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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 18-48289046-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=48289046&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "18",
"pos": 48289046,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000590800.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-79+49128T>C",
"hgvs_p": null,
"transcript": "NM_001318841.2",
"protein_id": "NP_001305770.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 619,
"cds_start": -4,
"cds_end": null,
"cds_length": 1860,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4909,
"mane_select": "ENST00000590800.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-79+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000590800.6",
"protein_id": "ENSP00000467877.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 619,
"cds_start": -4,
"cds_end": null,
"cds_length": 1860,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4909,
"mane_select": "NM_001318841.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-308+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000585404.5",
"protein_id": "ENSP00000464724.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 24,
"cds_start": -4,
"cds_end": null,
"cds_length": 75,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 600,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-205-103051T>C",
"hgvs_p": null,
"transcript": "ENST00000586525.5",
"protein_id": "ENSP00000468537.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 24,
"cds_start": -4,
"cds_end": null,
"cds_length": 75,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 347,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-274+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000586743.5",
"protein_id": "ENSP00000466006.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 24,
"cds_start": -4,
"cds_end": null,
"cds_length": 75,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 566,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-338+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000587107.5",
"protein_id": "ENSP00000465760.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 24,
"cds_start": -4,
"cds_end": null,
"cds_length": 75,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 704,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-230+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000588970.5",
"protein_id": "ENSP00000468502.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 24,
"cds_start": -4,
"cds_end": null,
"cds_length": 75,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 596,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-170+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000589077.5",
"protein_id": "ENSP00000467147.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 24,
"cds_start": -4,
"cds_end": null,
"cds_length": 75,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 462,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-359+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000589194.5",
"protein_id": "ENSP00000468019.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 24,
"cds_start": -4,
"cds_end": null,
"cds_length": 75,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 725,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-206+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000590855.5",
"protein_id": "ENSP00000468306.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 24,
"cds_start": -4,
"cds_end": null,
"cds_length": 75,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 572,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-78-103051T>C",
"hgvs_p": null,
"transcript": "ENST00000591279.5",
"protein_id": "ENSP00000465265.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 24,
"cds_start": -4,
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"cds_length": 75,
"cdna_start": null,
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"cdna_length": 518,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-255-103051T>C",
"hgvs_p": null,
"transcript": "ENST00000592387.5",
"protein_id": "ENSP00000465835.1",
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"aa_start": null,
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"cds_start": -4,
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"cds_length": 75,
"cdna_start": null,
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"cdna_length": 397,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-388+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000592656.5",
"protein_id": "ENSP00000468087.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-256+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000588053.5",
"protein_id": "ENSP00000466088.1",
"transcript_support_level": 1,
"aa_start": null,
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"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
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"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-211+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000588149.5",
"protein_id": "ENSP00000468814.1",
"transcript_support_level": 1,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 2,
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"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-206+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000590178.5",
"protein_id": "ENSP00000465160.1",
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},
{
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],
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"exon_count": 4,
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"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-79+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000591405.5",
"protein_id": "ENSP00000467758.1",
"transcript_support_level": 1,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-208+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000588028.1",
"protein_id": "ENSP00000468152.1",
"transcript_support_level": 1,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 565,
"mane_select": null,
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"biotype": null,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-79+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000588566.5",
"protein_id": "ENSP00000467456.1",
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},
{
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],
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"intron_rank": 5,
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"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-343-36748T>C",
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"transcript": "ENST00000589170.5",
"protein_id": "ENSP00000467338.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 2,
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"gene_symbol": "ZBTB7C",
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"hgvs_c": "c.-334+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000590374.5",
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-252+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000591526.5",
"protein_id": "ENSP00000468752.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 14,
"cds_start": -4,
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"cds_length": 45,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 548,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZBTB7C",
"gene_hgnc_id": 31700,
"hgvs_c": "c.-270+49128T>C",
"hgvs_p": null,
"transcript": "ENST00000593159.5",
"protein_id": "ENSP00000465832.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 14,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"cdna_length": 566,
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