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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 18-58052988-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=58052988&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "18",
      "pos": 58052988,
      "ref": "C",
      "alt": "T",
      "effect": "intron_variant",
      "transcript": "ENST00000400345.8",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.48+8280C>T",
          "hgvs_p": null,
          "transcript": "NM_001144967.3",
          "protein_id": "NP_001138439.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 975,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2928,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8633,
          "mane_select": "ENST00000400345.8",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.48+8280C>T",
          "hgvs_p": null,
          "transcript": "ENST00000400345.8",
          "protein_id": "ENSP00000383199.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 975,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2928,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8633,
          "mane_select": "NM_001144967.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.48+8280C>T",
          "hgvs_p": null,
          "transcript": "ENST00000382850.8",
          "protein_id": "ENSP00000372301.3",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 955,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2868,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8251,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 29,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.48+8280C>T",
          "hgvs_p": null,
          "transcript": "ENST00000356462.10",
          "protein_id": "ENSP00000348847.5",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 911,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2736,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3335,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.-316+5478C>T",
          "hgvs_p": null,
          "transcript": "ENST00000456986.5",
          "protein_id": "ENSP00000411947.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 854,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2565,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8436,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "n.25+7298C>T",
          "hgvs_p": null,
          "transcript": "ENST00000585594.6",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3657,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "n.92+7200C>T",
          "hgvs_p": null,
          "transcript": "ENST00000591579.5",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 144,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.48+8280C>T",
          "hgvs_p": null,
          "transcript": "NM_015277.6",
          "protein_id": "NP_056092.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 955,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2868,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 8573,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.-623-1239C>T",
          "hgvs_p": null,
          "transcript": "ENST00000675147.1",
          "protein_id": "ENSP00000501840.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 948,
          "cds_start": -4,
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          "cds_length": 2847,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5380,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.9+7298C>T",
          "hgvs_p": null,
          "transcript": "ENST00000676223.1",
          "protein_id": "ENSP00000502361.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 942,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2829,
          "cdna_start": null,
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          "cdna_length": 4739,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
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          "canonical": false,
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          "strand": true,
          "consequences": [
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          "exon_rank": null,
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          "exon_count": 29,
          "intron_rank": 1,
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          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.48+8280C>T",
          "hgvs_p": null,
          "transcript": "NM_001243960.2",
          "protein_id": "NP_001230889.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 911,
          "cds_start": -4,
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          "cds_length": 2736,
          "cdna_start": null,
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          "cdna_length": 8441,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          "exon_rank": null,
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          "exon_count": 28,
          "intron_rank": 1,
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          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.48+8280C>T",
          "hgvs_p": null,
          "transcript": "ENST00000256830.13",
          "protein_id": "ENSP00000256830.8",
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        {
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          "intron_rank": 1,
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          "gene_symbol": "NEDD4L",
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          "hgvs_c": "c.48+8280C>T",
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        {
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          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
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          "hgvs_p": null,
          "transcript": "NM_001144964.1",
          "protein_id": "NP_001138436.1",
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        {
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          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "c.48+8280C>T",
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          "transcript": "ENST00000589054.5",
          "protein_id": "ENSP00000465669.1",
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        {
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          "intron_rank": 1,
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          "gene_symbol": "NEDD4L",
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          "hgvs_c": "c.-371+7200C>T",
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          "transcript": "ENST00000592846.5",
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        {
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          "gene_symbol": "NEDD4L",
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          "hgvs_c": "n.85+6970C>T",
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          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
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          "cdna_length": 165,
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        },
        {
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          "protein_coding": false,
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          ],
          "exon_rank": null,
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          "exon_count": 3,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "NEDD4L",
          "gene_hgnc_id": 7728,
          "hgvs_c": "n.100+7200C>T",
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          "transcript": "ENST00000591989.5",
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