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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 18-3457572-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=3457572&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "18",
"pos": 3457572,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_173207.4",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.451A>G",
"hgvs_p": "p.Thr151Ala",
"transcript": "NM_003244.4",
"protein_id": "NP_003235.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 272,
"cds_start": 451,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000343820.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003244.4"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.451A>G",
"hgvs_p": "p.Thr151Ala",
"transcript": "ENST00000343820.10",
"protein_id": "ENSP00000339631.6",
"transcript_support_level": 1,
"aa_start": 151,
"aa_end": null,
"aa_length": 272,
"cds_start": 451,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_003244.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000343820.10"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "ENST00000330513.10",
"protein_id": "ENSP00000327959.6",
"transcript_support_level": 1,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000330513.10"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.493A>G",
"hgvs_p": "p.Thr165Ala",
"transcript": "NM_173207.4",
"protein_id": "NP_775299.1",
"transcript_support_level": null,
"aa_start": 165,
"aa_end": null,
"aa_length": 286,
"cds_start": 493,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_173207.4"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.493A>G",
"hgvs_p": "p.Thr165Ala",
"transcript": "ENST00000618001.4",
"protein_id": "ENSP00000483499.1",
"transcript_support_level": 2,
"aa_start": 165,
"aa_end": null,
"aa_length": 286,
"cds_start": 493,
"cds_end": null,
"cds_length": 861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000618001.4"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.460A>G",
"hgvs_p": "p.Thr154Ala",
"transcript": "NM_001278682.2",
"protein_id": "NP_001265611.1",
"transcript_support_level": null,
"aa_start": 154,
"aa_end": null,
"aa_length": 275,
"cds_start": 460,
"cds_end": null,
"cds_length": 828,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001278682.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.451A>G",
"hgvs_p": "p.Thr151Ala",
"transcript": "NM_001278684.2",
"protein_id": "NP_001265613.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 272,
"cds_start": 451,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001278684.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.451A>G",
"hgvs_p": "p.Thr151Ala",
"transcript": "NM_173208.3",
"protein_id": "NP_775300.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 272,
"cds_start": 451,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_173208.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.451A>G",
"hgvs_p": "p.Thr151Ala",
"transcript": "ENST00000407501.6",
"protein_id": "ENSP00000384133.2",
"transcript_support_level": 3,
"aa_start": 151,
"aa_end": null,
"aa_length": 272,
"cds_start": 451,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000407501.6"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.451A>G",
"hgvs_p": "p.Thr151Ala",
"transcript": "ENST00000870197.1",
"protein_id": "ENSP00000540256.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 272,
"cds_start": 451,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870197.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.451A>G",
"hgvs_p": "p.Thr151Ala",
"transcript": "ENST00000870198.1",
"protein_id": "ENSP00000540257.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 272,
"cds_start": 451,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000870198.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.451A>G",
"hgvs_p": "p.Thr151Ala",
"transcript": "ENST00000927544.1",
"protein_id": "ENSP00000597603.1",
"transcript_support_level": null,
"aa_start": 151,
"aa_end": null,
"aa_length": 272,
"cds_start": 451,
"cds_end": null,
"cds_length": 819,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927544.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "NM_001278686.3",
"protein_id": "NP_001265615.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001278686.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "NM_001374396.1",
"protein_id": "NP_001361325.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374396.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "NM_001374397.1",
"protein_id": "NP_001361326.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001374397.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "NM_170695.5",
"protein_id": "NP_733796.3",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_170695.5"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "NM_173209.3",
"protein_id": "NP_775301.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_173209.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "NM_173210.4",
"protein_id": "NP_775302.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_173210.4"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "NM_173211.2",
"protein_id": "NP_775303.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_173211.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "NM_174886.3",
"protein_id": "NP_777480.1",
"transcript_support_level": null,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_174886.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "ENST00000345133.9",
"protein_id": "ENSP00000343969.5",
"transcript_support_level": 3,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000345133.9"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TGIF1",
"gene_hgnc_id": 11776,
"hgvs_c": "c.391A>G",
"hgvs_p": "p.Thr131Ala",
"transcript": "ENST00000400167.6",
"protein_id": "ENSP00000383031.2",
"transcript_support_level": 3,
"aa_start": 131,
"aa_end": null,
"aa_length": 252,
"cds_start": 391,
"cds_end": null,
"cds_length": 759,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000400167.6"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
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}