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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 18-44952641-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=44952641&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "18",
      "pos": 44952641,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "ENST00000649279.2",
      "consequences": [
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile",
          "transcript": "NM_015559.3",
          "protein_id": "NP_056374.2",
          "transcript_support_level": null,
          "aa_start": 1101,
          "aa_end": null,
          "aa_length": 1596,
          "cds_start": 3301,
          "cds_end": null,
          "cds_length": 4791,
          "cdna_start": 3607,
          "cdna_end": null,
          "cdna_length": 9909,
          "mane_select": "ENST00000649279.2",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile",
          "transcript": "ENST00000649279.2",
          "protein_id": "ENSP00000497406.1",
          "transcript_support_level": null,
          "aa_start": 1101,
          "aa_end": null,
          "aa_length": 1596,
          "cds_start": 3301,
          "cds_end": null,
          "cds_length": 4791,
          "cdna_start": 3607,
          "cdna_end": null,
          "cdna_length": 9909,
          "mane_select": "NM_015559.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile",
          "transcript": "NM_001379141.1",
          "protein_id": "NP_001366070.1",
          "transcript_support_level": null,
          "aa_start": 1101,
          "aa_end": null,
          "aa_length": 1596,
          "cds_start": 3301,
          "cds_end": null,
          "cds_length": 4791,
          "cdna_start": 3796,
          "cdna_end": null,
          "cdna_length": 10098,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile",
          "transcript": "NM_001379142.1",
          "protein_id": "NP_001366071.1",
          "transcript_support_level": null,
          "aa_start": 1101,
          "aa_end": null,
          "aa_length": 1596,
          "cds_start": 3301,
          "cds_end": null,
          "cds_length": 4791,
          "cdna_start": 3640,
          "cdna_end": null,
          "cdna_length": 9942,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile",
          "transcript": "ENST00000677068.1",
          "protein_id": "ENSP00000504398.1",
          "transcript_support_level": null,
          "aa_start": 1101,
          "aa_end": null,
          "aa_length": 1596,
          "cds_start": 3301,
          "cds_end": null,
          "cds_length": 4791,
          "cdna_start": 3680,
          "cdna_end": null,
          "cdna_length": 6280,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile",
          "transcript": "ENST00000677077.1",
          "protein_id": "ENSP00000503656.1",
          "transcript_support_level": null,
          "aa_start": 1101,
          "aa_end": null,
          "aa_length": 1596,
          "cds_start": 3301,
          "cds_end": null,
          "cds_length": 4791,
          "cdna_start": 3652,
          "cdna_end": null,
          "cdna_length": 9954,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile",
          "transcript": "ENST00000677130.1",
          "protein_id": "ENSP00000503094.1",
          "transcript_support_level": null,
          "aa_start": 1101,
          "aa_end": null,
          "aa_length": 1596,
          "cds_start": 3301,
          "cds_end": null,
          "cds_length": 4791,
          "cdna_start": 3719,
          "cdna_end": null,
          "cdna_length": 10021,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "I",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile",
          "transcript": "ENST00000678152.1",
          "protein_id": "ENSP00000502995.1",
          "transcript_support_level": null,
          "aa_start": 1101,
          "aa_end": null,
          "aa_length": 1596,
          "cds_start": 3301,
          "cds_end": null,
          "cds_length": 4791,
          "cdna_start": 3547,
          "cdna_end": null,
          "cdna_length": 9849,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile",
          "transcript": "NM_001410862.1",
          "protein_id": "NP_001397791.1",
          "transcript_support_level": null,
          "aa_start": 1101,
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          "cds_start": 3301,
          "cds_end": null,
          "cds_length": 4620,
          "cdna_start": 3607,
          "cdna_end": null,
          "cdna_length": 9738,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
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          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
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          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile",
          "transcript": "ENST00000677699.1",
          "protein_id": "ENSP00000503964.1",
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          "cds_start": 3301,
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          "mane_select": null,
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        {
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          "intron_rank": null,
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          "gene_symbol": "SETBP1",
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          "hgvs_c": "c.3379G>A",
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        {
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          "intron_rank": null,
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          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.2824G>A",
          "hgvs_p": "p.Val942Ile",
          "transcript": "XM_024451157.2",
          "protein_id": "XP_024306925.1",
          "transcript_support_level": null,
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          "aa_length": 1437,
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          "cdna_start": 50487,
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        },
        {
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          "strand": true,
          "consequences": [
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          ],
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          "transcript": "XM_047437479.1",
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          "cds_start": 2824,
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          "cds_length": 4314,
          "cdna_start": 96613,
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          "cdna_length": 102915,
          "mane_select": null,
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          "feature": null
        },
        {
          "aa_ref": "V",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          "exon_rank": 6,
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          "exon_count": 8,
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          "gene_symbol": "SETBP1",
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          "hgvs_c": "c.2824G>A",
          "hgvs_p": "p.Val942Ile",
          "transcript": "XM_047437480.1",
          "protein_id": "XP_047293436.1",
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          "cds_start": 2824,
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          "cdna_start": 91668,
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          "cdna_length": 97970,
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          "feature": null
        },
        {
          "aa_ref": "V",
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          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
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          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.3379G>A",
          "hgvs_p": "p.Val1127Ile",
          "transcript": "XM_024451158.2",
          "protein_id": "XP_024306926.1",
          "transcript_support_level": null,
          "aa_start": 1127,
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          "aa_length": 1422,
          "cds_start": 3379,
          "cds_end": null,
          "cds_length": 4269,
          "cdna_start": 3874,
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          "cdna_length": 31602,
          "mane_select": null,
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        },
        {
          "aa_ref": "V",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
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          "gene_symbol": "SETBP1",
          "gene_hgnc_id": 15573,
          "hgvs_c": "c.2644G>A",
          "hgvs_p": "p.Val882Ile",
          "transcript": "XM_047437481.1",
          "protein_id": "XP_047293437.1",
          "transcript_support_level": null,
          "aa_start": 882,
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          "aa_length": 1377,
          "cds_start": 2644,
          "cds_end": null,
          "cds_length": 4134,
          "cdna_start": 91366,
          "cdna_end": null,
          "cdna_length": 97668,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "SETBP1",
      "gene_hgnc_id": 15573,
      "dbsnp": "rs3744825",
      "frequency_reference_population": 0.12650768,
      "hom_count_reference_population": 14285,
      "allele_count_reference_population": 204149,
      "gnomad_exomes_af": 0.128512,
      "gnomad_genomes_af": 0.107243,
      "gnomad_exomes_ac": 187844,
      "gnomad_genomes_ac": 16305,
      "gnomad_exomes_homalt": 13161,
      "gnomad_genomes_homalt": 1124,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.004114776849746704,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.033,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0742,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.53,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 1.231,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -20,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6_Very_Strong,BA1",
      "acmg_by_gene": [
        {
          "score": -20,
          "benign_score": 20,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6_Very_Strong",
            "BA1"
          ],
          "verdict": "Benign",
          "transcript": "ENST00000649279.2",
          "gene_symbol": "SETBP1",
          "hgnc_id": 15573,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.3301G>A",
          "hgvs_p": "p.Val1101Ile"
        }
      ],
      "clinvar_disease": "Schinzel-Giedion syndrome,not provided,not specified",
      "clinvar_classification": "Benign",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "B:5",
      "phenotype_combined": "not specified|not provided|Schinzel-Giedion syndrome",
      "pathogenicity_classification_combined": "Benign",
      "custom_annotations": null
    }
  ],
  "message": null
}