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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 18-58390667-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=58390667&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PS3",
            "PM2",
            "PP3_Moderate",
            "PP5_Very_Strong"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "NEDD4L",
          "hgnc_id": 7728,
          "hgvs_c": "c.3514G>A",
          "hgvs_p": "p.Glu1172Lys",
          "inheritance_mode": "AD",
          "pathogenic_score": 16,
          "score": 16,
          "transcript": "NM_001437337.1",
          "verdict": "Pathogenic"
        }
      ],
      "acmg_classification": "Pathogenic",
      "acmg_criteria": "PS3,PM2,PP3_Moderate,PP5_Very_Strong",
      "acmg_score": 16,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.9941,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Pathogenic",
      "bayesdelnoaf_score": 0.19,
      "chr": "18",
      "clinvar_classification": "Pathogenic/Likely pathogenic",
      "clinvar_disease": " cleft palate and developmental delay, distal,Chromosome 5Q14.3 deletion syndrome,Periventricular nodular heterotopia 7,Periventricular nodular heterotopia with syndactyly,not provided",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "P:5 LP:1",
      "computational_prediction_selected": "Pathogenic",
      "computational_score_selected": 0.8832600116729736,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 975,
          "aa_ref": "E",
          "aa_start": 893,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8633,
          "cdna_start": 3112,
          "cds_end": null,
          "cds_length": 2928,
          "cds_start": 2677,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "NM_001144967.3",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2677G>A",
          "hgvs_p": "p.Glu893Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000400345.8",
          "protein_coding": true,
          "protein_id": "NP_001138439.1",
          "strand": true,
          "transcript": "NM_001144967.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 975,
          "aa_ref": "E",
          "aa_start": 893,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 8633,
          "cdna_start": 3112,
          "cds_end": null,
          "cds_length": 2928,
          "cds_start": 2677,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000400345.8",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2677G>A",
          "hgvs_p": "p.Glu893Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001144967.3",
          "protein_coding": true,
          "protein_id": "ENSP00000383199.2",
          "strand": true,
          "transcript": "ENST00000400345.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 967,
          "aa_ref": "E",
          "aa_start": 885,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3543,
          "cdna_start": 2856,
          "cds_end": null,
          "cds_length": 2904,
          "cds_start": 2653,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000357895.9",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2653G>A",
          "hgvs_p": "p.Glu885Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000350569.4",
          "strand": true,
          "transcript": "ENST00000357895.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 955,
          "aa_ref": "E",
          "aa_start": 873,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8251,
          "cdna_start": 2730,
          "cds_end": null,
          "cds_length": 2868,
          "cds_start": 2617,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 30,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000382850.8",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2617G>A",
          "hgvs_p": "p.Glu873Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000372301.3",
          "strand": true,
          "transcript": "ENST00000382850.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 947,
          "aa_ref": "E",
          "aa_start": 865,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3347,
          "cdna_start": 2792,
          "cds_end": null,
          "cds_length": 2844,
          "cds_start": 2593,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 30,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000586263.5",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2593G>A",
          "hgvs_p": "p.Glu865Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000468546.1",
          "strand": true,
          "transcript": "ENST00000586263.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "E",
          "aa_start": 829,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3335,
          "cdna_start": 2779,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2485,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 29,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000356462.10",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2485G>A",
          "hgvs_p": "p.Glu829Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000348847.5",
          "strand": true,
          "transcript": "ENST00000356462.10",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 854,
          "aa_ref": "E",
          "aa_start": 772,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3338,
          "cdna_start": 2778,
          "cds_end": null,
          "cds_length": 2565,
          "cds_start": 2314,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 30,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000431212.6",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2314G>A",
          "hgvs_p": "p.Glu772Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000389406.1",
          "strand": true,
          "transcript": "ENST00000431212.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 854,
          "aa_ref": "E",
          "aa_start": 772,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8436,
          "cdna_start": 2914,
          "cds_end": null,
          "cds_length": 2565,
          "cds_start": 2314,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000456986.5",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2314G>A",
          "hgvs_p": "p.Glu772Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000411947.1",
          "strand": true,
          "transcript": "ENST00000456986.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 834,
          "aa_ref": "E",
          "aa_start": 752,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3417,
