"criteria": [
"BP4_Moderate"
],
"verdict": "Likely_benign",
"transcript": "ENST00000280904.11",
"gene_symbol": "DSC2",
"hgnc_id": 3036,
"effects": [
"missense_variant"
],
"inheritance_mode": "AR,AD,SD",
"hgvs_c": "c.2258C>T",
"hgvs_p": "p.Ala753Val"
}
],
"clinvar_disease": "Arrhythmogenic right ventricular dysplasia 11,Cardiomyopathy,Cardiovascular phenotype,Familial isolated arrhythmogenic right ventricular dysplasia,not provided",
"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
"clinvar_submissions_summary": "US:6",
"phenotype_combined": "Arrhythmogenic right ventricular dysplasia 11|Cardiomyopathy|Cardiovascular phenotype|not provided|Familial isolated arrhythmogenic right ventricular dysplasia",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}