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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-1085691-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=1085691&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 1085691,
"ref": "G",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_001258328.4",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3096G>C",
"hgvs_p": "p.Ser1032Ser",
"transcript": "NM_012292.5",
"protein_id": "NP_036424.2",
"transcript_support_level": null,
"aa_start": 1032,
"aa_end": null,
"aa_length": 1136,
"cds_start": 3096,
"cds_end": null,
"cds_length": 3411,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000313093.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_012292.5"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3096G>C",
"hgvs_p": "p.Ser1032Ser",
"transcript": "ENST00000313093.7",
"protein_id": "ENSP00000316772.2",
"transcript_support_level": 1,
"aa_start": 1032,
"aa_end": null,
"aa_length": 1136,
"cds_start": 3096,
"cds_end": null,
"cds_length": 3411,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_012292.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000313093.7"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3108G>C",
"hgvs_p": "p.Ser1036Ser",
"transcript": "ENST00000586866.5",
"protein_id": "ENSP00000468615.1",
"transcript_support_level": 1,
"aa_start": 1036,
"aa_end": null,
"aa_length": 1140,
"cds_start": 3108,
"cds_end": null,
"cds_length": 3423,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000586866.5"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3180G>C",
"hgvs_p": "p.Ser1060Ser",
"transcript": "ENST00000885660.1",
"protein_id": "ENSP00000555719.1",
"transcript_support_level": null,
"aa_start": 1060,
"aa_end": null,
"aa_length": 1164,
"cds_start": 3180,
"cds_end": null,
"cds_length": 3495,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885660.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3177G>C",
"hgvs_p": "p.Ser1059Ser",
"transcript": "ENST00000590214.5",
"protein_id": "ENSP00000466401.1",
"transcript_support_level": 5,
"aa_start": 1059,
"aa_end": null,
"aa_length": 1163,
"cds_start": 3177,
"cds_end": null,
"cds_length": 3492,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000590214.5"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3165G>C",
"hgvs_p": "p.Ser1055Ser",
"transcript": "ENST00000964187.1",
"protein_id": "ENSP00000634246.1",
"transcript_support_level": null,
"aa_start": 1055,
"aa_end": null,
"aa_length": 1159,
"cds_start": 3165,
"cds_end": null,
"cds_length": 3480,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000964187.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3144G>C",
"hgvs_p": "p.Ser1048Ser",
"transcript": "NM_001258328.4",
"protein_id": "NP_001245257.1",
"transcript_support_level": null,
"aa_start": 1048,
"aa_end": null,
"aa_length": 1152,
"cds_start": 3144,
"cds_end": null,
"cds_length": 3459,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001258328.4"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3144G>C",
"hgvs_p": "p.Ser1048Ser",
"transcript": "ENST00000539243.6",
"protein_id": "ENSP00000439601.1",
"transcript_support_level": 2,
"aa_start": 1048,
"aa_end": null,
"aa_length": 1152,
"cds_start": 3144,
"cds_end": null,
"cds_length": 3459,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000539243.6"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3108G>C",
"hgvs_p": "p.Ser1036Ser",
"transcript": "NM_001321232.2",
"protein_id": "NP_001308161.1",
"transcript_support_level": null,
"aa_start": 1036,
"aa_end": null,
"aa_length": 1140,
"cds_start": 3108,
"cds_end": null,
"cds_length": 3423,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001321232.2"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3099G>C",
"hgvs_p": "p.Ser1033Ser",
"transcript": "ENST00000885658.1",
"protein_id": "ENSP00000555717.1",
"transcript_support_level": null,
"aa_start": 1033,
"aa_end": null,
"aa_length": 1137,
"cds_start": 3099,
"cds_end": null,
"cds_length": 3414,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885658.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3081G>C",
"hgvs_p": "p.Ser1027Ser",
"transcript": "ENST00000885662.1",
"protein_id": "ENSP00000555721.1",