          "cdna_start": 2884,
          "cds_end": null,
          "cds_length": 2505,
          "cds_start": 2254,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000435432.6",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2254G>A",
          "hgvs_p": "p.Glu752Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000393395.1",
          "strand": true,
          "transcript": "ENST00000435432.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 834,
          "aa_ref": "E",
          "aa_start": 752,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4978,
          "cdna_start": 2839,
          "cds_end": null,
          "cds_length": 2505,
          "cds_start": 2254,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 29,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000456173.6",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2254G>A",
          "hgvs_p": "p.Glu752Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000405440.1",
          "strand": true,
          "transcript": "ENST00000456173.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 1254,
          "aa_ref": "E",
          "aa_start": 1172,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 9160,
          "cdna_start": 3639,
          "cds_end": null,
          "cds_length": 3765,
          "cds_start": 3514,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "NM_001437337.1",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.3514G>A",
          "hgvs_p": "p.Glu1172Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001424266.1",
          "strand": true,
          "transcript": "NM_001437337.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 1254,
          "aa_ref": "E",
          "aa_start": 1172,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4402,
          "cdna_start": 3715,
          "cds_end": null,
          "cds_length": 3765,
          "cds_start": 3514,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": 25,
          "exon_rank_end": null,
          "feature": "ENST00000635997.1",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.3514G>A",
          "hgvs_p": "p.Glu1172Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000490696.1",
          "strand": true,
          "transcript": "ENST00000635997.1",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 967,
          "aa_ref": "E",
          "aa_start": 885,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8390,
          "cdna_start": 2869,
          "cds_end": null,
          "cds_length": 2904,
          "cds_start": 2653,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "NM_001144968.2",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2653G>A",
          "hgvs_p": "p.Glu885Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001138440.1",
          "strand": true,
          "transcript": "NM_001144968.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 955,
          "aa_ref": "E",
          "aa_start": 873,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8573,
          "cdna_start": 3052,
          "cds_end": null,
          "cds_length": 2868,
          "cds_start": 2617,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 30,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "NM_015277.6",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2617G>A",
          "hgvs_p": "p.Glu873Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_056092.2",
          "strand": true,
          "transcript": "NM_015277.6",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 948,
          "aa_ref": "E",
          "aa_start": 866,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5380,
          "cdna_start": 3244,
          "cds_end": null,
          "cds_length": 2847,
          "cds_start": 2596,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 31,
          "exon_rank": 29,
          "exon_rank_end": null,
          "feature": "ENST00000675147.1",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2596G>A",
          "hgvs_p": "p.Glu866Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000501840.1",
          "strand": true,
          "transcript": "ENST00000675147.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 947,
          "aa_ref": "E",
          "aa_start": 865,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8330,
          "cdna_start": 2809,
          "cds_end": null,
          "cds_length": 2844,
          "cds_start": 2593,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 30,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "NM_001144969.2",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2593G>A",
          "hgvs_p": "p.Glu865Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001138441.1",
          "strand": true,
          "transcript": "NM_001144969.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 942,
          "aa_ref": "E",
          "aa_start": 860,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4739,
          "cdna_start": 2603,
          "cds_end": null,
          "cds_length": 2829,
          "cds_start": 2578,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 30,
          "exon_rank": 28,
          "exon_rank_end": null,
          "feature": "ENST00000676223.1",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2578G>A",
          "hgvs_p": "p.Glu860Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000502361.1",
          "strand": true,
          "transcript": "ENST00000676223.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 930,
          "aa_ref": "E",
          "aa_start": 848,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4784,
          "cdna_start": 2648,
          "cds_end": null,
          "cds_length": 2793,
          "cds_start": 2542,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 29,
          "exon_rank": 27,
          "exon_rank_end": null,
          "feature": "ENST00000675221.1",
          "gene_hgnc_id": 7728,
          "gene_symbol": "NEDD4L",
          "hgvs_c": "c.2542G>A",
          "hgvs_p": "p.Glu848Lys",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000502761.1",
          "strand": true,
          "transcript": "ENST00000675221.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "K",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "E",
          "aa_start": 829,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 8441,
          "cdna_start": 2920,
          "cds_end": null,
          "cds_length": 2736,
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  ]
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.