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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 18-58366201-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=58366201&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "18",
"pos": 58366201,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001437337.1",
"consequences": [
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.2036A>G",
"hgvs_p": "p.Tyr679Cys",
"transcript": "NM_001144967.3",
"protein_id": "NP_001138439.1",
"transcript_support_level": null,
"aa_start": 679,
"aa_end": null,
"aa_length": 975,
"cds_start": 2036,
"cds_end": null,
"cds_length": 2928,
"cdna_start": 2471,
"cdna_end": null,
"cdna_length": 8633,
"mane_select": "ENST00000400345.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001144967.3"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.2036A>G",
"hgvs_p": "p.Tyr679Cys",
"transcript": "ENST00000400345.8",
"protein_id": "ENSP00000383199.2",
"transcript_support_level": 1,
"aa_start": 679,
"aa_end": null,
"aa_length": 975,
"cds_start": 2036,
"cds_end": null,
"cds_length": 2928,
"cdna_start": 2471,
"cdna_end": null,
"cdna_length": 8633,
"mane_select": "NM_001144967.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000400345.8"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.2012A>G",
"hgvs_p": "p.Tyr671Cys",
"transcript": "ENST00000357895.9",
"protein_id": "ENSP00000350569.4",
"transcript_support_level": 1,
"aa_start": 671,
"aa_end": null,
"aa_length": 967,
"cds_start": 2012,
"cds_end": null,
"cds_length": 2904,
"cdna_start": 2215,
"cdna_end": null,
"cdna_length": 3543,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000357895.9"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1976A>G",
"hgvs_p": "p.Tyr659Cys",
"transcript": "ENST00000382850.8",
"protein_id": "ENSP00000372301.3",
"transcript_support_level": 1,
"aa_start": 659,
"aa_end": null,
"aa_length": 955,
"cds_start": 1976,
"cds_end": null,
"cds_length": 2868,
"cdna_start": 2089,
"cdna_end": null,
"cdna_length": 8251,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000382850.8"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1952A>G",
"hgvs_p": "p.Tyr651Cys",
"transcript": "ENST00000586263.5",
"protein_id": "ENSP00000468546.1",
"transcript_support_level": 1,
"aa_start": 651,
"aa_end": null,
"aa_length": 947,
"cds_start": 1952,
"cds_end": null,
"cds_length": 2844,
"cdna_start": 2151,
"cdna_end": null,
"cdna_length": 3347,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000586263.5"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1844A>G",
"hgvs_p": "p.Tyr615Cys",
"transcript": "ENST00000356462.10",
"protein_id": "ENSP00000348847.5",
"transcript_support_level": 1,
"aa_start": 615,
"aa_end": null,
"aa_length": 911,
"cds_start": 1844,
"cds_end": null,
"cds_length": 2736,
"cdna_start": 2138,
"cdna_end": null,
"cdna_length": 3335,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000356462.10"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1673A>G",
"hgvs_p": "p.Tyr558Cys",
"transcript": "ENST00000431212.6",
"protein_id": "ENSP00000389406.1",
"transcript_support_level": 1,
"aa_start": 558,
"aa_end": null,
"aa_length": 854,
"cds_start": 1673,
"cds_end": null,
"cds_length": 2565,
"cdna_start": 2137,
"cdna_end": null,
"cdna_length": 3338,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000431212.6"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1673A>G",
"hgvs_p": "p.Tyr558Cys",
"transcript": "ENST00000456986.5",
"protein_id": "ENSP00000411947.1",
"transcript_support_level": 1,
"aa_start": 558,
"aa_end": null,
"aa_length": 854,
"cds_start": 1673,
"cds_end": null,
"cds_length": 2565,
"cdna_start": 2273,
"cdna_end": null,
"cdna_length": 8436,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000456986.5"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1613A>G",
"hgvs_p": "p.Tyr538Cys",
"transcript": "ENST00000435432.6",
"protein_id": "ENSP00000393395.1",
"transcript_support_level": 1,
"aa_start": 538,
"aa_end": null,
"aa_length": 834,
"cds_start": 1613,
"cds_end": null,
"cds_length": 2505,
"cdna_start": 2243,
"cdna_end": null,
"cdna_length": 3417,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000435432.6"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1613A>G",
"hgvs_p": "p.Tyr538Cys",
"transcript": "ENST00000456173.6",
"protein_id": "ENSP00000405440.1",
"transcript_support_level": 1,
"aa_start": 538,
"aa_end": null,
"aa_length": 834,
"cds_start": 1613,
"cds_end": null,
"cds_length": 2505,
"cdna_start": 2198,
"cdna_end": null,
"cdna_length": 4978,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000456173.6"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.2873A>G",
"hgvs_p": "p.Tyr958Cys",
"transcript": "NM_001437337.1",
"protein_id": "NP_001424266.1",
"transcript_support_level": null,