"transcript_support_level": null,
"aa_start": 1027,
"aa_end": null,
"aa_length": 1131,
"cds_start": 3081,
"cds_end": null,
"cds_length": 3396,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885662.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3051G>C",
"hgvs_p": "p.Ser1017Ser",
"transcript": "ENST00000885661.1",
"protein_id": "ENSP00000555720.1",
"transcript_support_level": null,
"aa_start": 1017,
"aa_end": null,
"aa_length": 1121,
"cds_start": 3051,
"cds_end": null,
"cds_length": 3366,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885661.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3012G>C",
"hgvs_p": "p.Ser1004Ser",
"transcript": "ENST00000885659.1",
"protein_id": "ENSP00000555718.1",
"transcript_support_level": null,
"aa_start": 1004,
"aa_end": null,
"aa_length": 1108,
"cds_start": 3012,
"cds_end": null,
"cds_length": 3327,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885659.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.2745G>C",
"hgvs_p": "p.Ser915Ser",
"transcript": "NM_001282335.3",
"protein_id": "NP_001269264.1",
"transcript_support_level": null,
"aa_start": 915,
"aa_end": null,
"aa_length": 1019,
"cds_start": 2745,
"cds_end": null,
"cds_length": 3060,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001282335.3"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.2745G>C",
"hgvs_p": "p.Ser915Ser",
"transcript": "ENST00000543365.5",
"protein_id": "ENSP00000438979.1",
"transcript_support_level": 2,
"aa_start": 915,
"aa_end": null,
"aa_length": 1019,
"cds_start": 2745,
"cds_end": null,
"cds_length": 3060,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000543365.5"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.2001G>C",
"hgvs_p": "p.Ser667Ser",
"transcript": "NM_001282334.2",
"protein_id": "NP_001269263.1",
"transcript_support_level": null,
"aa_start": 667,
"aa_end": null,
"aa_length": 771,
"cds_start": 2001,
"cds_end": null,
"cds_length": 2316,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001282334.2"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.2001G>C",
"hgvs_p": "p.Ser667Ser",
"transcript": "ENST00000590577.2",
"protein_id": "ENSP00000468607.1",
"transcript_support_level": 2,
"aa_start": 667,
"aa_end": null,
"aa_length": 771,
"cds_start": 2001,
"cds_end": null,
"cds_length": 2316,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000590577.2"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3228G>C",
"hgvs_p": "p.Ser1076Ser",
"transcript": "XM_047438545.1",
"protein_id": "XP_047294501.1",
"transcript_support_level": null,
"aa_start": 1076,
"aa_end": null,
"aa_length": 1180,
"cds_start": 3228,
"cds_end": null,
"cds_length": 3543,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047438545.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3192G>C",
"hgvs_p": "p.Ser1064Ser",
"transcript": "XM_011527858.1",
"protein_id": "XP_011526160.1",
"transcript_support_level": null,
"aa_start": 1064,
"aa_end": null,
"aa_length": 1168,
"cds_start": 3192,
"cds_end": null,
"cds_length": 3507,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011527858.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3180G>C",
"hgvs_p": "p.Ser1060Ser",
"transcript": "XM_047438546.1",
"protein_id": "XP_047294502.1",
"transcript_support_level": null,
"aa_start": 1060,
"aa_end": null,
"aa_length": 1164,
"cds_start": 3180,
"cds_end": null,
"cds_length": 3495,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047438546.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3108G>C",
"hgvs_p": "p.Ser1036Ser",
"transcript": "XM_047438547.1",
"protein_id": "XP_047294503.1",
"transcript_support_level": null,
"aa_start": 1036,
"aa_end": null,
"aa_length": 1140,
"cds_start": 3108,
"cds_end": null,
"cds_length": 3423,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047438547.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP45",
"gene_hgnc_id": 17102,
"hgvs_c": "c.3096G>C",
"hgvs_p": "p.Ser1032Ser",
"transcript": "XM_047438548.1",
"protein_id": "XP_047294504.1",
"transcript_support_level": null,
"aa_start": 1032,
"aa_end": null,
"aa_length": 1136,
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{
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}
],
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}