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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-10133649-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=10133649&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 10133649,
"ref": "G",
"alt": "T",
"effect": "3_prime_UTR_variant",
"transcript": "NM_001130823.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 41,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.*4607C>A",
"hgvs_p": null,
"transcript": "ENST00000592705.5",
"protein_id": "ENSP00000466657.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5215,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 41,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "c.*18C>A",
"hgvs_p": null,
"transcript": "NM_001130823.3",
"protein_id": "NP_001124295.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1632,
"cds_start": -4,
"cds_end": null,
"cds_length": 4899,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5274,
"mane_select": "ENST00000359526.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 41,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "c.*18C>A",
"hgvs_p": null,
"transcript": "ENST00000359526.9",
"protein_id": "ENSP00000352516.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1632,
"cds_start": -4,
"cds_end": null,
"cds_length": 4899,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5274,
"mane_select": "NM_001130823.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "c.*18C>A",
"hgvs_p": null,
"transcript": "ENST00000340748.8",
"protein_id": "ENSP00000345739.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1616,
"cds_start": -4,
"cds_end": null,
"cds_length": 4851,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5408,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 41,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.*4607C>A",
"hgvs_p": null,
"transcript": "ENST00000592705.5",
"protein_id": "ENSP00000466657.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5215,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.2790C>A",
"hgvs_p": null,
"transcript": "ENST00000586588.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3094,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.2952C>A",
"hgvs_p": null,
"transcript": "ENST00000586667.2",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3259,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.*324C>A",
"hgvs_p": null,
"transcript": "ENST00000588913.5",
"protein_id": "ENSP00000467125.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1775,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.4103C>A",
"hgvs_p": null,
"transcript": "ENST00000589351.6",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4395,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.223C>A",
"hgvs_p": null,
"transcript": "ENST00000591798.5",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 521,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 37,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.4529C>A",
"hgvs_p": null,
"transcript": "ENST00000676604.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 4821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
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"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.5763C>A",
"hgvs_p": null,
"transcript": "ENST00000676820.1",
"protein_id": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.5553C>A",
"hgvs_p": null,
"transcript": "ENST00000676868.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"cdna_length": 5845,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
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"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.*4559C>A",
"hgvs_p": null,
"transcript": "ENST00000677013.1",
"protein_id": "ENSP00000503135.1",
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},
{
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"protein_coding": false,
"strand": false,
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"non_coding_transcript_exon_variant"
],
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"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.1465C>A",
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"transcript": "ENST00000677038.1",
"protein_id": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.398C>A",
"hgvs_p": null,
"transcript": "ENST00000677135.1",
"protein_id": null,
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},
{
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"strand": false,
"consequences": [
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],
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"intron_rank": null,
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"gene_symbol": "DNMT1",
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"hgvs_c": "n.*3989C>A",
"hgvs_p": null,
"transcript": "ENST00000677250.1",
"protein_id": "ENSP00000502894.1",
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
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"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.*1139C>A",
"hgvs_p": null,
"transcript": "ENST00000677616.1",
"protein_id": "ENSP00000503055.1",
"transcript_support_level": null,
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"mane_select": null,
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},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
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"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.*1472C>A",
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"transcript": "ENST00000677634.1",
"protein_id": "ENSP00000504246.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 39,
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"intron_rank": null,
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"gene_symbol": "DNMT1",
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"hgvs_c": "n.*4094C>A",
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"transcript": "ENST00000677685.1",
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},
{
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"consequences": [
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],
"exon_rank": 29,
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"exon_count": 29,
"intron_rank": null,
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"gene_symbol": "DNMT1",
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"hgvs_c": "n.6177C>A",
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 35,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.5850C>A",
"hgvs_p": null,
"transcript": "ENST00000678024.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DNMT1",
"gene_hgnc_id": 2976,
"hgvs_c": "n.1912C>A",
"hgvs_p": null,
"transcript": "ENST00000678107.1",
"protein_id": null,
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"aa_start": null,
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"feature": null
},
{
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