"aa_start": 958,
"aa_end": null,
"aa_length": 1254,
"cds_start": 2873,
"cds_end": null,
"cds_length": 3765,
"cdna_start": 2998,
"cdna_end": null,
"cdna_length": 9160,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001437337.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.2873A>G",
"hgvs_p": "p.Tyr958Cys",
"transcript": "ENST00000635997.1",
"protein_id": "ENSP00000490696.1",
"transcript_support_level": 5,
"aa_start": 958,
"aa_end": null,
"aa_length": 1254,
"cds_start": 2873,
"cds_end": null,
"cds_length": 3765,
"cdna_start": 3074,
"cdna_end": null,
"cdna_length": 4402,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000635997.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.2012A>G",
"hgvs_p": "p.Tyr671Cys",
"transcript": "NM_001144968.2",
"protein_id": "NP_001138440.1",
"transcript_support_level": null,
"aa_start": 671,
"aa_end": null,
"aa_length": 967,
"cds_start": 2012,
"cds_end": null,
"cds_length": 2904,
"cdna_start": 2228,
"cdna_end": null,
"cdna_length": 8390,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001144968.2"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1976A>G",
"hgvs_p": "p.Tyr659Cys",
"transcript": "NM_015277.6",
"protein_id": "NP_056092.2",
"transcript_support_level": null,
"aa_start": 659,
"aa_end": null,
"aa_length": 955,
"cds_start": 1976,
"cds_end": null,
"cds_length": 2868,
"cdna_start": 2411,
"cdna_end": null,
"cdna_length": 8573,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015277.6"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1955A>G",
"hgvs_p": "p.Tyr652Cys",
"transcript": "ENST00000675147.1",
"protein_id": "ENSP00000501840.1",
"transcript_support_level": null,
"aa_start": 652,
"aa_end": null,
"aa_length": 948,
"cds_start": 1955,
"cds_end": null,
"cds_length": 2847,
"cdna_start": 2603,
"cdna_end": null,
"cdna_length": 5380,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000675147.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1952A>G",
"hgvs_p": "p.Tyr651Cys",
"transcript": "NM_001144969.2",
"protein_id": "NP_001138441.1",
"transcript_support_level": null,
"aa_start": 651,
"aa_end": null,
"aa_length": 947,
"cds_start": 1952,
"cds_end": null,
"cds_length": 2844,
"cdna_start": 2168,
"cdna_end": null,
"cdna_length": 8330,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001144969.2"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1937A>G",
"hgvs_p": "p.Tyr646Cys",
"transcript": "ENST00000676223.1",
"protein_id": "ENSP00000502361.1",
"transcript_support_level": null,
"aa_start": 646,
"aa_end": null,
"aa_length": 942,
"cds_start": 1937,
"cds_end": null,
"cds_length": 2829,
"cdna_start": 1962,
"cdna_end": null,
"cdna_length": 4739,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000676223.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1901A>G",
"hgvs_p": "p.Tyr634Cys",
"transcript": "ENST00000675221.1",
"protein_id": "ENSP00000502761.1",
"transcript_support_level": null,
"aa_start": 634,
"aa_end": null,
"aa_length": 930,
"cds_start": 1901,
"cds_end": null,
"cds_length": 2793,
"cdna_start": 2007,
"cdna_end": null,
"cdna_length": 4784,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000675221.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1844A>G",
"hgvs_p": "p.Tyr615Cys",
"transcript": "NM_001243960.2",
"protein_id": "NP_001230889.1",
"transcript_support_level": null,
"aa_start": 615,
"aa_end": null,
"aa_length": 911,
"cds_start": 1844,
"cds_end": null,
"cds_length": 2736,
"cdna_start": 2279,
"cdna_end": null,
"cdna_length": 8441,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001243960.2"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1778A>G",
"hgvs_p": "p.Tyr593Cys",
"transcript": "ENST00000936802.1",
"protein_id": "ENSP00000606861.1",
"transcript_support_level": null,
"aa_start": 593,
"aa_end": null,
"aa_length": 889,
"cds_start": 1778,
"cds_end": null,
"cds_length": 2670,
"cdna_start": 2389,
"cdna_end": null,
"cdna_length": 5201,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936802.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1724A>G",
"hgvs_p": "p.Tyr575Cys",
"transcript": "ENST00000256830.13",
"protein_id": "ENSP00000256830.8",
"transcript_support_level": 5,
"aa_start": 575,
"aa_end": null,
"aa_length": 871,
"cds_start": 1724,
"cds_end": null,
"cds_length": 2616,
"cdna_start": 1724,
"cdna_end": null,
"cdna_length": 2920,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000256830.13"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEDD4L",
"gene_hgnc_id": 7728,
"hgvs_c": "c.1700A>G",
"hgvs_p": "p.Tyr567Cys",
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"clinvar_review_status": "no assertion criteria provided",
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}
],
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}