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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 18-34091638-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=34091638&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "18",
"pos": 34091638,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000261592.10",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.772+1827C>G",
"hgvs_p": null,
"transcript": "NM_003787.5",
"protein_id": "NP_003778.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 638,
"cds_start": -4,
"cds_end": null,
"cds_length": 1917,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5319,
"mane_select": "ENST00000261592.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.772+1827C>G",
"hgvs_p": null,
"transcript": "ENST00000261592.10",
"protein_id": "ENSP00000261592.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 638,
"cds_start": -4,
"cds_end": null,
"cds_length": 1917,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5319,
"mane_select": "NM_003787.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.772+1827C>G",
"hgvs_p": null,
"transcript": "ENST00000589544.5",
"protein_id": "ENSP00000465450.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 536,
"cds_start": -4,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2221,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.841+1827C>G",
"hgvs_p": null,
"transcript": "NM_001384467.1",
"protein_id": "NP_001371396.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 661,
"cds_start": -4,
"cds_end": null,
"cds_length": 1986,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5388,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.841+1827C>G",
"hgvs_p": null,
"transcript": "NM_001384468.1",
"protein_id": "NP_001371397.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 597,
"cds_start": -4,
"cds_end": null,
"cds_length": 1794,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5196,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.835+1827C>G",
"hgvs_p": null,
"transcript": "NM_001384469.1",
"protein_id": "NP_001371398.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 595,
"cds_start": -4,
"cds_end": null,
"cds_length": 1788,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5190,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.772+1827C>G",
"hgvs_p": null,
"transcript": "NM_001198546.1",
"protein_id": "NP_001185475.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 574,
"cds_start": -4,
"cds_end": null,
"cds_length": 1725,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3765,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.550+1827C>G",
"hgvs_p": null,
"transcript": "NM_001198547.2",
"protein_id": "NP_001185476.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 564,
"cds_start": -4,
"cds_end": null,
"cds_length": 1695,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3846,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.550+1827C>G",
"hgvs_p": null,
"transcript": "ENST00000538587.5",
"protein_id": "ENSP00000443472.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 564,
"cds_start": -4,
"cds_end": null,
"cds_length": 1695,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1979,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.724+1827C>G",
"hgvs_p": null,
"transcript": "ENST00000590712.5",
"protein_id": "ENSP00000467629.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 558,
"cds_start": -4,
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"cds_length": 1677,
"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.772+1827C>G",
"hgvs_p": null,
"transcript": "NM_001198548.1",
"protein_id": "NP_001185477.1",
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"aa_start": null,
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
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"gene_symbol": "NOL4",
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"hgvs_c": "c.772+1827C>G",
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"transcript": "NM_001353232.1",
"protein_id": "NP_001340161.1",
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},
{
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"strand": false,
"consequences": [
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],
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"intron_rank": 5,
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"gene_symbol": "NOL4",
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"hgvs_c": "c.550+1827C>G",
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"transcript": "NM_001353234.2",
"protein_id": "NP_001340163.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 6,
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"gene_symbol": "NOL4",
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"hgvs_c": "c.307+1827C>G",
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"transcript": "NM_001353235.2",
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},
{
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],
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"gene_symbol": "NOL4",
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"transcript": "NM_001384470.1",
"protein_id": "NP_001371399.1",
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},
{
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],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 6,
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"gene_symbol": "NOL4",
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"hgvs_c": "c.307+1827C>G",
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"transcript": "NM_001282527.2",
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},
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],
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"gene_symbol": "NOL4",
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"hgvs_c": "c.307+1827C>G",
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"transcript": "NM_001353237.1",
"protein_id": "NP_001340166.1",
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},
{
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"strand": false,
"consequences": [
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],
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"exon_count": 12,
"intron_rank": 7,
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"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.307+1827C>G",
"hgvs_p": null,
"transcript": "NM_001384471.1",
"protein_id": "NP_001371400.1",
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},
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "NOL4",
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"hgvs_c": "c.-194+1827C>G",
"hgvs_p": null,
"transcript": "NM_001353233.1",
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},
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],
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"gene_symbol": "NOL4",
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},
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],
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"gene_symbol": "NOL4",
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},
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "n.*381+1827C>G",
"hgvs_p": null,
"transcript": "ENST00000586314.5",
"protein_id": "ENSP00000464704.1",
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"aa_start": null,
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "NOL4",
"gene_hgnc_id": 7870,
"hgvs_c": "c.772+1827C>G",
"hgvs_p": null,
"transcript": "XM_006722563.4",
"protein_id": "XP_006722626.1",
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