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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 18-50984530-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=50984530&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "18",
      "pos": 50984530,
      "ref": "G",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_018696.3",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "NM_018696.3",
          "protein_id": "NP_061166.1",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 1092,
          "cdna_start": 675,
          "cdna_end": null,
          "cdna_length": 2211,
          "mane_select": "ENST00000269466.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_018696.3"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "ENST00000269466.8",
          "protein_id": "ENSP00000269466.3",
          "transcript_support_level": 1,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 1092,
          "cdna_start": 675,
          "cdna_end": null,
          "cdna_length": 2211,
          "mane_select": "NM_018696.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000269466.8"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "ENST00000591429.1",
          "protein_id": "ENSP00000464770.1",
          "transcript_support_level": 1,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 223,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 672,
          "cdna_start": 667,
          "cdna_end": null,
          "cdna_length": 975,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000591429.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000267699",
          "gene_hgnc_id": null,
          "hgvs_c": "n.157+9969G>C",
          "hgvs_p": null,
          "transcript": "ENST00000590722.2",
          "protein_id": "ENSP00000465737.1",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1228,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000590722.2"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "ENST00000858935.1",
          "protein_id": "ENSP00000528994.1",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 1092,
          "cdna_start": 905,
          "cdna_end": null,
          "cdna_length": 1595,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000858935.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "ENST00000858936.1",
          "protein_id": "ENSP00000528995.1",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 1092,
          "cdna_start": 985,
          "cdna_end": null,
          "cdna_length": 1684,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000858936.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "ENST00000858938.1",
          "protein_id": "ENSP00000528997.1",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 1092,
          "cdna_start": 1126,
          "cdna_end": null,
          "cdna_length": 1825,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000858938.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "ENST00000858939.1",
          "protein_id": "ENSP00000528998.1",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 1092,
          "cdna_start": 1254,
          "cdna_end": null,
          "cdna_length": 1953,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000858939.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "ENST00000961942.1",
          "protein_id": "ENSP00000632001.1",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 1092,
          "cdna_start": 1331,
          "cdna_end": null,
          "cdna_length": 2022,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000961942.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "ENST00000961943.1",
          "protein_id": "ENSP00000632002.1",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 1092,
          "cdna_start": 693,
          "cdna_end": null,
          "cdna_length": 1384,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000961943.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "ENST00000961944.1",
          "protein_id": "ENSP00000632003.1",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 1092,
          "cdna_start": 693,
          "cdna_end": null,
          "cdna_length": 3099,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000961944.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.178G>C",
          "hgvs_p": "p.Gly60Arg",
          "transcript": "ENST00000917712.1",
          "protein_id": "ENSP00000587771.1",
          "transcript_support_level": null,
          "aa_start": 60,
          "aa_end": null,
          "aa_length": 225,
          "cds_start": 178,
          "cds_end": null,
          "cds_length": 678,
          "cdna_start": 274,
          "cdna_end": null,
          "cdna_length": 973,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000917712.1"
        },
        {
          "aa_ref": "Q",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.201G>C",
          "hgvs_p": "p.Gln67His",
          "transcript": "ENST00000588577.5",
          "protein_id": "ENSP00000467389.1",
          "transcript_support_level": 2,
          "aa_start": 67,
          "aa_end": null,
          "aa_length": 88,
          "cds_start": 201,
          "cds_end": null,
          "cds_length": 267,
          "cdna_start": 333,
          "cdna_end": null,
          "cdna_length": 694,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000588577.5"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg",
          "transcript": "ENST00000858940.1",
          "protein_id": "ENSP00000528999.1",
          "transcript_support_level": null,
          "aa_start": 198,
          "aa_end": null,
          "aa_length": 352,
          "cds_start": 592,
          "cds_end": null,
          "cds_length": 1059,
          "cdna_start": 665,
          "cdna_end": null,
          "cdna_length": 1331,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000858940.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.158-2089G>C",
          "hgvs_p": null,
          "transcript": "ENST00000858937.1",
          "protein_id": "ENSP00000528996.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 207,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 624,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 914,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000858937.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": 3,
          "intron_rank_end": null,
          "gene_symbol": "ELAC1",
          "gene_hgnc_id": 14197,
          "hgvs_c": "c.158-2089G>C",
          "hgvs_p": null,
          "transcript": "ENST00000858941.1",
          "protein_id": "ENSP00000529000.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 207,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 624,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1165,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000858941.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000267699",
          "gene_hgnc_id": null,
          "hgvs_c": "n.301G>C",
          "hgvs_p": null,
          "transcript": "ENST00000588256.1",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 526,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000588256.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000289868",
          "gene_hgnc_id": null,
          "hgvs_c": "n.279C>G",
          "hgvs_p": null,
          "transcript": "ENST00000797255.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 729,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000797255.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000289868",
          "gene_hgnc_id": null,
          "hgvs_c": "n.163-10019C>G",
          "hgvs_p": null,
          "transcript": "ENST00000797254.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 373,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000797254.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000289868",
          "gene_hgnc_id": null,
          "hgvs_c": "n.320-190C>G",
          "hgvs_p": null,
          "transcript": "ENST00000797256.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 680,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000797256.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
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        {
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        {
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          "feature": "XR_007066371.1"
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      ],
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      "dbsnp": "rs751258412",
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      "computational_prediction_selected": "Pathogenic",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.019999999552965164,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "revel_prediction": "Uncertain_significance",
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      "alphamissense_prediction": null,
      "bayesdelnoaf_score": 0.19,
      "bayesdelnoaf_prediction": "Pathogenic",
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      "spliceai_max_score": 0.02,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
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      "apogee2_prediction": null,
      "mitotip_score": null,
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      "acmg_score": 3,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,PP3",
      "acmg_by_gene": [
        {
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          "benign_score": 0,
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          "criteria": [
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            "PP3"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_018696.3",
          "gene_symbol": "ELAC1",
          "hgnc_id": 14197,
          "effects": [
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          "inheritance_mode": "AR",
          "hgvs_c": "c.592G>C",
          "hgvs_p": "p.Gly198Arg"
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        {
          "score": 3,
          "benign_score": 0,
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          "criteria": [
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            "PP3"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000590722.2",
          "gene_symbol": "ENSG00000267699",
          "hgnc_id": null,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.157+9969G>C",
          "hgvs_p": null
        },
        {
          "score": 3,
          "benign_score": 0,
          "pathogenic_score": 3,
          "criteria": [
            "PM2",
            "PP3"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000797255.1",
          "gene_symbol": "ENSG00000289868",
          "hgnc_id": null,
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.279C>G",
          "hgvs_p": null
        },
        {
          "score": 3,
          "benign_score": 0,
          "pathogenic_score": 3,
          "criteria": [
            "PM2",
            "PP3"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "XR_001753449.3",
          "gene_symbol": "LOC107985152",
          "hgnc_id": null,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.10155-190C>G",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.