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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 18-76378900-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=18&pos=76378900&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "18",
"pos": 76378900,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_014643.4",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "NM_014643.4",
"protein_id": "NP_055458.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3584,
"cdna_end": null,
"cdna_length": 8678,
"mane_select": "ENST00000443185.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014643.4"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "ENST00000443185.7",
"protein_id": "ENSP00000394757.2",
"transcript_support_level": 1,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3584,
"cdna_end": null,
"cdna_length": 8678,
"mane_select": "NM_014643.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000443185.7"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.1384C>T",
"hgvs_p": "p.Leu462Phe",
"transcript": "ENST00000617840.1",
"protein_id": "ENSP00000478712.1",
"transcript_support_level": 1,
"aa_start": 462,
"aa_end": null,
"aa_length": 516,
"cds_start": 1384,
"cds_end": null,
"cds_length": 1551,
"cdna_start": 1386,
"cdna_end": null,
"cdna_length": 2326,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000617840.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "ENST00000871208.1",
"protein_id": "ENSP00000541267.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3450,
"cdna_end": null,
"cdna_length": 3969,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871208.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "ENST00000871209.1",
"protein_id": "ENSP00000541268.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3438,
"cdna_end": null,
"cdna_length": 5215,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871209.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "ENST00000871210.1",
"protein_id": "ENSP00000541269.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3550,
"cdna_end": null,
"cdna_length": 4050,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000871210.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "ENST00000915360.1",
"protein_id": "ENSP00000585419.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3531,
"cdna_end": null,
"cdna_length": 8130,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915360.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "ENST00000915361.1",
"protein_id": "ENSP00000585420.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3578,
"cdna_end": null,
"cdna_length": 6464,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915361.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "ENST00000915362.1",
"protein_id": "ENSP00000585421.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3442,
"cdna_end": null,
"cdna_length": 8025,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915362.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "ENST00000957637.1",
"protein_id": "ENSP00000627696.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3470,
"cdna_end": null,
"cdna_length": 6577,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957637.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "ENST00000957638.1",
"protein_id": "ENSP00000627697.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 4144,
"cdna_end": null,
"cdna_length": 4646,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957638.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "ENST00000957639.1",
"protein_id": "ENSP00000627698.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3664,
"cdna_end": null,
"cdna_length": 6162,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957639.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.13C>T",
"hgvs_p": "p.Leu5Phe",
"transcript": "ENST00000542818.1",
"protein_id": "ENSP00000445902.1",
"transcript_support_level": 2,
"aa_start": 5,
"aa_end": null,
"aa_length": 24,
"cds_start": 13,
"cds_end": null,
"cds_length": 75,
"cdna_start": 14,
"cdna_end": null,
"cdna_length": 346,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000542818.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "XM_011526269.3",
"protein_id": "XP_011524571.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3438,
"cdna_end": null,
"cdna_length": 8532,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011526269.3"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "XM_011526270.4",
"protein_id": "XP_011524572.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3795,
"cdna_end": null,
"cdna_length": 8889,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011526270.4"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "XM_011526273.4",
"protein_id": "XP_011524575.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3470,
"cdna_end": null,
"cdna_length": 8564,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011526273.4"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "XM_011526274.4",
"protein_id": "XP_011524576.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3485,
"cdna_end": null,
"cdna_length": 8579,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011526274.4"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "XM_011526275.3",
"protein_id": "XP_011524577.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
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"cdna_start": 4380,
"cdna_end": null,
"cdna_length": 9474,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011526275.3"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "XM_017026097.3",
"protein_id": "XP_016881586.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 3599,
"cdna_end": null,
"cdna_length": 8693,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017026097.3"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "XM_047437950.1",
"protein_id": "XP_047293906.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 33831,
"cdna_end": null,
"cdna_length": 38925,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047437950.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
"transcript": "XM_047437951.1",
"protein_id": "XP_047293907.1",
"transcript_support_level": null,
"aa_start": 1072,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3214,
"cds_end": null,
"cds_length": 3492,
"cdna_start": 7508,
"cdna_end": null,
"cdna_length": 12602,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047437951.1"
},
{
"aa_ref": "L",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF516",
"gene_hgnc_id": 28990,
"hgvs_c": "c.3214C>T",
"hgvs_p": "p.Leu1072Phe",
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}
],
"message": null
}