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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 18-58918708-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=58918708&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "18",
"pos": 58918708,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_018181.6",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "NM_001375912.1",
"protein_id": "NP_001362841.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000591808.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001375912.1"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000591808.6",
"protein_id": "ENSP00000468238.1",
"transcript_support_level": 1,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001375912.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000591808.6"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000336078.8",
"protein_id": "ENSP00000338217.4",
"transcript_support_level": 1,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000336078.8"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000591083.5",
"protein_id": "ENSP00000468532.1",
"transcript_support_level": 1,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000591083.5"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000591230.5",
"protein_id": "ENSP00000465709.1",
"transcript_support_level": 1,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000591230.5"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "NM_001318726.2",
"protein_id": "NP_001305655.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001318726.2"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "NM_001318727.2",
"protein_id": "NP_001305656.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001318727.2"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "NM_001318728.2",
"protein_id": "NP_001305657.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001318728.2"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "NM_001353525.2",
"protein_id": "NP_001340454.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353525.2"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "NM_001353526.2",
"protein_id": "NP_001340455.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353526.2"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "NM_001353527.2",
"protein_id": "NP_001340456.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353527.2"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "NM_001353528.2",
"protein_id": "NP_001340457.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353528.2"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "NM_001353529.2",
"protein_id": "NP_001340458.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001353529.2"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "NM_018181.6",
"protein_id": "NP_060651.2",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018181.6"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000589288.5",
"protein_id": "ENSP00000466007.1",
"transcript_support_level": 5,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000589288.5"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000929496.1",
"protein_id": "ENSP00000599555.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929496.1"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000929498.1",
"protein_id": "ENSP00000599557.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929498.1"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000929499.1",
"protein_id": "ENSP00000599558.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929499.1"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000929500.1",
"protein_id": "ENSP00000599559.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929500.1"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000929501.1",
"protein_id": "ENSP00000599560.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929501.1"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000929503.1",
"protein_id": "ENSP00000599562.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929503.1"
},
{
"aa_ref": "D",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF532",
"gene_hgnc_id": 30940,
"hgvs_c": "c.421G>T",
"hgvs_p": "p.Asp141Tyr",
"transcript": "ENST00000929504.1",
"protein_id": "ENSP00000599563.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 1301,
"cds_start": 421,
"cds_end": null,
"cds_length": 3906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}